Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Language: Английский

---

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

---

Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(6), P. 1118 - 1133.e12

Published: June 1, 2023

Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and activates type I interferon signaling plays an essential role in antitumor immunity. However, it remains unclear whether cGAS-mediated activity affected by nutrient status. Here, our study reports that methionine deprivation enhances cGAS blocking its methylation, which catalyzed methyltransferase SUV39H1. We further show methylation chromatin sequestration of a UHRF1-dependent manner. Blocking immunity suppresses colorectal tumorigenesis. Clinically, human cancers correlates with poor prognosis. Thus, results indicate stress promotes activation via reversible suggest potential therapeutic strategy targeting cancer treatment.

Language: Английский

---

Utilization of the microbiome in personalized medicine

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(5), P. 291 - 308

Published: Dec. 18, 2023

Language: Английский

---

Strategies for the development of metalloimmunotherapies

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(9), P. 1073 - 1091

Published: June 24, 2024

Language: Английский

---

Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(3), P. 495 - 500

Published: March 1, 2024

Abstract The intestinal epithelium is the first line of defense and acts as an interface between vast microbial world within gastrointestinal tract body’s internal milieu. not only facilitates nutrient absorption but also plays a key role in defending against pathogens regulating immune system. Central to maintaining healthy are stem cells (ISCs), which essential for replenishing throughout individual’s lifespan. Recent research has unveiled intricate interplay ISCs their niche, includes various cell types, extracellular components, signaling molecules. In this review, we delve into most recent advances ISC research, with focus on roles mucosal homeostasis how functionality influenced by niche environment. explored regulatory mechanisms that govern behavior, emphasizing dynamic adaptability face challenges. Understanding regulation impact aging environmental factors crucial advancing our knowledge developing translational approaches. Future studies should investigate interactive effects different risk function develop strategies improving regenerative capacity gut.

Language: Английский

---

Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases

Nutrients, Journal Year: 2022, Volume and Issue: 15(1), P. 47 - 47

Published: Dec. 22, 2022

An increasing number of studies suggest that diet plays an important role in regulating aging processes and modulates the development most age-related diseases.The aim this review is to provide overview relationship between nutrition critical age-associated diseases.A literature was conducted survey recent pre-clinical clinical findings related nutritional factors modulation fundamental cellular molecular mechanisms their prevention genesis diseases aging.Studies show cardiovascular cerebrovascular diseases, neurodegenerative cognitive impairment dementia can be slowed down or prevented by certain diets with anti-aging action. The protective effects diets, at least part, may mediated beneficial macro- (protein, fat, carbohydrate) micronutrient (vitamins, minerals) composition.Certain such as Mediterranean diet, play a significant healthy preventing onset improving process itself. This latter strengthened incorporating fasting elements into diet. As dietary recommendations change age, should taken consideration well, when developing tailored needs elderly individuals. Future ongoing on complex interventions translating results preclinical investigations are expected lead novel guidelines for older adults near future.

Language: Английский

---

Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 21, 2023

Diet may influence biological aging and the discrepancy (∆age) between a subject's age (BA) chronological (CA). We aimed to investigate correlation of dietary flavonoids with ∆age organs (heart, kidney, liver) whole body.A total 3193 United States adults were extracted from National Health Nutrition Examination Survey (NHANES) in 2007-2008 2017-2018. Dietary intake was assessed using 24-h recall method. Multiple linear regression analysis performed evaluate association body. BA computed based on circulating biomarkers, resulting tested as an outcome analysis.The body, heart, liver inversely associated higher (the body β = - 0.58, cardiovascular 0.96, 3.19) after adjustment for variables. However, positively related renal (β 0.40) participants chronic kidney disease (CKD). Associations influenced by population characteristics, such age, health behavior, or diseases. Anthocyanidins, isoflavones flavones had strongest inverse associations among all subclasses.Flavonoids contributes delaying process, especially organ, which be beneficial reducing long-term risk disease.

Language: Английский

---

Adipose tissue macrophages: implications for obesity-associated cancer

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Jan. 3, 2023

Abstract Obesity is one of the most serious global health problems, with an incidence that increases yearly and coincides development cancer. Adipose tissue macrophages (ATMs) are particularly important in this context contribute to linking obesity-related inflammation tumor progression. However, functions ATMs on progression obesity-associated cancer remain unclear. In review, we describe origins, phenotypes, ATMs. Subsequently, summarize potential mechanisms reprogramming microenvironment, including direct exchange dysfunctional metabolites, inordinate cytokines other signaling mediators, transfer extracellular vesicle cargo, variations gut microbiota its metabolites. A better understanding properties under conditions obesity will lead new therapeutic interventions for

Language: Английский

---

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6020 - 6020

Published: Aug. 11, 2023

Food supplementation formulations refer to products that are designed provide additional nutrients the diet. Vitamins, dietary fibers, minerals and other functional compounds (such as antioxidants) concentrated in supplements. Specific amounts of given body through food supplements, these include well so-called non-essential such secondary plant bioactive components or microbial natural addition narrower sense. A significant social challenge represents how moderately use resources light growing world population. In terms economic production (especially natural) molecules, ways white biotechnology with various microorganisms have recently been intensively explored. current review relevant supplements substances (e.g., vitamins, amino acids, used their via fermentative biotechnological approaches briefly reviewed. Biotechnology plays a crucial role optimizing fermentation conditions maximize yield quality target compounds. Advantages ability renewable feedstocks, high yields, potential for cost-effective large-scale production. Additionally, it can be more environmentally friendly compared chemical synthesis, reduces reliance on petrochemicals minimizes waste generation. Educating consumers about benefits, safety, methods general is crucial. Providing clear accurate information science behind help address any concerns misconceptions may have.

Language: Английский

---