Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)

Published: Sept. 22, 2023

Abstract Kidney diseases remain one of the leading causes human death and have placed a heavy burden on medical system. Regulated cell contributes to pathology plethora renal diseases. Recently, with in-depth studies into kidney death, new iron-dependent modality, known as ferroptosis, has been identified attracted considerable attention among researchers in pathogenesis therapeutics treat them. The majority suggest that ferroptosis plays an important role pathologies multiple diseases, such acute injury (AKI), chronic disease, carcinoma. In this review, we summarize recently regulatory molecular mechanisms discuss pathways action various describe protective effect inhibitors against especially AKI. By summarizing prominent roles different progress made studying provide directions strategies for future research summary, ferroptotic factors are potential targets therapeutic intervention alleviate targeting them may lead treatments patients

Language: Английский

---

The Chemical Reactivity of Membrane Lipids

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(6), P. 3284 - 3330

Published: March 18, 2024

It is well-known that aqueous dispersions of phospholipids spontaneously assemble into bilayer structures.These structures have numerous applications across chemistry and materials science form the fundamental structural unit biological membrane.The particular environment lipid bilayer, with a water-poor low dielectric core surrounded by more polar better hydrated interfacial region, gives membrane biophysical physicochemical properties presents unique for chemical reactions to occur.Many different types molecule spanning range sizes, from dissolved gases through small organics proteins, are able interact membranes promote changes lipids subsequently affect bilayer.This Review describes reactivity exhibited in their form, an emphasis on conditions where well bilayers.Key topics include following: lytic glyceryl esters, including hydrolysis, aminolysis, transesterification; oxidation alkenes unsaturated fatty acids sterols, autoxidation singlet oxygen; headgroups, particularly reactive carbonyl species; E/Z isomerization alkenes.The consequences activity also discussed.

Language: Английский

---

Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 27, 2024

Abstract The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, unique type regulated cell death, plays pivotal role inhibiting tumour growth, presenting new opportunities treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine vulnerability to ferroptosis. In this review, we first summarize the growth/development. Then, core molecular mechanisms ferroptosis, its upstream regulation, and downstream effects on Finally, review recent advances understanding how ncRNAs regulate ferroptosis from such modulate This aims enhance general ncRNA-mediated regulatory which highlighting ncRNA-ferroptosis axis as key druggable target overcoming

Language: Английский

---

Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1566 - 1595

Published: Jan. 29, 2024

Lung cancer is a major cause of morbidity and mortality. The specific pulmonary structure to directly connect with ambient air makes it more susceptible damage from airborne toxins. External oxidative stimuli endogenous reactive oxygen species (ROS) play crucial role in promoting lung carcinogenesis development. biological properties higher ROS levels tumor cells than normal make them sensitive vulnerable injury. Therefore, the strategy targeting has been proposed for therapy decades. However, embarrassing that countless attempts at ROS-based therapies have had very limited success, no FDA approval anticancer list was mechanistically based on manipulation. Even compared untargetable proteins, such as transcription factors, are difficult be targeted due their chemical properties. Thus, pleiotropic roles provide therapeutic potential drug discovery, while better dissection mechanistic action signaling pathways prerequisite future breakthroughs. This review discusses critical carcinogenesis, ROS-inspired pathways, treatment, exemplified by cancer. In particular, an eight considerations rule ROS-targeting strategies design

Language: Английский

---

A Self‐Catalytic NO/O₂ Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted "prosthetic-Arginine" coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O

Language: Английский

---

The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4654 - 4654

Published: April 25, 2024

The supply and control of iron is essential for all cells vital many physiological processes. All functions activities are expressed in conjunction with iron-binding molecules. For example, natural chelators such as transferrin chelator–iron complexes haem play major roles metabolism human physiology. Similarly, the mainstay treatments most common diseases metabolism, namely deficiency anaemia overload, involve iron–chelator iron-chelating drugs deferiprone (L1), deferoxamine (DF) deferasirox. Endogenous citric acid glutathione exogenous ascorbic also important homeostasis. Recent advances treatment effective ferric tri-maltol complex (feraccru or accrufer) transfusional overload using L1 L1/DF combinations have decreased associated mortality morbidity improved quality life millions patients. Many other chelating ciclopirox, dexrazoxane EDTA used daily by patients diseases. their metabolites iron-chelation capacity hydroxyurea, tetracyclines, anthracyclines aspirin, well dietary molecules gallic acid, caffeic quercetin, ellagic maltol phytochelators, known to interact affect related Different interactions observed presence essential, xenobiotic, diagnostic theranostic metal ions competing iron. Clinical trials Parkinson’s, Alzheimer’s neurodegenerative diseases, HIV infections, cancer, diabetic nephropathy inflammation, highlight importance chelation therapy clinical conditions. proposed use modulating ferroptosis signifies a new era design therapeutic strategies introduction artificial intelligence guidance optimal outcomes personalised medicine expected increase further impact medicine, survival metabolic disorders

Language: Английский

---

Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

---

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

Phytomedicine, Journal Year: 2022, Volume and Issue: 109, P. 154601 - 154601

Published: Dec. 11, 2022

Language: Английский

---

Acidity‐Biodegradable Iridium‐Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(10)

Published: Jan. 7, 2023

Abstract Ferroptosis‐based treatment strategies display the potential to suppress some malignant tumors with intrinsic apoptosis resistance. However, current related cancer treatments are still hampered by insufficient intracellular reactive oxygen species (ROS) levels and Fe 2+ contents, posing considerable challenges for their clinical translation. Herein, an acid‐biodegradable iridium‐coordinated nanosheets (Ir‐Hemin) sonodynamic therapy (SDT) properties effectively induce ferroptosis in tumor cells through multiple regulatory pathways proposed. Under ultrasound (US) irradiation, Ir‐Hemin act as nanosonosensitizers generate ROS, subsequently causing accumulation of lipid peroxides (LPO) inducing ferroptotic cell death. Furthermore, these decompose quickly release hemin Ir(IV), which deplete glutathione (GSH) deactivate enzyme peroxidase 4 (GPX4) initiate pathway. Specifically, released enables heme oxygenase 1 (HO‐1) upregulation endogenous ferrous ion supplementation, compensates toxicity concerns brought about large uptake exogenous iron. Surprisingly, exhibit high trigger effective therapy. These pronounced synergistic anticancer efficacy under US stimulation both vitro vivo, providing a strong rationale application treatment.

Language: Английский

---

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 5043 - 5043

Published: Oct. 19, 2023

Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest it promising of tumor cell death. regulated by iron metabolism, lipid intracellular reducing substances, which the mechanism basis its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) 1O2 through type I II photochemical reactions, subsequently induces ferroptosis Fenton reaction peroxidation membrane lipids. kills cells generating excessive cytotoxic ROS. Due to limited laser depth photosensitizer enrichment, systemic treatment effect not good. Combining can compensate for these shortcomings. Nanoparticles constructed photosensitizers agonists are widely used field therapy, their targeting biological safety be improved modification. These nanoparticles only directly kill but also further exert synergistic activating antitumor immunity, improving hypoxia microenvironment, inhibiting angiogenesis. Ferroptosis-agonist-induced chemotherapy PDT-induced ablation have good clinical application prospects. In this review, we summarize current research progress on how promote each other.

Language: Английский

---