The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke DOI Open Access
Susana Delgado‐Martín, Antonio Martínez‐Ruiz

FEBS Letters, Год журнала: 2024, Номер unknown

Опубликована: Апрель 26, 2024

Ferroptosis is a unique form of cell death that was first described in 2012 and plays significant role various diseases, including neurodegenerative conditions. It depends on dysregulation cellular iron metabolism, which increases free, redox-active, can trigger Fenton reactions, generating hydroxyl radicals damage cells through oxidative stress lipid peroxidation. Lipid peroxides, resulting mainly from unsaturated fatty acids, by disrupting membrane integrity propagating signals. Moreover, peroxide degradation products further affect components such as DNA, proteins, amines. In ischemic stroke, where blood flow to the brain restricted, there increased absorption, stress, compromised blood-brain barrier integrity. Imbalances iron-transport -storage proteins increase oxidation contribute neuronal damage, thus pointing possibility cells, especially neurons, dying ferroptosis. Here, we review evidence showing ferroptosis both recent studies directly assessing this type death, well previous now be revisited with our new knowledge mechanisms. We also efforts made target stroke possible treatment mitigate death.

Язык: Английский

The Chemical Reactivity of Membrane Lipids DOI Creative Commons
Geneviève Duché, John M. Sanderson

Chemical Reviews, Год журнала: 2024, Номер 124(6), С. 3284 - 3330

Опубликована: Март 18, 2024

It is well-known that aqueous dispersions of phospholipids spontaneously assemble into bilayer structures.These structures have numerous applications across chemistry and materials science form the fundamental structural unit biological membrane.The particular environment lipid bilayer, with a water-poor low dielectric core surrounded by more polar better hydrated interfacial region, gives membrane biophysical physicochemical properties presents unique for chemical reactions to occur.Many different types molecule spanning range sizes, from dissolved gases through small organics proteins, are able interact membranes promote changes lipids subsequently affect bilayer.This Review describes reactivity exhibited in their form, an emphasis on conditions where well bilayers.Key topics include following: lytic glyceryl esters, including hydrolysis, aminolysis, transesterification; oxidation alkenes unsaturated fatty acids sterols, autoxidation singlet oxygen; headgroups, particularly reactive carbonyl species; E/Z isomerization alkenes.The consequences activity also discussed.

Язык: Английский

Процитировано

18
Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance DOI Creative Commons
Hongquan Wang, Joshua S. Fleishman,

Sihang Cheng

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 27, 2024

Abstract The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, unique type regulated cell death, plays pivotal role inhibiting tumour growth, presenting new opportunities treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine vulnerability to ferroptosis. In this review, we first summarize the growth/development. Then, core molecular mechanisms ferroptosis, its upstream regulation, and downstream effects on Finally, review recent advances understanding how ncRNAs regulate ferroptosis from such modulate This aims enhance general ncRNA-mediated regulatory which highlighting ncRNA-ferroptosis axis as key druggable target overcoming

Язык: Английский

Процитировано

16
Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy DOI
Ying Hou, Heng Wang, Jiarui Wu

и другие.

Medicinal Research Reviews, Год журнала: 2024, Номер 44(4), С. 1566 - 1595

Опубликована: Янв. 29, 2024

Lung cancer is a major cause of morbidity and mortality. The specific pulmonary structure to directly connect with ambient air makes it more susceptible damage from airborne toxins. External oxidative stimuli endogenous reactive oxygen species (ROS) play crucial role in promoting lung carcinogenesis development. biological properties higher ROS levels tumor cells than normal make them sensitive vulnerable injury. Therefore, the strategy targeting has been proposed for therapy decades. However, embarrassing that countless attempts at ROS-based therapies have had very limited success, no FDA approval anticancer list was mechanistically based on manipulation. Even compared untargetable proteins, such as transcription factors, are difficult be targeted due their chemical properties. Thus, pleiotropic roles provide therapeutic potential drug discovery, while better dissection mechanistic action signaling pathways prerequisite future breakthroughs. This review discusses critical carcinogenesis, ROS-inspired pathways, treatment, exemplified by cancer. In particular, an eight considerations rule ROS-targeting strategies design

Язык: Английский

Процитировано

13
Emerging roles of ferroptosis in pulmonary fibrosis: current perspectives, opportunities and challenges DOI Creative Commons
Yixiang Hu,

Ying Huang,

Lijuan Zong

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Июнь 24, 2024

Abstract Pulmonary fibrosis (PF) is a chronic interstitial lung disorder characterized by abnormal myofibroblast activation, accumulation of extracellular matrix (ECM), and thickening fibrotic alveolar walls, resulting in deteriorated function. PF initiated dysregulated wound healing processes triggered factors such as excessive inflammation, oxidative stress, coronavirus disease (COVID-19). Despite advancements understanding the disease’s pathogenesis, effective preventive therapeutic interventions are currently lacking. Ferroptosis, an iron-dependent regulated cell death (RCD) mechanism involving lipid peroxidation glutathione (GSH) depletion, exhibits unique features distinct from other RCD forms (e.g., apoptosis, necrosis, pyroptosis). Imbalance between reactive oxygen species (ROS) production detoxification leads to ferroptosis, causing cellular dysfunction through peroxidation, protein modifications, DNA damage. Emerging evidence points crucial role ferroptosis progression, driving macrophage polarization, fibroblast proliferation, ECM deposition, ultimately contributing tissue scarring. This review provides comprehensive overview latest findings on involvement signaling mechanisms emphasizing potential novel anti-fibrotic approaches targeting for management.

