NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

Bioactive Materials, Год журнала: 2024, Номер 36, С. 1 - 13

Опубликована: Фев. 21, 2024

Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) abnormal ATP energy metabolism related oxidative phosphorylation pathway in mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate redox balance have shown their potential treatment inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies chelate Pt

Язык: Английский

---

Choline Phosphate-Grafted Nanozymes as Universal Extracellular Vesicle Probes for Bladder Cancer Detection

ACS Nano, Год журнала: 2024, Номер 18(25), С. 16113 - 16125

Опубликована: Июнь 10, 2024

Urinary extracellular vesicles (uEVs) are regarded as highly promising liquid-biopsy biomarkers for the early diagnosis and prognosis of bladder cancer (BC). However, detection uEVs remains technically challenging owing to their huge heterogeneity ultralow abundance in real samples. We herein present a choline phosphate-grafted platinum nanozyme (Pt@CP) that acts universal EV probe construction high-throughput high-sensitivity immunoassay, which allowed multiplex profiling uEV protein markers BC detection. With Pt@CP-based immunoassays, three (MUC-1, CCDC25, GLUT1) were identified BC, by cases (n = 48), cystitis patients 27), healthy donors 24) discriminated with high clinical sensitivity specificity (area under curve 98.3%). For 9) after surgery, immunoassay could report postoperative residual tumor cannot be observed cystoscopy, is clinically significant assessing recurrence. This work provides generally detection, facilitating discovery use EV-based biomarkers.

Язык: Английский

---

Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)

Опубликована: Фев. 26, 2024

As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among diseases, fundus neovascularization diseases (FNDs) are prominent etiologies impairment worldwide. Intravitreal injection anti-vascular endothelial growth factor drugs remains primary therapy but is hurdled by common complications incomplete potency. To renovate current therapeutic modalities, nanomedicine emerged as times required, which endowed with advanced capabilities, able fulfill effective drug delivery achieve precise release control, thus further improving effect. This review provides a comprehensive summary advances in for FND management from state-of-the-art studies. First, modalities FNDs thoroughly introduced, focusing on key challenges delivery. Second, nanocarriers comprehensively reviewed posterior based nanostructures: polymer-based nanocarriers, lipid-based inorganic nanoparticles. Thirdly, characteristics microenvironment, their pathological changes during FNDs, corresponding strategies constructing smart elaborated. Furthermore, prospects discussed.

Язык: Английский

---

Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

---

Nanozymes for Treating Ocular Diseases

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 13, 2024

Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.

Язык: Английский

---

Nanotechnology for vision restoration

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 829 - 848

Опубликована: Июль 18, 2024

Язык: Английский

---

Axial Shortening Effects of Repeated Low-level Red-light Therapy in Children with High Myopia: A Multicenter Randomized Controlled Trial

American Journal of Ophthalmology, Год журнала: 2024, Номер 270, С. 203 - 215

Опубликована: Окт. 16, 2024

To evaluate the effectiveness and safety of repeated low-level red-light (RLRL) in delaying progression high myopes with -6.00 diopters (D) or worse. Multicenter, randomized, parallel-group, single-blind clinical trial. A total 202 myopic children aged 7 to 12 years cycloplegia spherical equivalent (SE) refraction ≤-6.00 D, astigmatism less than 2.50 anisometropia 1.50 D were enrolled from March 2022 December 2022. Follow-up was completed 2023. Eligible participants randomly allocated intervention (RLRL + single vision spectacle) control group (single spectacle). The RLRL treatment administered every day for 3 minutes, twice a day, an interval at least 4 hours. primary outcome change axial length (AL) months compared baseline. Secondary outcomes included changes SE, choroidal thickness (ChT), retinal (RT) different circle sectors. Outcomes analyzed by means intention-to-treat per-protocol methods. After treatment, AL SE -0.11 ± 0.25 mm 0.18 0.63 0.32 0.09 -0.80 0.42 group, respectively. Axial shortening >0.05 59% 0% months. ChT RT center analyzed. In thickened all sectors increased parafoveal perifoveal circles. only significantly thinner multivariate linear regression model revealed significant correlations between central foveal 1 month No fundus structure changes, afterimage exceeding 6 best-corrected visual acuity decrease reported. could effectively shorten inhibit myopia patients is sustained over treatment. These observed appeared be associated increases RT.

Язык: Английский

---

Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases

Materials Today Chemistry, Год журнала: 2025, Номер 44, С. 102540 - 102540

Опубликована: Янв. 22, 2025

Язык: Английский

---

Frontier applications of retinal nanomedicine: progress, challenges and perspectives

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Язык: Английский

---

Functional Evolution of Gold Nanoclusters under Light‐Induction: From Fluorescence to Multi‐Enzyme Mimetic Transition

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) laccase-like functionalities. The POD-like activity enables sensitive glucose detection human serum, the capability facilitates simultaneous degradation of phenolic pollutants wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging intrinsic catalytic properties. findings elucidate photo-regulation mechanisms nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable biosensing environmental remediation. work advances development adaptive nanomaterials programmable features biomedical ecological applications.

Язык: Английский

---