Theranostics,
Journal Year:
2025,
Volume and Issue:
15(9), P. 4147 - 4174
Published: March 15, 2025
Magnetic
resonance
imaging
(MRI)
guidance
in
the
realm
of
anticancer
therapy
is
crucial
to
visualize
spread
tumors
deep
tissues,
accumulate
therapeutics,
and
trigger
them
for
precise
therapy.
Recent
studies
bridge
this
gap
by
integrating
MRI
contrast
agents
(CAs)
with
different
therapeutic
regimes
a
better
outcome.
In
context,
manganese-based
materials
hold
great
potential
owing
their
T1/T2
dual-modal
MR-relaxation,
less
toxicity,
other
capabilities
such
as
chemodynamic
therapy,
immunotherapy,
etc.,
which
have
gained
increasing
interest
among
researchers
medical
professionals.
This
work
offers
timely
update
on
last
three
years
Mn-based
MRI-guided
theranostic
applications,
including
chemotherapy,
photo
therapies,
sonodynamic
radiotherapy
against
cancer.
Further,
several
combinatory
therapies
surgical
intersections
also
been
summarized
light
guidance.
The
design
rationale
these
has
discussed
understand
existing
challenges
plausible
outcomes
shortly.
Herein,
we
dive
into
stimulus-based
probes
pH,
temperature,
etc.
show
unexplored
Mn-complexes
domain.
state-of-the-art
review
will
guide
innovations
CAs
expedite
safer
modules
clinical
translation.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: April 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(9)
Published: Nov. 8, 2023
Ferroptosis-triggered
immunogenic
cell
death
(ICD)
is
widely
adopted
to
potentiate
the
body's
antitumor
immunity
by
catalyzing
production
of
toxic
reactive
oxygen
species
(ROS).
However,
efficacy
ferroptosis
and
immunotherapy
greatly
restricted
intracellular
abundant
glutathione
(GSH)
immunosuppressive
tumor
microenvironment
(TME).
Herein,
a
facile
bottom-up
method
for
solvent-free
synthesis
ultrathin
manganese
(Mn)-based
layered
double
hydroxide
nanosheets
with
high
loading
efficiency
pro-inflammatory
cytokine
interferon
(IFNγ)
(IFNγ/uMn-LDHs)
proposed
mutually
reinforce
systemic
immunity.
The
introduction
ions
significantly
contributes
GSH
depletion
hydroxyl
radical
generation,
which
can
be
further
enhanced
IFNγ
delivery-induced
SLC7A11
downregulation.
ICD
effect
after
cooperates
intrinsic
immunomodulatory
property
IFNγ/uMn-LDHs
facilitate
maturation
dendritic
cells
(DCs)
priming
T
cells.
secretion
from
activated
CD8
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: Feb. 25, 2024
Abstract
Pyroptosis,
a
new
mode
of
regulatory
cell
death,
holds
promising
prospect
in
tumor
therapy.
The
occurrence
pyroptosis
can
trigger
the
release
damage‐associated
molecular
patterns
(DAMPs)
and
activate
antitumor
immune
response.
Moreover,
enhancing
intracellular
reactive
oxygen
species
(ROS)
generation
effectively
induce
pyroptosis.
Herein,
an
integrated
nanoplatform
(hCZAG)
based
on
zeolitic
imidazolate
framework‐8
(ZIF‐8)
with
Cu
2+
Zn
as
active
nodes
glucose
oxidase
(GOx)
loading
is
constructed
to
evoke
GOx
elevate
hydrogen
peroxide
(H
2
O
)
levels
regulate
unfavorable
microenvironment
(TME).
be
reduced
+
by
endogenous
overexpressed
GSH
both
exert
Fenton‐like
activity
promote
ROS
amplify
oxidative
stress.
In
addition,
accumulation
leads
aggregation
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
thus
resulting
cuproptosis.
Notably,
outburst
induced
hCZAG
activates
Caspase‐1
proteins,
cleavage
gasdermin
D
(GSDMD),
induces
Pyroptosis
further
elicits
adaptive
response,
leading
immunogenic
death
(ICD).
This
study
provides
effective
strategies
for
triggering
pyroptosis‐mediated
immunotherapy
achieving
improved
therapeutic
effects.
Small,
Journal Year:
2024,
Volume and Issue:
20(46)
Published: Aug. 8, 2024
Abstract
Metalloimmunotherapy
has
achieved
great
preclinical
success
against
malignant
tumors.
Nonetheless,
the
limited
immune
cell
infiltration
and
impaired
immunogenicity
within
tumor
microenvironment
(TME)
significantly
hinder
its
translation
to
clinical
applications.
In
this
study,
a
zinc
coordination
lipid
nanoparticle
is
developed
loaded
with
calcium
peroxide
hydrate
(CaO
2
)
nanoparticles
STING
agonist
diABZI‐2,
which
termed
A‐CaO
‐Zn‐LNP.
