Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(8), P. 497 - 507
Published: June 9, 2022
Language: Английский
ACS Chemical Neuroscience, Journal Year: 2018, Volume and Issue: 10(2), P. 792 - 802
Published: Nov. 6, 2018
Apoptosis and autophagy are important intracellular processes that maintain organism homeostasis promote survival. Autophagy selectively degrades damaged cellular organelles protein aggregates, while apoptosis removes or aged cells. Maintaining a balance between is critical for cell fate, especially long-lived cells such as neurons. Conversely, their imbalance associated with neurodegenerative diseases Parkinson's disease (PD), which characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Restoring promising strategy treatment PD. Some core proteins engage cross talk autophagy, including B lymphoma (BCL)-2 family members. This Review summarizes role BCL-2 members regulation discusses potential therapeutic approaches target this PD treatment.
Language: Английский
Citations
119
Frontiers in Cellular Neuroscience, Journal Year: 2019, Volume and Issue: 13
Published: Nov. 19, 2019
Mounting evidence suggests that neuroinflammation is not just a consequence but vital contributor to the development and progression of Parkinson's disease (PD). Microglia in particular, may contribute induction modulation inflammation PD. Upon stimulation, microglia convert into activated phenotypes, which exist along dynamic continuum bear different immune properties depending on stage severity. Activated release various factors involved neuroinflammation, such as cytokines, chemokines, growth factors, reactive oxygen species (ROS) nitrogen (RNS), prostaglandins (PGs). Further, interact with other cell types (e.g. neurons, astrocytes mast cells) are closely associated α-synuclein (α-syn) pathophysiology iron homeostasis disturbance. Taken together, microglial activation microglia-mediated inflammatory responses play essential roles pathogenesis PD elucidation complexity imbalance shed light novel therapeutic approaches for
Language: Английский
Citations
114
Biochemical and Biophysical Research Communications, Journal Year: 2019, Volume and Issue: 522(2), P. 388 - 394
Published: Nov. 21, 2019
Language: Английский
Citations
102
European Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 211, P. 113102 - 113102
Published: Dec. 18, 2020
Language: Английский
Citations
97
Biomolecules, Journal Year: 2020, Volume and Issue: 10(9), P. 1327 - 1327
Published: Sept. 16, 2020
Extracellular vesicles (EVs) are naturally occurring membranous structures secreted by normal and diseased cells, carrying a wide range of bioactive molecules. In the central nervous system (CNS), EVs important in both homeostasis pathology. Through receptor–ligand interactions, direct fusion, or endocytosis, interact with their target cells. Accumulating evidence indicates that play crucial roles pathogenesis many neurodegenerative disorders (NDs), including Parkinson′s disease (PD). PD is second most common ND, characterized progressive loss dopaminergic (DAergic) neurons within Substantia Nigra pars compacta (SNpc). PD, glial either beneficial detrimental effects, via complex program cell-to-cell communication. The functions from etiopathogenetic relevance to use as diagnostic tools innovative carriers therapeutics. Because they can cross blood–brain barrier, be engineered deliver molecules (e.g., small interfering RNAs, catalase) CNS. This review summarizes latest findings regarding role played etiology, diagnosis, prognosis, therapy, particular focus on novel nanotherapeutics.
Language: Английский
Citations
92
Aging, Journal Year: 2021, Volume and Issue: 13(8), P. 11738 - 11751
Published: April 20, 2021
Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in diseases. We explored neuroprotective effect quercetin vivo 6-hydroxydopamine (6-OHDA)-lesioned rat model PD vitro 6-OHDA-treated PC12 cells. In vitro, we found (20 μM) treatment improved quality control, reduced oxidative stress, increased levels markers PINK1 Parkin decreased α-synuclein protein expression Moreover, our findings demonstrated administration also relieved 6-OHDA-induced progressive PD-like motor behaviors, mitigated neuronal death damage accumulation rats. Furthermore, was suppressed by knockdown either Pink1 or Parkin.
Language: Английский
Citations
86
Neural Regeneration Research, Journal Year: 2021, Volume and Issue: 16(9), P. 1730 - 1730
Published: Jan. 1, 2021
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite availability symptomatic treatments, response towards health PD patients remains scarce. To fulfil medical needs patients, an efficacious and etiological treatment required. In this review, we have compiled information covering limitations current therapeutic options in PD, novel drug targets for finally, role some critical beneficial natural products to control progression PD.
Language: Английский
Citations
85
Biomolecules, Journal Year: 2021, Volume and Issue: 11(5), P. 767 - 767
Published: May 20, 2021
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common cause pathological mechanism in many NDs. Several studies have shown interacts with misfolded proteins such as amyloid beta-peptide (Aβ), linked Alzheimer’s disease (AD), α-synuclein, Parkinson’s (PD). To date, NDs constitute serious public health problem, causing financial burden for care systems worldwide. Although current treatments provide symptomatic relief, they do not stop or even slow progression these devastating disorders. Therefore, there an urgent need develop effective drugs incurable ailments. It expected targeting can serve therapeutic strategy since neurodegeneration. In this context, may offer great opportunities drug discovery review critically discusses role provides updated information on scientific evidence potentially be used fatal brain
Language: Английский
Citations
74
Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)
Published: April 15, 2022
Abstract Parkinson’s disease (PD), a neurodegenerative that shows high incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there no clinical cure for PD, and novel anti-PD drugs are therefore urgently required. However, the selective permeability of blood–brain barrier (BBB) poses huge challenge development such drugs. Fortunately, through strategies based on physiological characteristics BBB other modifications, including enhancement permeability, nanotechnology can offer solution to this problem facilitate drug delivery across BBB. Although nanomaterials often used as carriers PD treatment, their biological activity ignored. Several studies recent years have shown improve symptoms via own nano-bio effects. In review, we first summarize features then discuss design appropriate brain-targeted nanoplatforms treatment. Subsequently, highlight emerging crossing with nano-biological Finally, current challenges nanomaterial-based treatment future trends field. Our review emphasizes value patents could guide researchers working area future.
Language: Английский
Citations
64
Aging and Disease, Journal Year: 2021, Volume and Issue: 12(5), P. 1211 - 1211
Published: Jan. 1, 2021
Parkinson's disease (PD) is the second most widespread neurodegenerative disorder in world. It has been reported that exosomes derived from mesenchymal stem cells (MSCs) can contribute to recovery of PD. However, underlying mechanism remains poorly defined. In this study, proteomics and time-series analysis showed MSCs keep human brain microvascular endothelial (HBMECs) a transcriptionally active state, which may be beneficial for angiogenesis. Next, we found MSC-derived promote angiogenesis HBMECs by increasing expression ICAM1, alleviate damage caused 1-methyl-4-phenylpyridinium (MPP+) these cells. Accordingly, when ICAM1 was knocked down, tube formation ability obviously decreased. addition, activating SMAD3 P38MAPK signaling pathways. PD mouse model, were promoting ICAM1-related These findings demonstrate exosome-ICAM1-SMAD3/P38MAPK axis HBMECs, with possible therapeutic potential
Language: Английский
Citations
62