Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Язык: Английский

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Metformin-Mediated Fast Charge-Reversal Nanohybrid for Deep Penetration Piezocatalysis-Augmented Chemodynamic Immunotherapy of Cancer

ACS Nano, Год журнала: 2024, Номер 18(8), С. 6314 - 6332

Опубликована: Фев. 12, 2024

Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)- ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy cancer. Interestingly, had negative charge blood circulation, which rapidly changed into positive when exposed acidic TME attributed quaternization tertiary amine Met, facilitating deep penetration. Subsequently, US irradiation, produced H2O2 based piezocatalysis BaTiO3, greatly enhanced Fenton reaction Fe3O4, thus boosting robust antitumor response. Furthermore, PD-L1 expression inhibited by local released Met further augment effect, achieving inhibitions primary metastatic tumors. Such combination piezocatalysis-enhanced chemodynamic Met-mediated downregulation provides promising strategy cancer immunotherapy.

Язык: Английский

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Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection

Biomaterials, Год журнала: 2024, Номер 307, С. 122532 - 122532

Опубликована: Март 14, 2024

Язык: Английский

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Oxygen‐Vacancy‐Engineered W₁₈O_49−x Nanobrush with a Suitable Band Structure for Highly Efficient Sonodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 12, 2024

With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W

Язык: Английский

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Interconversion of sp-hybridized chemical bonds induces piezoelectric enhanced photocatalysis

Applied Catalysis B Environment and Energy, Год журнала: 2024, Номер 349, С. 123868 - 123868

Опубликована: Апрель 24, 2024

Язык: Английский

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