Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101711 - 101711
Published: March 27, 2025
Developing
and
utilizing
effective
local
antimicrobial
agents
can
help
treat
periodontitis
while
minimizing
the
risks
associated
with
systemic
antibiotic
use.
Recent
studies
have
shown
that
mucosal
adhesion
properties
of
hydrogels
play
a
potential
role
in
treatment
periodontitis.
The
hydrogel
improve
contact
retention
time
drugs
periodontal
pocket.
Through
mucosa,
it
interacts
mucin
coating
surface
epithelium
teeth
to
form
specific
interface
force.
exhibits
strong
(adhesion
strength:
5-6
N/cm2)
prolonged
pockets
(≥6
h),
enabling
sustained
drug
release
through
dynamic
sol-gel
transitions
triggered
by
pH
reactive
oxygen
species
(ROS).
This
design
overcomes
limitations
poor
mechanical
stability
conventional
formulations.
balance
oral
microbiota
plays
an
important
maintaining
health.
Probiotics,
colonizing
cavity,
transform
infected
site
from
environment
rich
inflammatory
cytokines
more
benign
environment,
inhibit
harmful
pathogenic
microorganisms,
contribute
overall
Microenvironment
sensitive
perform
sol
gel
transformation
situ,
accurately
control
when
exposed
various
stimuli
(such
as
temperature
change,
light,
species,
etc.).
Oral
probiotics
anti-inflammatory
are
encapsulated
proliferation
pathogens
planting
mouth
producing
metabolites,
effectively
preventing
treating
diseases.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: May 6, 2024
Abstract
Diabetic
foot
ulcers
(DFUs),
a
serious
and
increasingly
common
chronic
issue
among
diabetics,
often
do
not
respond
well
to
generalized
treatment
strategies.
Hypoxia
the
overexpression
of
reactive
oxygen
species
(ROS),
resulting
in
inflammatory
dysregulation
subsequent
imbalance
macrophage
phenotypes,
are
critical
factors
contributing
prolonged
non‐healing
DFU
wounds.
These
two
issues
interact
continuous,
problematic
cycle.
Presently,
there
is
lack
comprehensive
strategies
aimed
at
addressing
both
these
simultaneously
interrupt
this
detrimental
Herein,
an
immunomodulatory
hydrogel
(PHG2)
developed
for
reshaping
hostile
microenvironment.
The
engineered
PHG2
only
removes
excess
internally‐produced
ROS
but
also
generates
O
2
,
with
its
efficiency
further
boosted
by
local
hyperthermia
(42.5
°C)
activated
near‐infrared
light.
Through
vitro
vivo
studies,
along
transcriptomic
assessment,
it
confirmed
that
disrupts
feedback
loop
between
inflammation
while
lowering
M1/M2
ratio.
Such
discoveries
contribute
significant
enhancement
healing
process
injuries
undergo
gradual
increase
movement,
covering
wounds
from
back,
mouth,
foot.
Ultimately,
method
provides
easy,
safe,
highly
effective
solution
treating
DFUs.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 123 - 123
Published: Feb. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(2), P. 648 - 655
Published: Jan. 22, 2024
The
development
of
transparent
wearable
devices
capable
self-healing
and
efficient
fog
removal
is
great
significance.
In
this
study,
we
have
realized
the
fabrication
a
composite
film
exhibiting
remarkable
transparency
along
with
light-triggered
healing
defogging
capabilities.
This
was
achieved
by
integrating
plasmonic
silver
nanoparticle
(AgNPs)
embedded
covalent–organic
framework
(COF)
nanosheets,
denoted
as
AgNPs/CONs,
into
waterborne
elastic
polyurethane
(PU)
matrix.
Due
to
synergistic
effect
between
AgNPs
high
properties
COF
nanosheets
excellent
photothermal
characteristics,
resulting
film,
even
an
ultralow
loading
AgNPs/CONs
(0.15
wt
%),
demonstrate
rapid
temperature
increase
80
°C
upon
exposure
500
mW
cm–2
near-infrared
(NIR)
light
irradiation
for
12
s.
Simultaneously,
it
maintains
optical
transmittance
96.2%
at
thin
thickness
20
μm
extremely
low
(0.08
%).
localized
elevation
effectively
eliminates
surface
promotes
mechanical
damage
within
achieving
efficiency
exceeding
98%.
Our
findings
represent
significant
advancement
in
design
photothermally
active
materials
based
on
COFs,
opening
up
new
prospects
next-generation
electronic
applications.
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 241 - 241
Published: April 1, 2024
This
manuscript
explores
self-healing
hydrogels
as
innovative
solutions
for
diverse
wound
management
challenges.
Addressing
antibiotic
resistance
and
tailored
care,
these
exhibit
promising
outcomes,
including
accelerated
closure
tissue
regeneration.
Advancements
in
multifunctional
with
controlled
drug
release,
antimicrobial
properties,
real-time
assessment
capabilities
signal
a
significant
leap
toward
patient-centered
treatments.
However,
challenges
such
scalability,
long-term
safety
evaluation,
variability
clinical
outcomes
persist.
Future
directions
emphasize
personalized
medicine,
manufacturing
innovation,
rigorous
evaluation
through
trials,
interdisciplinary
collaboration.
features
the
ongoing
pursuit
of
effective,
adaptable,
comprehensive
care
to
transform
medical
treatments
improve
patient
outcomes.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(16), P. 3721 - 3746
Published: Jan. 1, 2024
Hydrogels
with
intricate
3D
networks
and
high
hydrophilicity
have
qualities
resembling
those
of
biological
tissues,
making
them
ideal
candidates
for
use
as
smart
biomedical
materials.
Reactive
oxygen
species
(ROS)
responsive
hydrogels
are
an
innovative
class
hydrogels,
cross-linked
by
ROS-responsive
modules
through
covalent
interactions,
coordination
or
supramolecular
interactions.
Due
to
the
introduction
ROS
response
modules,
this
exhibits
a
sensitive
oxidative
stress
microenvironment
existing
in
organisms.
Simultaneously,
due
modularity
structure,
can
be
manufactured
on
large
scale
additive
manufacturing.
This
review
will
delve
into
design,
fabrication,
applications
hydrogels.
The
main
goal
is
clarify
chemical
principles
that
govern
mechanism
these
further
providing
new
perspectives
methods
designing
hydrogel
