Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101445 - 101445
Published: Jan. 5, 2025
Chemotherapy
is
widely
recognized
as
a
highly
efficacious
modality
for
cancer
treatment,
involving
the
administration
of
chemotherapeutic
agents
to
target
and
eradicate
tumor
cells.
Currently,
oral
stands
prevailing
utilized
method
delivering
chemotherapy
drugs.
However,
majority
anti-tumor
medications
exhibit
limited
solubility
permeability,
poor
stability
in
harsh
gastrointestinal
environments,
thereby
impeding
their
therapeutic
efficacy
chemotherapy.
Therefore,
more
micro-nano
drug
delivery
carriers
have
been
developed
used
effectively
deliver
anti-cancer
drugs,
which
can
overcome
physiological
barriers,
facilitate
administration,
ultimately
improve
efficacy.
In
this
paper,
we
first
discuss
effects
various
biological
barriers
on
approach.
Then,
development
based
biomedical
components,
such
micelles,
dendrimers,
hydrogels,
liposomes,
inorganic
nanoparticles,
etc.
were
introduced.
Finally,
current
dilemma
potential
clinical
treatment
discussed.
The
primary
objective
review
introduce
methods
serve
point
reference
advancement
novel
carriers,
with
ultimate
goal
informing
future
applications.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3876 - 3900
Published: June 22, 2024
Despite
the
promising
prospects
of
nanoparticles
in
oral
drug
delivery,
process
administration
involves
a
complex
transportation
pathway
that
includes
cellular
uptake,
intracellular
trafficking,
and
exocytosis
by
intestinal
epithelial
cells,
which
are
necessary
steps
for
to
enter
bloodstream
exert
therapeutic
effects.
Current
researchers
have
identified
several
crucial
factors
regulate
interaction
between
including
surface
properties
such
as
ligand
modification,
charge,
hydrophilicity/hydrophobicity,
protein
corona
formation,
well
holistic
like
particle
size,
shape,
rigidity.
Understanding
these
is
essential
enhancing
transepithelial
transport
efficiency
designing
effective
delivery
systems.
Therefore,
this
review
provides
comprehensive
overview
influence
nanoparticles,
elucidating
underlying
principles
governing
their
impact
on
transport.
The
also
outlines
chosen
parameters
be
considered
subsequent
design
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(10), P. 7455 - 7472
Published: Feb. 28, 2024
The
epithelial
mucosa
is
a
key
biological
barrier
faced
by
gastrointestinal,
intraoral,
intranasal,
ocular,
and
vaginal
drug
delivery.
Ligand-modified
nanoparticles
demonstrate
excellent
ability
on
this
process,
but
their
efficacy
diminished
the
formation
of
protein
coronas
(PCs)
when
they
interact
with
matrices.
PCs
are
broadly
implicated
in
affecting
fate
NPs
vivo
vitro,
yet
few
studies
have
investigated
formed
during
interactions
mucosa,
especially
mucus.
In
study,
we
constructed
transferrin
modified
(Tf-NPs)
as
model
explored
mechanisms
effects
that
had
subsequent
impact
transcellular
transport
Tf-NPs.
mucus-secreting
cells,
Tf-NPs
adsorbed
more
proteins
from
mucus
layers,
which
masked,
displaced,
dampened
active
targeting
Tf-NPs,
thereby
weakening
endocytosis
efficiencies.
mucus-free
intracellular
trafficking,
enhanced
transcytosis
related
functions.
Inspired
soft
artificial
biomimetic
membranes,
used
mucin
an
"active
PC"
to
precoat
(M@Tf-NPs),
limited
negative
impacts
"passive
PCs"
interface
improved
favorable
routes
endocytosis.
M@Tf-NPs
associated
endoplasmic
reticulum-Golgi
functions,
prompting
exocytosis.
summary,
shielded
against
absorption
also
could
be
employed
spear
break
through
barrier.
These
findings
offer
theoretical
foundation
design
platform
enhance
efficiency
oral-administered
nanomedicines.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 852 - 852
Published: June 25, 2024
The
disadvantages
of
some
conventional
drugs,
including
their
low
bioavailability,
poor
targeting
efficiency,
and
important
side
effects,
have
led
to
the
rational
design
drug
delivery
systems.
In
particular,
introduction
systems
is
a
potential
approach
enhance
uptake
therapeutic
agents
deliver
them
at
right
time
in
amount
concentration
required
site,
as
well
open
new
strategies
for
effective
illness
treatment.
this
review,
we
provide
basic
understanding
with
an
emphasis
on
use
cyclodextrin-,
polymer-
surfactant-based
These
are
very
attractive
because
they
biocompatible
biodegradable
nanomaterials
multifunctional
components.
We
also
details
considerations
variety
medical
applications
by
employing
several
routes
administration.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 587 - 587
Published: May 5, 2024
The
use
of
medicinal
substances
in
nanosized
forms
(nanoforms,
nanoparticles)
allows
the
therapeutic
effectiveness
pharmaceutical
preparations
to
be
increased
due
several
factors:
(1)
high
specific
surface
area
nanomaterials,
and
(2)
concentration
surface-active
centers
interacting
with
biological
objects.
In
case
drug
nanoforms,
even
low
concentrations
a
bioactive
substance
can
have
significant
effect
on
living
organisms.
These
effects
allow
pharmacists
lower
doses
active
components,
consequently
lowering
toxic
side
nanoform
preparations.
It
is
known
that
many
are
currently
development
poorly
soluble
water,
so
they
insufficient
bioavailability.
Converting
them
into
nanoforms
will
increase
their
rate
dissolution,
saturation
solubility
nanocrystals
also
makes
contribution
efficiency.
Some
physical
chemical
methods
contribute
formation
both
pure
nanoparticles
ligand
or
polymer-covered
which
characterized
by
higher
stability.
This
review
describes
most
commonly
used
for
preparation
(nanoparticles)
different
substances,
paying
close
attention
modern
supercritical
cryogenic
technologies
advantages
disadvantages
described
techniques;
moreover,
improvements
physico-chemical
biomedical
properties
obtained
discussed.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 6693 - 6715
Published: July 1, 2024
Colorectal
cancer
(CRC)
is
a
common
type
of
gastrointestinal
tract
(GIT)
and
poses
an
enormous
threat
to
human
health.
Current
strategies
for
metastatic
colorectal
(mCRC)
therapy
primarily
focus
on
chemotherapy,
targeted
therapy,
immunotherapy,
radiotherapy;
however,
their
adverse
reactions
drug
resistance
limit
clinical
application.
Advances
in
nanotechnology
have
rendered
lipid
nanoparticles
(LNPs)
promising
nanomaterial-based
delivery
system
CRC
therapy.
LNPs
can
adapt
the
biological
characteristics
by
modifying
formulation,
enabling
selective
drugs
tissues.
They
overcome
limitations
traditional
therapies,
such
as
poor
water
solubility,
nonspecific
biodistribution,
limited
bioavailability.
Herein,
we
review
composition
targeting
Subsequently,
applications
these
treatment
including
delivery,
thermal
nucleic
acid-based
gene
are
summarized
with
examples
provided.
The
last
section
provides
glimpse
into
advantages,
current
limitations,
prospects
CRC.
