Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

---

Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Ноя. 8, 2023

Ferroptosis-triggered immunogenic cell death (ICD) is widely adopted to potentiate the body's antitumor immunity by catalyzing production of toxic reactive oxygen species (ROS). However, efficacy ferroptosis and immunotherapy greatly restricted intracellular abundant glutathione (GSH) immunosuppressive tumor microenvironment (TME). Herein, a facile bottom-up method for solvent-free synthesis ultrathin manganese (Mn)-based layered double hydroxide nanosheets with high loading efficiency pro-inflammatory cytokine interferon (IFNγ) (IFNγ/uMn-LDHs) proposed mutually reinforce systemic immunity. The introduction ions significantly contributes GSH depletion hydroxyl radical generation, which can be further enhanced IFNγ delivery-induced SLC7A11 downregulation. ICD effect after cooperates intrinsic immunomodulatory property IFNγ/uMn-LDHs facilitate maturation dendritic cells (DCs) priming T cells. secretion from activated CD8

Язык: Английский

---

“Multi‐in‐One” Yolk‐Shell Structured Nanoplatform Inducing Pyroptosis and Antitumor Immune Response Through Cascade Reactions

Small, Год журнала: 2024, Номер 20(30)

Опубликована: Фев. 25, 2024

Abstract Pyroptosis, a new mode of regulatory cell death, holds promising prospect in tumor therapy. The occurrence pyroptosis can trigger the release damage‐associated molecular patterns (DAMPs) and activate antitumor immune response. Moreover, enhancing intracellular reactive oxygen species (ROS) generation effectively induce pyroptosis. Herein, an integrated nanoplatform (hCZAG) based on zeolitic imidazolate framework‐8 (ZIF‐8) with Cu 2+ Zn as active nodes glucose oxidase (GOx) loading is constructed to evoke GOx elevate hydrogen peroxide (H 2 O ) levels regulate unfavorable microenvironment (TME). be reduced + by endogenous overexpressed GSH both exert Fenton‐like activity promote ROS amplify oxidative stress. In addition, accumulation leads aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), thus resulting cuproptosis. Notably, outburst induced hCZAG activates Caspase‐1 proteins, cleavage gasdermin D (GSDMD), induces Pyroptosis further elicits adaptive response, leading immunogenic death (ICD). This study provides effective strategies for triggering pyroptosis‐mediated immunotherapy achieving improved therapeutic effects.

Язык: Английский

---

Zinc Coordination Lipid Nanoparticles Co‐Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy

Small, Год журнала: 2024, Номер 20(46)

Опубликована: Авг. 8, 2024

Abstract Metalloimmunotherapy has achieved great preclinical success against malignant tumors. Nonetheless, the limited immune cell infiltration and impaired immunogenicity within tumor microenvironment (TME) significantly hinder its translation to clinical applications. In this study, a zinc coordination lipid nanoparticle is developed loaded with calcium peroxide hydrate (CaO 2 ) nanoparticles STING agonist diABZI‐2, which termed A‐CaO ‐Zn‐LNP. The release of Zn 2+ from ‐Zn‐LNP overload synergistically induced immunogenic death (ICD). addition, CaO can consume H + oxygen (O under acidic conditions. This treatment increased pH alleviated hypoxia TME. Along cGAS‐STING activation by ultimately results in enhanced anti‐tumor systemic immunity long‐term memory via alleviating immunosuppressive microenvironment. Taken together, offers new nanoplatform that expands application for cancer metalloimmunotheray.

