Nature Reviews Neurology, Год журнала: 2022, Номер 18(8), С. 497 - 507
Опубликована: Июнь 9, 2022
Язык: Английский
ACS Chemical Neuroscience, Год журнала: 2018, Номер 10(2), С. 792 - 802
Опубликована: Ноя. 6, 2018
Apoptosis and autophagy are important intracellular processes that maintain organism homeostasis promote survival. Autophagy selectively degrades damaged cellular organelles protein aggregates, while apoptosis removes or aged cells. Maintaining a balance between is critical for cell fate, especially long-lived cells such as neurons. Conversely, their imbalance associated with neurodegenerative diseases Parkinson's disease (PD), which characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Restoring promising strategy treatment PD. Some core proteins engage cross talk autophagy, including B lymphoma (BCL)-2 family members. This Review summarizes role BCL-2 members regulation discusses potential therapeutic approaches target this PD treatment.
Язык: Английский
Процитировано
119
Frontiers in Cellular Neuroscience, Год журнала: 2019, Номер 13
Опубликована: Ноя. 19, 2019
Mounting evidence suggests that neuroinflammation is not just a consequence but vital contributor to the development and progression of Parkinson's disease (PD). Microglia in particular, may contribute induction modulation inflammation PD. Upon stimulation, microglia convert into activated phenotypes, which exist along dynamic continuum bear different immune properties depending on stage severity. Activated release various factors involved neuroinflammation, such as cytokines, chemokines, growth factors, reactive oxygen species (ROS) nitrogen (RNS), prostaglandins (PGs). Further, interact with other cell types (e.g. neurons, astrocytes mast cells) are closely associated α-synuclein (α-syn) pathophysiology iron homeostasis disturbance. Taken together, microglial activation microglia-mediated inflammatory responses play essential roles pathogenesis PD elucidation complexity imbalance shed light novel therapeutic approaches for
Язык: Английский
Процитировано
114
Biochemical and Biophysical Research Communications, Год журнала: 2019, Номер 522(2), С. 388 - 394
Опубликована: Ноя. 21, 2019
Язык: Английский
Процитировано
102
European Journal of Medicinal Chemistry, Год журнала: 2020, Номер 211, С. 113102 - 113102
Опубликована: Дек. 18, 2020
Язык: Английский
Процитировано
97
Biomolecules, Год журнала: 2020, Номер 10(9), С. 1327 - 1327
Опубликована: Сен. 16, 2020
Extracellular vesicles (EVs) are naturally occurring membranous structures secreted by normal and diseased cells, carrying a wide range of bioactive molecules. In the central nervous system (CNS), EVs important in both homeostasis pathology. Through receptor–ligand interactions, direct fusion, or endocytosis, interact with their target cells. Accumulating evidence indicates that play crucial roles pathogenesis many neurodegenerative disorders (NDs), including Parkinson′s disease (PD). PD is second most common ND, characterized progressive loss dopaminergic (DAergic) neurons within Substantia Nigra pars compacta (SNpc). PD, glial either beneficial detrimental effects, via complex program cell-to-cell communication. The functions from etiopathogenetic relevance to use as diagnostic tools innovative carriers therapeutics. Because they can cross blood–brain barrier, be engineered deliver molecules (e.g., small interfering RNAs, catalase) CNS. This review summarizes latest findings regarding role played etiology, diagnosis, prognosis, therapy, particular focus on novel nanotherapeutics.
Язык: Английский
Процитировано
92
Aging, Год журнала: 2021, Номер 13(8), С. 11738 - 11751
Опубликована: Апрель 20, 2021
Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in diseases. We explored neuroprotective effect quercetin vivo 6-hydroxydopamine (6-OHDA)-lesioned rat model PD vitro 6-OHDA-treated PC12 cells. In vitro, we found (20 μM) treatment improved quality control, reduced oxidative stress, increased levels markers PINK1 Parkin decreased α-synuclein protein expression Moreover, our findings demonstrated administration also relieved 6-OHDA-induced progressive PD-like motor behaviors, mitigated neuronal death damage accumulation rats. Furthermore, was suppressed by knockdown either Pink1 or Parkin.
Язык: Английский
Процитировано
86
Neural Regeneration Research, Год журнала: 2021, Номер 16(9), С. 1730 - 1730
Опубликована: Янв. 1, 2021
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite availability symptomatic treatments, response towards health PD patients remains scarce. To fulfil medical needs patients, an efficacious and etiological treatment required. In this review, we have compiled information covering limitations current therapeutic options in PD, novel drug targets for finally, role some critical beneficial natural products to control progression PD.
Язык: Английский
Процитировано
85
Biomolecules, Год журнала: 2021, Номер 11(5), С. 767 - 767
Опубликована: Май 20, 2021
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common cause pathological mechanism in many NDs. Several studies have shown interacts with misfolded proteins such as amyloid beta-peptide (Aβ), linked Alzheimer’s disease (AD), α-synuclein, Parkinson’s (PD). To date, NDs constitute serious public health problem, causing financial burden for care systems worldwide. Although current treatments provide symptomatic relief, they do not stop or even slow progression these devastating disorders. Therefore, there an urgent need develop effective drugs incurable ailments. It expected targeting can serve therapeutic strategy since neurodegeneration. In this context, may offer great opportunities drug discovery review critically discusses role provides updated information on scientific evidence potentially be used fatal brain
Язык: Английский
Процитировано
74
Nano-Micro Letters, Год журнала: 2022, Номер 14(1)
Опубликована: Апрель 15, 2022
Abstract Parkinson’s disease (PD), a neurodegenerative that shows high incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there no clinical cure for PD, and novel anti-PD drugs are therefore urgently required. However, the selective permeability of blood–brain barrier (BBB) poses huge challenge development such drugs. Fortunately, through strategies based on physiological characteristics BBB other modifications, including enhancement permeability, nanotechnology can offer solution to this problem facilitate drug delivery across BBB. Although nanomaterials often used as carriers PD treatment, their biological activity ignored. Several studies recent years have shown improve symptoms via own nano-bio effects. In review, we first summarize features then discuss design appropriate brain-targeted nanoplatforms treatment. Subsequently, highlight emerging crossing with nano-biological Finally, current challenges nanomaterial-based treatment future trends field. Our review emphasizes value patents could guide researchers working area future.
Язык: Английский
Процитировано
64
Aging and Disease, Год журнала: 2021, Номер 12(5), С. 1211 - 1211
Опубликована: Янв. 1, 2021
Parkinson's disease (PD) is the second most widespread neurodegenerative disorder in world. It has been reported that exosomes derived from mesenchymal stem cells (MSCs) can contribute to recovery of PD. However, underlying mechanism remains poorly defined. In this study, proteomics and time-series analysis showed MSCs keep human brain microvascular endothelial (HBMECs) a transcriptionally active state, which may be beneficial for angiogenesis. Next, we found MSC-derived promote angiogenesis HBMECs by increasing expression ICAM1, alleviate damage caused 1-methyl-4-phenylpyridinium (MPP+) these cells. Accordingly, when ICAM1 was knocked down, tube formation ability obviously decreased. addition, activating SMAD3 P38MAPK signaling pathways. PD mouse model, were promoting ICAM1-related These findings demonstrate exosome-ICAM1-SMAD3/P38MAPK axis HBMECs, with possible therapeutic potential
Язык: Английский
Процитировано
62