LTP and LTD

Neuron, Год журнала: 2004, Номер 44(1), С. 5 - 21

Опубликована: Сен. 1, 2004

Язык: Английский

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Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Neuropsychopharmacology, Год журнала: 2007, Номер 33(1), С. 18 - 41

Опубликована: Авг. 29, 2007

Язык: Английский

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Dietary phenolics: chemistry, bioavailability and effects on health

Natural Product Reports, Год журнала: 2009, Номер 26(8), С. 1001 - 1001

Опубликована: Янв. 1, 2009

Covering: up to the end of 2008

Язык: Английский

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TrkB signalling pathways in LTP and learning

Nature reviews. Neuroscience, Год журнала: 2009, Номер 10(12), С. 850 - 860

Опубликована: Ноя. 20, 2009

Язык: Английский

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The Cell Biology of Synaptic Plasticity: AMPA Receptor Trafficking

Annual Review of Cell and Developmental Biology, Год журнала: 2007, Номер 23(1), С. 613 - 643

Опубликована: Июль 31, 2007

The cellular processes that govern neuronal function are highly complex, with many basic cell biological pathways uniquely adapted to perform the elaborate information processing achieved by brain. This is particularly evident in trafficking and regulation of membrane proteins from synapses, which can be a long distance away body number thousands. neurotransmitter receptors, such as AMPA-type glutamate receptors (AMPARs), major excitatory brain, crucial mechanism for modulation synaptic transmission. levels AMPARs at synapses very dynamic, it these plastic changes thought underlie storage Thus, understanding machinery controls AMPAR will critical basis behavior well neurological diseases. Here we describe life cycle AMPARs, their biogenesis, through journey synapse, ultimately demise, discuss how this process essential brain function.

Язык: Английский

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Dopamine: Functions, Signaling, and Association with Neurological Diseases

Cellular and Molecular Neurobiology, Год журнала: 2018, Номер 39(1), С. 31 - 59

Опубликована: Ноя. 16, 2018

Язык: Английский

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A simple role for BDNF in learning and memory?

Frontiers in Molecular Neuroscience, Год журнала: 2010, Номер unknown

Опубликована: Янв. 1, 2010

Since its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in differentiation and survival of neurons CNS. More recently, BDNF also emerged as an important regulator synaptogenesis synaptic plasticity mechanisms underlying learning memory adult In this review we will discuss our knowledge about multiple intracellular signalling pathways activated by BDNF, role long-term formation well synaptogenesis. We show that maturation cellular localisation ability to regulate both excitatory inhibitory synapses CNS may result conflicting alterations formation. Lack a precise which influences higher cognitive functions complex behaviours constitute severe limitation possibility devise BDNF-based therapeutics for human disorders

Язык: Английский

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Neurobiology of the incubation of drug craving

Trends in Neurosciences, Год журнала: 2011, Номер 34(8), С. 411 - 420

Опубликована: Июль 24, 2011

Язык: Английский

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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

Proceedings of the National Academy of Sciences, Год журнала: 2004, Номер 102(2), С. 491 - 496

Опубликована: Дек. 17, 2004

Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter plasticity corticostriatal glutamatergic transmission. This mechanism implies key molecular alterations neurons which both and glutamate inputs are activated. Extracellular signal-regulated kinase (ERK), an enzyme important for long-term synaptic plasticity, is a good candidate playing such role. Here, we show mouse that d -amphetamine activates ERK subset medium-size spiny dorsal striatum through combined action NMDA D1-dopamine receptors. Activation or widely abused drugs, including cocaine, nicotine, morphine, Δ 9 -tetrahydrocannabinol was absent mice lacking dopamine- cAMP-regulated phosphoprotein M r 32,000 (DARPP-32). The cocaine on activation striatum, but not prefrontal cortex, were prevented point mutation Thr-34, DARPP-32 residue specifically involved protein phosphatase-1 inhibition. Regulation occurred upstream at level striatal-enriched tyrosine phosphatase (STEP). Blockade pathway altered locomotor sensitization induced single injection psychostimulants, demonstrating functional relevance this regulation. Thus, ERK, multilevel phosphatase-controlled mechanism, functions as detector coincidence signals converging striatal critical long-lasting abuse.

Язык: Английский

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Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways

Journal of Neuroscience, Год журнала: 2005, Номер 25(49), С. 11288 - 11299

Опубликована: Дек. 7, 2005

Dendritic arborization and spine formation are critical for the functioning of neurons. Although many proteins have been identified recently as regulators dendritic morphogenesis, intracellular signaling pathways that control these processes not well understood. Here we report Ras–phosphatidylinositol 3-kinase (PI3K)–Akt–mammalian target rapamycin (mTOR) pathway plays pivotal roles in regulation aspects dendrite formation. Whereas PI3K–Akt–mTOR alone controlled soma size, a coordinated activation together with Ras-mitogen-activated protein kinase was required increasing complexity. Chronic inhibition PI3K or mTOR reduced size complexity, density filopodia spines, whereas short-term promoted mushroom-shaped spines on cells expressing constitutively active mutants Ras, PI3K, Akt, treated upstream activator BDNF. Together, our data underscore central role spatiotemporally regulated key cell survival growth trophic development shape.

Язык: Английский

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