Recent development of micro-nano carriers for oral antineoplastic drug delivery DOI Creative Commons
Hongzheng Li, Xiang Chen,

Shangrui Rao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101445 - 101445

Published: Jan. 5, 2025

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.

Language: Английский

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment DOI Creative Commons
Yujing Huang, Xiaohan Guo, Yi Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

Citations

151

Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway DOI
Ding Wang, Qi Jiang,

Zhefan Dong

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115130 - 115130

Published: Oct. 31, 2023

Language: Английский

Citations

46

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives DOI Open Access
Sanja Petrović, Bogdan Biță, Marcela Elisabeta Barbinta-Patrascu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

Citations

25

Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery DOI
Yisi Tang,

Bao Liu,

Yuting Zhang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115304 - 115304

Published: April 9, 2024

Language: Английский

Citations

21

Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation DOI Creative Commons
Yaxian Zheng,

Shiqin Luo,

Min Xu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3876 - 3900

Published: June 22, 2024

Despite the promising prospects of nanoparticles in oral drug delivery, process administration involves a complex transportation pathway that includes cellular uptake, intracellular trafficking, and exocytosis by intestinal epithelial cells, which are necessary steps for to enter bloodstream exert therapeutic effects. Current researchers have identified several crucial factors regulate interaction between including surface properties such as ligand modification, charge, hydrophilicity/hydrophobicity, protein corona formation, well holistic like particle size, shape, rigidity. Understanding these is essential enhancing transepithelial transport efficiency designing effective delivery systems. Therefore, this review provides comprehensive overview influence nanoparticles, elucidating underlying principles governing their impact on transport. The also outlines chosen parameters be considered subsequent design

Language: Английский

Citations

20

Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes DOI
Dan Yang, Yu‐Qi Feng, Ying Yuan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(10), P. 7455 - 7472

Published: Feb. 28, 2024

The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy diminished the formation of protein coronas (PCs) when they interact with matrices. PCs are broadly implicated in affecting fate NPs vivo vitro, yet few studies have investigated formed during interactions mucosa, especially mucus. In study, we constructed transferrin modified (Tf-NPs) as model explored mechanisms effects that had subsequent impact transcellular transport Tf-NPs. mucus-secreting cells, Tf-NPs adsorbed more proteins from mucus layers, which masked, displaced, dampened active targeting Tf-NPs, thereby weakening endocytosis efficiencies. mucus-free intracellular trafficking, enhanced transcytosis related functions. Inspired soft artificial biomimetic membranes, used mucin an "active PC" to precoat (M@Tf-NPs), limited negative impacts "passive PCs" interface improved favorable routes endocytosis. M@Tf-NPs associated endoplasmic reticulum-Golgi functions, prompting exocytosis. summary, shielded against absorption also could be employed spear break through barrier. These findings offer theoretical foundation design platform enhance efficiency oral-administered nanomedicines.

Language: Английский

Citations

19

Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and Administration Routes DOI Creative Commons
Sonia Losada‐Barreiro,

Sumeyye Celik,

Zerrin Sezgin Bayındır

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 852 - 852

Published: June 25, 2024

The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design drug delivery systems. In particular, introduction systems is a potential approach enhance uptake therapeutic agents deliver them at right time in amount concentration required site, as well open new strategies for effective illness treatment. this review, we provide basic understanding with an emphasis on use cyclodextrin-, polymer- surfactant-based These are very attractive because they biocompatible biodegradable nanomaterials multifunctional components. We also details considerations variety medical applications by employing several routes administration.

Language: Английский

Citations

11

Impact of physicochemical properties on biological effects of lipid nanoparticles: Are they completely safe DOI
Ziyi Yuan, Ruyu Yan,

Zuyi Fu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172240 - 172240

Published: April 4, 2024

Language: Английский

Citations

10

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties DOI Creative Commons
Т. И. Шабатина,

Yana A. Gromova,

O. I. Vernaya

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 587 - 587

Published: May 5, 2024

The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness pharmaceutical preparations to be increased due several factors: (1) high specific surface area nanomaterials, and (2) concentration surface-active centers interacting with biological objects. In case drug nanoforms, even low concentrations a bioactive substance can have significant effect on living organisms. These effects allow pharmacists lower doses active components, consequently lowering toxic side nanoform preparations. It is known that many are currently development poorly soluble water, so they insufficient bioavailability. Converting them into nanoforms will increase their rate dissolution, saturation solubility nanocrystals also makes contribution efficiency. Some physical chemical methods contribute formation both pure nanoparticles ligand or polymer-covered which characterized by higher stability. This review describes most commonly used for preparation (nanoparticles) different substances, paying close attention modern supercritical cryogenic technologies advantages disadvantages described techniques; moreover, improvements physico-chemical biomedical properties obtained discussed.

Language: Английский

Citations

10

Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer DOI Creative Commons
Junyi Zhang, Kamran Ali, Jianwei Wang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6693 - 6715

Published: July 1, 2024

Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) and poses an enormous threat to human health. Current strategies for metastatic colorectal (mCRC) therapy primarily focus on chemotherapy, targeted therapy, immunotherapy, radiotherapy; however, their adverse reactions drug resistance limit clinical application. Advances in nanotechnology have rendered lipid nanoparticles (LNPs) promising nanomaterial-based delivery system CRC therapy. LNPs can adapt the biological characteristics by modifying formulation, enabling selective drugs tissues. They overcome limitations traditional therapies, such as poor water solubility, nonspecific biodistribution, limited bioavailability. Herein, we review composition targeting Subsequently, applications these treatment including delivery, thermal nucleic acid-based gene are summarized with examples provided. The last section provides glimpse into advantages, current limitations, prospects CRC.

Language: Английский

Citations

10