Язык: Английский

---

A multifunctional fluorescent probe for tracking SO2 fluctuation between mitochondria and endoplasmic reticulum in living cells and zebrafish

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 412, С. 135795 - 135795

Опубликована: Апрель 9, 2024

Язык: Английский

---

Harnessing phytochemicals: innovative strategies to enhance cancer immunotherapy

Drug Resistance Updates, Год журнала: 2025, Номер 79, С. 101206 - 101206

Опубликована: Фев. 1, 2025

Cancer immunotherapy has revolutionized cancer treatment, but therapeutic ineffectiveness-driven by the tumor microenvironment and immune evasion mechanisms-continues to limit its clinical efficacy. This challenge underscores need explore innovative approaches, such as multimodal immunotherapy. Phytochemicals, bioactive compounds derived from plants, have emerged promising candidates for overcoming these barriers due their immunomodulatory antitumor properties. review explores synergistic potential of phytochemicals in enhancing modulating responses, reprogramming microenvironment, reducing immunosuppressive factors. Integrating with conventional strategies represents a novel approach mitigating resistance outcomes. For instance, nab-paclitaxel shown checkpoint inhibitors, while QS-21 synergistically enhances efficacy vaccines. Furthermore, we highlight recent advancements leveraging nanotechnology engineer improved bioavailability targeted delivery. These innovations hold great promise optimizing application phytochemicals. However, further large-scale studies are crucial fully integrate into immunotherapeutic regimens effectively.

Язык: Английский

---

CaCO₃ nanoplatform for cancer treatment: drug delivery and combination therapy

Nanoscale, Год журнала: 2024, Номер 16(14), С. 6876 - 6899

Опубликована: Янв. 1, 2024

CaCO 3 nanoparticles as nanocarriers for drug, protein, gene, and co-delivery are discussed. Furthermore, their combinations with other therapies, including photodynamic therapy, sonodynamic immunotherapy, imaging, reviewed.

Язык: Английский

---

Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(36)

Опубликована: Март 4, 2024

Abstract Immunogenic cell death (ICD) is a promising strategy for anticancer immunity by inducing antigen‐presenting maturation. However, the traditional ICD inducers, such as chemotherapeutic agents, have largely hampered their application severe side effects and low tumor selectivity. The changes intra/extracellular ion concentrations affect growth metastasis of cells. Interference with homeostasis can induce elicit immune responses. Here, biomimetic Ga‐based metal–organic framework (MOF) coated red blood cell–platelet fusion membrane (RPM), that is, 5‐fluorouracil@GaMOF@RPM (5‐FUGR) nano‐immunoactivator, reported highly efficient inducer enhanced microwave (MW)‐immunotherapy. Following intravenous administration, 5‐FUGR accumulates to site via RPM modification‐mediated long circulation active targeting. structure undergoes degradation releases Ga 3+ . MW combined high disrupts intracellular homeostasis, which leads oxidative stress Ca 2+ retention promote apoptosis More importantly, not only completely eradicates 4T1 primary tumors, but also induces ICD, initiation, memory inhibit metastatic recurrence tumor. Thus, 5‐FUGR, strong inducer, provides new insights into achieving in combination other therapies.

Язык: Английский

---

Inorganic Nanoparticle Functionalization Strategies in Immunotherapeutic Applications

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Язык: Английский

---

Nano-modulators with the function of disrupting mitochondrial Ca2+ homeostasis and photothermal conversion for synergistic breast cancer therapy

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 4, 2023

Breast cancer treatment has been a global puzzle, and apoptosis strategies based on mitochondrial Ca2+ overload have attracted extensive attention. However, various limitations of current nanogenerators make it difficult to maintain effective concentrations. Here, we constructed multimodal nano-modulator that, for the first time, combined photothermal therapy (PTT) inhibit tumor development. By crosslinking sodium alginate (SA) surface calcium carbonate (CaCO3) nanoparticles encapsulating with Cur ICG, prepared synergistic nano-regulator SA/Cur@CaCO3-ICG (SCCI). In vitro studies shown that SCCI further enhanced photostability while preserving optical properties ICG. After uptake by cells, can reduce membrane potential down-regulate ATP production producing large amounts at low pH. Near-infrared light radiation (NIR) laser irradiation made cells heat up sharply, which not only accelerated decomposition CaCO3, but also produced reactive oxygen species (ROS) followed cell apoptosis. vivo revealed nano-regulators had excellent targeting, biocompatibility, anti-tumor effects, significantly proliferation play direct killing effect. These findings indicated therapeutic ionic interference PTT great potential, providing new insights into antitumor therapy.

Язык: Английский

---