Current understanding of the human microbiome

Nature Medicine, Год журнала: 2018, Номер 24(4), С. 392 - 400

Опубликована: Апрель 1, 2018

Язык: Английский

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Best practices for analysing microbiomes

Nature Reviews Microbiology, Год журнала: 2018, Номер 16(7), С. 410 - 422

Опубликована: Май 23, 2018

Язык: Английский

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Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2020, Номер 17(4), С. 223 - 237

Опубликована: Фев. 19, 2020

Язык: Английский

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Large-scale association analyses identify host factors influencing human gut microbiome composition

Nature Genetics, Год журнала: 2021, Номер 53(2), С. 156 - 165

Опубликована: Янв. 18, 2021

Язык: Английский

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Drinking Water Nitrate and Human Health: An Updated Review

International Journal of Environmental Research and Public Health, Год журнала: 2018, Номер 15(7), С. 1557 - 1557

Опубликована: Июль 23, 2018

Nitrate levels in our water resources have increased many areas of the world largely due to applications inorganic fertilizer and animal manure agricultural areas. The regulatory limit for nitrate public drinking supplies was set protect against infant methemoglobinemia, but other health effects were not considered. Risk specific cancers birth defects may be when is ingested under conditions that increase formation N-nitroso compounds. We previously reviewed epidemiologic studies before 2005 intake from cancer, adverse reproductive outcomes effects. Since review, more than 30 evaluated these outcomes. most common endpoints studied colorectal bladder, breast cancer (three each), thyroid disease (four studies). Considering all studies, strongest evidence a relationship between ingestion (besides methemoglobinemia) disease, neural tube defects. Many observed risk with below limits. Future should include improved exposure assessment accurate characterization individual factors affect endogenous nitrosation.

Язык: Английский

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Enterotypes in the landscape of gut microbial community composition

Nature Microbiology, Год журнала: 2017, Номер 3(1), С. 8 - 16

Опубликована: Дек. 13, 2017

Язык: Английский

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The microbiome and human cancer

Science, Год журнала: 2021, Номер 371(6536)

Опубликована: Март 25, 2021

Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies provocatively claimed that bacteria, viruses, and/or fungi are pervasive among cancers, key actors immunotherapy, engineerable to treat metastases. Despite these findings, the number of microbes known directly cause carcinogenesis remains small. Critically evaluating building frameworks such evidence light modern biology is an important task. In this Review, we delineate between causal complicit trace common themes their influence through host's immune system, herein defined as immuno-oncology-microbiome axis. We further review intratumoral approaches manipulate gut or tumor microbiome while projecting next phase experimental discovery.

Язык: Английский

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The Human Gut Microbiome: From Association to Modulation

Cell, Год журнала: 2018, Номер 172(6), С. 1198 - 1215

Опубликована: Март 1, 2018

Язык: Английский

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Global diversity and biogeography of bacterial communities in wastewater treatment plants

Nature Microbiology, Год журнала: 2019, Номер 4(7), С. 1183 - 1195

Опубликована: Май 13, 2019

Язык: Английский

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A practical guide to amplicon and metagenomic analysis of microbiome data

Protein & Cell, Год журнала: 2020, Номер 12(5), С. 315 - 330

Опубликована: Май 11, 2020

Abstract Advances in high-throughput sequencing (HTS) have fostered rapid developments the field of microbiome research, and massive datasets are now being generated. However, diversity software tools complexity analysis pipelines make it difficult to access this field. Here, we systematically summarize advantages limitations methods. Then, recommend specific for amplicon metagenomic analyses, describe commonly-used databases, help researchers select appropriate tools. Furthermore, introduce statistical visualization methods suitable analysis, including alpha- beta-diversity, taxonomic composition, difference comparisons, correlation, networks, machine learning, evolution, source tracing, common styles informed choices. Finally, a step-by-step reproducible guide is introduced. We hope review will allow carry out data more effectively quickly order efficiently mine biological significance behind data.

Язык: Английский

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