Social Psychiatry and Psychiatric Epidemiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
Язык: Английский
European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Март 11, 2024
Abstract Childhood maltreatment is a risk factor for psychopathologies, and influences brain development at specific periods, particularly during early childhood adolescence. This narrative review addresses phenotypic alterations in sensory systems associated with types of exposure, periods vulnerability to the neurobiological effects maltreatment, relationships between structure, function, connectivity, network architecture; psychopathology; resilience. It also maternal communication attachment disturbances, uses laboratory-based measures infancy case–control studies elucidate reactive disorders children histories. Moreover, we on acute oxytocin disorder methylation regulatory genes. Epigenetic changes may play critical role initiating or producing atypical structural functional maltreatment. However, these could be reversed through psychological pharmacological interventions, by anticipating preventing emergence subsequent psychopathological risks.
Язык: Английский
Процитировано
24
Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 61, С. 101256 - 101256
Опубликована: Май 18, 2023
Early-life adversity has profound consequences for youth neurodevelopment and adjustment; however, experiences of are heterogeneous interrelated in complex ways that can be difficult to operationalize organize developmental research. We sought characterize the underlying dimensional structure co-occurring adverse among a subset (ages 9–10) from Adolescent Brain Cognitive Development (ABCD) Study (N = 7115), community sample United States. identified 60 environmental experiential variables reflect experiences. Exploratory factor analysis 10 robust dimensions early-life co-occurrence, corresponding conceptual domains such as caregiver substance use biological separation, psychopathology, lack support, socioeconomic disadvantage / neighborhood safety. These demonstrated distinct associations with internalizing problems, externalizing cognitive flexibility, inhibitory control. Non-metric multidimensional scaling characterized qualitative similarity dimensions. Results supported nonlinear three-dimensional representing adversity, including continuous gradients "perspective", "environmental uncertainty", "acts omission/commission". Our findings suggest there co-occurrence ABCD at baseline, resulting may have unique implications behavior.
Язык: Английский
Процитировано
25
Biological Psychiatry, Год журнала: 2024, Номер 97(1), С. 64 - 72
Опубликована: Июль 29, 2024
BackgroundDifferent types of early-life adversity have been associated with children's brain structure and function. However, understanding the disparate influence distinct exposures on developing remains a major challenge.MethodsThis study investigates neural correlates 10 robust dimensions identified through exploratory factor analysis in large community sample youth from Adolescent Brain Cognitive Development (ABCD) Study. age models were trained, validated, tested separately T1-weighted (T1; N = 9524), diffusion tensor (DTI; 8834), resting-state functional (rs-fMRI; 8233) magnetic resonance imaging (MRI) data two time points (mean 10.7 years, SD 1.2, range 8.9-13.8 years).ResultsBayesian multilevel modelling supported associations between different younger- older-looking brains. Dimensions generally related to emotional neglect, such as lack primary secondary caregiver support, supervision, lower gaps (BAGs), i.e., younger-looking In contrast, psychopathology, trauma exposure, family aggression, substance use separation biological parent, socio-economic disadvantage neighbourhood safety higher BAGs, brains.ConclusionsThe findings suggest that are differentially neurodevelopmental patterns, indicative dimension-specific delayed accelerated maturation.
Язык: Английский
Процитировано
10
Child and Adolescent Mental Health, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Background Exposure to adversity (e.g., negative life events) and socioeconomic disadvantage can increase the risk for internalizing externalizing symptoms, but many youth demonstrate resilience. Risk protective factors may vary depending on geographic contexts (i.e., urban vs. rural areas). We hypothesized that community cohesion would mitigate effects of mental health especially among communities. Method Data were drawn from Adolescent Brain Cognitive Development ( ABCD ) Study n = 10,812), a longitudinal study in United States. At baseline (9–10 years old), neighborhood was measured with Area Deprivation Index, reported total number events they had experienced. 2‐year follow‐up, caregivers within their community, at 3‐year child's symptomatology. A multiple‐group path model used compare living versus areas. Results In subsample, results indicated significant interaction between β −.03, p .004), such higher associated (but not internalizing) symptomatology low medium, high, levels cohesion. identified similar patterns neared conventional significance thresholds −.09, .052). There no adversity. Conclusions Community serve as factor experiencing by mitigating symptoms.
Язык: Английский
Процитировано
1
Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер 174, С. 106176 - 106176
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
1
Clinical Psychology Review, Год журнала: 2023, Номер 103, С. 102301 - 102301
Опубликована: Июнь 5, 2023
Язык: Английский
Процитировано
22
Epigenomics, Год журнала: 2025, Номер unknown, С. 1 - 16
Опубликована: Янв. 17, 2025
Suicide continues to be a significant public health issue globally, claiming over 700,000 lives annually. It is, therefore, important assess the suicide risk properly and provide intervention in timely fashion. While heritability of suicidal behavior is around 50%, it does not explain factors involved causality. Recent evidence suggests that gene x environment interaction plays vital role behavior. In this paper, we critically evaluate association between adolescent epigenetic modifications, including DNA methylation, histone modification, non-coding RNAs, as well epigenetic-based treatment options. was noted prevalence adolescents varied by age sex presence psychiatric disorders. Childhood adversity closely associated with Studies show alterations modifications may increase independent mental illnesses. Because are reversible, environmental enrichment or use pharmacological agents can target specific modulation able reduce population.
Язык: Английский
Процитировано
1
Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 31
Опубликована: Апрель 8, 2024
Growing evidence supports the unique pathways by which threat and deprivation, two core dimensions of adversity, confer risk for youth psychopathology. However, extent to these differ in their direct associations with psychopathology remains unclear. The primary aim this preregistered meta-analysis was synthesize between threat, internalizing, externalizing, trauma-specific Because is proposed be directly linked socioemotional development, we hypothesized that magnitude would larger than those deprivation. We conducted a search peer-reviewed articles English using PubMed PsycINFO databases through August 2022. Studies assessed both deprivation used previously validated measures were included. One hundred twenty-seven included synthesis (
Язык: Английский
Процитировано
5
Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 378(1885)
Опубликована: Июль 24, 2023
Cognition underpins the flexibility of human eating and disruption to higher cognitive processes, such as inhibitory control memory, can result in increased food intake, which long term could weight gain. The aim this review is provide an overview current evidence on cognition a causal factor development obesity humans. Evidence from meta-analyses supports suggestion that function cross-sectionally associated with even when controlling for range confounding variables. However, association be explained by reverse causality because there also metabolic syndrome history excess western diet consumption alters brain structure function. Data longitudinal interventional studies non-human animal models suggest reciprocal relationship between exists but whether processes primary cause humans remains unclear. This article part discussion meeting issue 'Causes obesity: theories, conjectures (Part I)'.
Язык: Английский
Процитировано
10
Journal of Affective Disorders, Год журнала: 2024, Номер 364, С. 305 - 313
Опубликована: Авг. 12, 2024
Язык: Английский
Процитировано
4