Язык: Английский

Процитировано

13
A Self‐Catalytic NO/O2 Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief DOI Open Access
Shuyu Wang,

Miaomiao Cheng,

Shenghui Wang

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted "prosthetic-Arginine" coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O

Язык: Английский

Процитировано

13
The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency DOI Open Access
George J. Kontoghiorghes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4654 - 4654

Опубликована: Апрель 25, 2024

The supply and control of iron is essential for all cells vital many physiological processes. All functions activities are expressed in conjunction with iron-binding molecules. For example, natural chelators such as transferrin chelator–iron complexes haem play major roles metabolism human physiology. Similarly, the mainstay treatments most common diseases metabolism, namely deficiency anaemia overload, involve iron–chelator iron-chelating drugs deferiprone (L1), deferoxamine (DF) deferasirox. Endogenous citric acid glutathione exogenous ascorbic also important homeostasis. Recent advances treatment effective ferric tri-maltol complex (feraccru or accrufer) transfusional overload using L1 L1/DF combinations have decreased associated mortality morbidity improved quality life millions patients. Many other chelating ciclopirox, dexrazoxane EDTA used daily by patients diseases. their metabolites iron-chelation capacity hydroxyurea, tetracyclines, anthracyclines aspirin, well dietary molecules gallic acid, caffeic quercetin, ellagic maltol phytochelators, known to interact affect related Different interactions observed presence essential, xenobiotic, diagnostic theranostic metal ions competing iron. Clinical trials Parkinson’s, Alzheimer’s neurodegenerative diseases, HIV infections, cancer, diabetic nephropathy inflammation, highlight importance chelation therapy clinical conditions. proposed use modulating ferroptosis signifies a new era design therapeutic strategies introduction artificial intelligence guidance optimal outcomes personalised medicine expected increase further impact medicine, survival metabolic disorders

Язык: Английский

Процитировано

11
Ferroptosis in Cancer: Mechanisms, Therapeutic Strategies, and Clinical Implications DOI

Mina Pourhabib Mamaghani,

Seyedeh Nasibeh Mousavikia,

Hosein Azimian

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер 269, С. 155907 - 155907

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

2
Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction DOI
Jiaqi Li, Huang Siqing, Qin Wang

и другие.

Phytomedicine, Год журнала: 2022, Номер 109, С. 154601 - 154601

Опубликована: Дек. 11, 2022

Язык: Английский

Процитировано

36
Acidity‐Biodegradable Iridium‐Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways DOI
Lili Huang,

Tongtong Nie,

Lixian Jiang

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(10)

Опубликована: Янв. 7, 2023

Abstract Ferroptosis‐based treatment strategies display the potential to suppress some malignant tumors with intrinsic apoptosis resistance. However, current related cancer treatments are still hampered by insufficient intracellular reactive oxygen species (ROS) levels and Fe 2+ contents, posing considerable challenges for their clinical translation. Herein, an acid‐biodegradable iridium‐coordinated nanosheets (Ir‐Hemin) sonodynamic therapy (SDT) properties effectively induce ferroptosis in tumor cells through multiple regulatory pathways proposed. Under ultrasound (US) irradiation, Ir‐Hemin act as nanosonosensitizers generate ROS, subsequently causing accumulation of lipid peroxides (LPO) inducing ferroptotic cell death. Furthermore, these decompose quickly release hemin Ir(IV), which deplete glutathione (GSH) deactivate enzyme peroxidase 4 (GPX4) initiate pathway. Specifically, released enables heme oxygenase 1 (HO‐1) upregulation endogenous ferrous ion supplementation, compensates toxicity concerns brought about large uptake exogenous iron. Surprisingly, exhibit high trigger effective therapy. These pronounced synergistic anticancer efficacy under US stimulation both vitro vivo, providing a strong rationale application treatment.

Язык: Английский

Процитировано

21
Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs DOI Creative Commons
Qi Zhang,

Xinfeng Fan,

Xinyu Zhang

и другие.

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Июль 29, 2023

Abstract Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance body homeostasis and pathological processes. Ferroptosis is a novel form PCD characterized by the accumulation iron-dependent lipid peroxides resulting lethal damage. It contributes to tumor progression apoptosis-independent manner. In recent years, increasing number non-coding RNAs (ncRNAs) have been demonstrated mediate biological process ferroptosis, hence impacting carcinogenesis, progression, drug resistance, prognosis. However, clear regulatory mechanism for this phenomenon remains poorly understood. Moreover, ferroptosis does not usually exist independently. Its interaction with PCD, like apoptosis, necroptosis, autophagy, pyroptosis, cuproptosis, destroy cells appears exist. Furthermore, ncRNA seems be involved. Here, we review mechanisms which occurs, dissect its relationship other forms death, summarize key roles played ncRNAs, raise relevant questions predict possible barriers application clinic, offering new ideas targeted tumour therapy.

Язык: Английский

Процитировано

21