The
release
of
Zn
2+
from
‐Zn‐LNP
overload
synergistically
induced
immunogenic
death
(ICD).
addition,
CaO
can
consume
H
+
oxygen
(O
under
acidic
conditions.
This
treatment
increased
pH
alleviated
hypoxia
TME.
Along
cGAS‐STING
activation
by
ultimately
results
in
enhanced
anti‐tumor
systemic
immunity
long‐term
memory
via
alleviating
immunosuppressive
microenvironment.
Taken
together,
offers
new
nanoplatform
that
expands
application
for
cancer
metalloimmunotheray.
Drug Resistance Updates,
Journal Year:
2025,
Volume and Issue:
79, P. 101206 - 101206
Published: Feb. 1, 2025
Cancer
immunotherapy
has
revolutionized
cancer
treatment,
but
therapeutic
ineffectiveness-driven
by
the
tumor
microenvironment
and
immune
evasion
mechanisms-continues
to
limit
its
clinical
efficacy.
This
challenge
underscores
need
explore
innovative
approaches,
such
as
multimodal
immunotherapy.
Phytochemicals,
bioactive
compounds
derived
from
plants,
have
emerged
promising
candidates
for
overcoming
these
barriers
due
their
immunomodulatory
antitumor
properties.
review
explores
synergistic
potential
of
phytochemicals
in
enhancing
modulating
responses,
reprogramming
microenvironment,
reducing
immunosuppressive
factors.
Integrating
with
conventional
strategies
represents
a
novel
approach
mitigating
resistance
outcomes.
For
instance,
nab-paclitaxel
shown
checkpoint
inhibitors,
while
QS-21
synergistically
enhances
efficacy
vaccines.
Furthermore,
we
highlight
recent
advancements
leveraging
nanotechnology
engineer
improved
bioavailability
targeted
delivery.
These
innovations
hold
great
promise
optimizing
application
phytochemicals.
However,
further
large-scale
studies
are
crucial
fully
integrate
into
immunotherapeutic
regimens
effectively.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
ABSTRACT
The
insufficient
infiltration
and
functional
inhibition
of
CD8
+
T
cells
due
to
tumor
microenvironment
(TME)
are
considered
enormous
obstacles
anti‐tumor
immunotherapy.
Herein,
a
pH‐responsive
core‐shell
manganese
phosphate
nanomodulator
co‐loading
siPD‐L1
Mn
2+
into
nanoparticles
coated
with
hyaluronic
acid
was
prepared,
which
aimed
at
the
bidirectional
reprogramming
microenvironment:
(1)
“Brakes
off,”
restoring
function
by
knockdowning
PD‐L1
expression
cells;
(2)
“Step
on
accelerator,”
promoting
in
tumors
tissue
based
multidimensional
immune
effects
(immunogenic
cell
death
induced
enhancing
cGAS‐STING
pathway,
proliferation
maturation
relative
cells).
Additionally,
this
strategy
could
induce
macrophage
polarization
inhibit
regulatory
site.
This
work
provided
reprogram
TME
for
an
enhanced
comprehensive
effect
triple
negative
breast
cancer,
offers
robust
method
immunotherapy
future
clinical
applications.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(14), P. 6876 - 6899
Published: Jan. 1, 2024
CaCO
3
nanoparticles
as
nanocarriers
for
drug,
protein,
gene,
and
co-delivery
are
discussed.
Furthermore,
their
combinations
with
other
therapies,
including
photodynamic
therapy,
sonodynamic
immunotherapy,
imaging,
reviewed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: March 4, 2024
Abstract
Immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
anticancer
immunity
by
inducing
antigen‐presenting
maturation.
However,
the
traditional
ICD
inducers,
such
as
chemotherapeutic
agents,
have
largely
hampered
their
application
severe
side
effects
and
low
tumor
selectivity.
The
changes
intra/extracellular
ion
concentrations
affect
growth
metastasis
of
cells.
Interference
with
homeostasis
can
induce
elicit
immune
responses.
Here,
biomimetic
Ga‐based
metal–organic
framework
(MOF)
coated
red
blood
cell–platelet
fusion
membrane
(RPM),
that
is,
5‐fluorouracil@GaMOF@RPM
(5‐FUGR)
nano‐immunoactivator,
reported
highly
efficient
inducer
enhanced
microwave
(MW)‐immunotherapy.
Following
intravenous
administration,
5‐FUGR
accumulates
to
site
via
RPM
modification‐mediated
long
circulation
active
targeting.
structure
undergoes
degradation
releases
Ga
3+
.
MW
combined
high
disrupts
intracellular
homeostasis,
which
leads
oxidative
stress
Ca
2+
retention
promote
apoptosis
More
importantly,
not
only
completely
eradicates
4T1
primary
tumors,
but
also
induces
ICD,
initiation,
memory
inhibit
metastatic
recurrence
tumor.
Thus,
5‐FUGR,
strong
inducer,
provides
new
insights
into
achieving
in
combination
other
therapies.
