Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 819 - 846

Опубликована: Авг. 23, 2023

Язык: Английский

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Enzyme/pH Dual-Responsive Engineered Nanoparticles for Improved Tumor Immuno-Chemotherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(10), С. 12951 - 12964

Опубликована: Фев. 29, 2024

Combining immune checkpoint blockade (ICB) therapy with chemotherapy can enhance the efficacy of ICB and expand its indications. However, limited tumor specificity drugs results in severe adverse reactions. Additionally, low tissue penetration immune-related events associated monoclonal antibodies restrict their widespread application. To address challenges faced by traditional combination therapies, we design a dual-responsive engineered nanoparticle based on ferritin (denoted as CMFn@OXA), achieving tumor-targeted delivery controlled release anti-PD-L1 peptide CLP002 oxaliplatin (OXA). Our demonstrate that CMFn@OXA not only exhibits tumor-specific accumulation but also responds to matrix metalloproteinase-2/9 (MMP-2/9), facilitating block PD-1/PD-L1 interaction. Simultaneously, it ensures precise OXA cells subsequent within acidic environment lysosomes, thereby fostering synergistic therapeutic effect. Compared demonstrates superior performance inhibiting growth, extending survival tumor-bearing mice, exhibiting excellent biocompatibility. Collectively, our highlight novel promising strategy field cancer immunotherapy.

Язык: Английский

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Nanodrug Delivery Systems in Antitumor Immunotherapy

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cancer has become one of the most important factors threatening human health, and global cancer burden been increasing rapidly. Immunotherapy another clinical research hotspot after surgery, chemotherapy, radiotherapy because its high efficiency tumor metastasis prevention. However, problems such as lower immune response rate immune-related adverse reaction in application immunotherapy need to be urgently solved. With development nanodrug delivery systems, various nanocarrier materials have used antitumor with encouraging therapeutic results. In this review, we mainly summarized combination systems from following 4 aspects: (a) combined cytokine therapy improve cytokines vivo; (b) provided a suitable platform for checkpoint blockade other treatments; (c) helped deliver antigens adjuvants vaccines enhance effects; (d) improved treatment reduced toxicity adoptive cell therapy. Nanomaterials chosen by researchers construct their function were also introduced detail. Finally, discussed current challenges future prospects combining immunotherapy.

Язык: Английский

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Elucidation of Spatial Cooperativity in Chemo‐Immunotherapy by a Sequential Dual‐pH‐Responsive Drug Delivery System

Advanced Materials, Год журнала: 2024, Номер 36(26)

Опубликована: Апрель 11, 2024

Combining immune checkpoint blockade with chemotherapy through nanotechnology is promising in terms of safety and efficacy. However, the distinct subcellular distribution each ingredient's action site makes it challenging to acquire an optimal synergism. Herein, a dual-pH responsive hybrid polymeric micelle system, HNP(αPDL1

Язык: Английский

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Designing Peptide-Based Nanoinhibitors of Programmed Cell Death Ligand 1 (PD-L1) for Enhanced Chemo-immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(2), С. 1690 - 1701

Опубликована: Янв. 2, 2024

The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment various cancers. However, circulating regeneration PD-L1 within tumor cells greatly limits efficiency chemo-immunotherapy consequent patient response rates. Herein, we report synthesis a nanoparticle-based inhibitor (FRS) with rational design for effective endogenous suppression. nanoinhibitor is achieved through self-assembly fluoroalkylated competitive peptides that target palmitoylation. FRS nanoparticles provide efficient protection delivery functional to cytoplasm tumors, showing greater inhibition than nonfluorinated peptidic inhibitors. Moreover, demonstrate synergizes chemotherapeutic doxorubicin (DOX) boost antitumor activities via simultaneous reduction abundance induction immunogenic cell death murine colon models. nano strategy regulation present this study expected advance development ICB inhibitors overcome limitations conventional ICB-assisted chemo-immunotherapy.

Язык: Английский

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Charge-reversal biodegradable nanoplatform with ferroptosis and ICD induction for tumor synergistic treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 483, С. 149234 - 149234

Опубликована: Янв. 30, 2024

Язык: Английский

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Platinum-based combination nanomedicines for cancer therapy

Current Opinion in Chemical Biology, Год журнала: 2023, Номер 74, С. 102290 - 102290

Опубликована: Март 28, 2023

Язык: Английский

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Nanoassembly of doxorubicin-conjugated polyphosphoester and siRNA simultaneously elicited macrophage- and T cell- mediated anticancer immune response for cancer therapy

Biomaterials, Год журнала: 2023, Номер 302, С. 122339 - 122339

Опубликована: Сен. 25, 2023

Язык: Английский

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Disulfide Bond-Based SN38 Prodrug Nanoassemblies with High Drug Loading and Reduction-Triggered Drug Release for Pancreatic Cancer Therapy

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 1281 - 1298

Опубликована: Март 1, 2023

Chemotherapy is a significant and effective therapeutic strategy that frequently utilized in the treatment of cancer. Small molecular prodrug-based nanoassemblies (SMPDNAs) combine benefits both prodrugs nanomedicine into single nanoassembly with high drug loading, increased stability, improved biocompatibility.In this study, disulfide bond inserted 7-ethyl-10-hydroxycamptothecin (SN38) prodrug was rationally designed then used to prepare (SNSS NAs) were selectively activated by rich glutathione (GSH) tumor site. The characterization SNSS NAs vitro vivo evaluation their antitumor effect on pancreatic cancer model performed.In findings demonstrated exhibited GSH-induced SN38 release cytotoxicity. have passive targeting tissues, superior compared irinotecan (CPT-11), satisfactory biocompatibility double dosage treatment.The developed study provide new method for preparation SN38-based nano-delivery systems biosafety.

Язык: Английский

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Calcium-Mediated Cell Adhesion Enhancement-Based Antimetastasis and Synergistic Antitumor Therapy by Conjugated Polymer–Calcium Composite Nanoparticles

ACS Nano, Год журнала: 2024, Номер 18(36), С. 24953 - 24967

Опубликована: Авг. 28, 2024

Strengthening tumor cellular adhesion through regulating the concentration of extracellular Ca2+ is highly challenging and promising for antimetastasis. Herein, a pH-responsive conjugated polymer–calcium composite nanoparticle (PFV/CaCO3/PDA@PEG) developed calcium-mediated cell enhancement-based antimetastasis reactive oxygen species (ROS)-triggered calcium overload photodynamic therapy (PDT) synergistic treatment. PFV/CaCO3/PDA@PEG mainly equipped with poly(fluorene-co-vinylene) (PFV-COOH)-composited CaCO3 nanoparticles, which can be rapidly decomposed under acidic microenvironment, effectively releasing photosensitizer PFV-COOH. The high facilitates generation dimers between two adjacent cadherin ectodomains, greatly enhances cell–cell suppresses metastasis. inhibition rates are 97 87% metastatic cells 4T1 MCF-7, respectively. Such well-designed also contributes to realizing PDT, mitochondrial dysfunction, ROS-triggered therapy. Furthermore, displayed superior in vivo growth demonstrated marked antimetastatic effect by both intravenous intratumoral injection modes. Thus, this study provides powerful strategy metastasis

Язык: Английский

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