Ferritinophagy in the etiopathogenic mechanism of related diseases

The Journal of Nutritional Biochemistry, Год журнала: 2023, Номер 117, С. 109339 - 109339

Опубликована: Апрель 13, 2023

Язык: Английский

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Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Авг. 22, 2023

Abstract Endometriosis is strongly associated with infertility. Several mechanisms have been reported in an attempt to elucidate the pathophysiological effects that lead reduced fertility women endometriosis. However, by which endometriosis affects not fully elucidated. Ferroptosis a novel form of nonapoptotic cell death characterized iron-dependent lipid peroxidation membrane damage. In past reports, elevated iron levels ectopic lesions, peritoneal fluid and follicular patients The high-iron environment closely ferroptosis, appears exhibit double-edged effect on can cause damage ovarian granulosa cells, oocytes, embryos, leading endometriosis-related This article summarizes main pathways regulatory ferroptosis explores possible formation iron-overloaded endometriotic fluid. Finally, we reviewed recent studies potential

Язык: Английский

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Regulated Cell Death in Endometriosis

Biomolecules, Год журнала: 2024, Номер 14(2), С. 142 - 142

Опубликована: Янв. 23, 2024

Regulated cell death (RCD) represents a distinct mode of demise, differing from accidental (ACD), characterized by specific signaling cascades orchestrated diverse biomolecules. The regular process plays crucial role in upholding internal homeostasis, acting as safeguard against biological or chemical damage. Nonetheless, programmed deaths have the potential to activate an immune–inflammatory response, potentially contributing diseases enlisting immune cells and releasing pro-inflammatory factors. Endometriosis, prevalent gynecological ailment, remains incompletely understood despite substantial progress unraveling associated pathways. Its complexity is intricately tied dysregulation inflammatory responses, with various RCD processes such apoptosis, autophagic death, pyroptosis, ferroptosis implicated its development. Notably, limited research explores association between endometriosis pathways like pyroptosis cuproptosis. exploration regulated context holds tremendous for further advancements. This article thoroughly reviews molecular mechanisms governed their implications endometriosis. A comprehensive understanding mechanism has catalyze development promising therapeutic strategies chart course future directions field.

Язык: Английский

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Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application

Microbiological Research, Год журнала: 2024, Номер 282, С. 127667 - 127667

Опубликована: Март 1, 2024

Язык: Английский

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Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6298 - 6298

Опубликована: Июнь 7, 2024

Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility caused by a wide range abnormalities affecting the female reproductive tract, from oocyte quality impairment disturbances eutopic endometrium or mechanical resulting disease progression. Since supportive antioxidant therapies, addition surgical treatment assisted techniques (ARTs), have overall been proven be effective tools endometriosis management, objective our review was analyze role substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, endometriosis-related infertility. Most these substances alleviate systemic oxidant predominance, which has expressed through decreased oxidative stress (OS) markers enhanced antioxidative defense. In addition, we demonstrated that predominant effect aforementioned inhibition development endometriotic lesions as well suppression pro-inflammatory molecules. Although can undoubtedly conclude antioxidants are beneficial fertility support, further studies explaining detailed pathways their action needed.

Язык: Английский

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Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature

Medicine, Год журнала: 2024, Номер 103(11), С. e37421 - e37421

Опубликована: Март 15, 2024

Endometriosis (EMT) a common gynecological condition in women, an inflammatory disease characterized by the presence of endometrial tissue on organs and tissues pelvis, is mainly associated with chronic pelvic pain infertility. As etiology has not been fully elucidated, current treatment limited to surgery, hormones painkillers, more side effects difficulty achieving long-term relief. Oxidative stress manifests itself as overproduction reactive oxygen species, which integral impact pathology female reproductive disorders. In this review, we evaluate mechanisms iron overload-induced oxidative ferroptosis EMT their pathophysiological implications.

Язык: Английский

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The crosstalk between exosomes and ferroptosis: a review

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Апрель 9, 2024

Abstract Exosomes are a subtype of extracellular vesicles composed bioactive molecules, including nucleic acids, proteins, and lipids. generated by the fusion intracellular multivesicular bodies (MVBs) with cell membrane subsequently released into space to participate in intercellular communication diverse biological processes within target cells. As crucial mediator, exosomes have been implicated regulating ferroptosis—an iron-dependent programmed death characterized lipid peroxide accumulation induced reactive oxygen species. The involvement iron, lipid, amino acid metabolism contributes their regulatory role specific mechanisms underlying how modulate ferroptosis, which remains incompletely understood, some related studies still preliminary. Therefore, targeting regulation ferroptosis holds promise for future clinical treatment strategies across various diseases. This review aims provide insights pathophysiology governing interaction between implications disease development serve as reference further research.

Язык: Английский

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Exploration and breakthrough in the mode of chondrocyte death - A potential new mechanism for osteoarthritis

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 115990 - 115990

Опубликована: Дек. 6, 2023

Osteoarthritis (OA) is a frequent chronic joint disease in orthopedics that effects individuals and society significantly. Obesity, aging, genetic susceptibility, misalignment are all known risk factors for OA, but its pathomechanism still poorly understood. Researches have revealed OA much complex process related to inflammation, metabolic chondrocyte death. It can affect parts of the characterized by causing death extracellular matrix descent. Previously, was thought develop from excessive mechanical loading leading destruction articular cartilage. Since some programmed cell deaths share pattern destruction, it likely also involves Even though apoptosis pyroptosis been investigated clarifing solely conventional pathways insufficient understand pathophysiology osteoarthritis. With more researches, has discovered osteoarthritis other new processes, including PANoptosis, ferroptosis, senescence, strongly associated. Among these, PANoptosis combines key traits pyroptosis, apoptosis, necrotic into highly coordinated dynamically balanced inflammatory mechanism. Furthermore, we think PANopotosis might obstruct necroptosis senescence. Therefore, order offer direction therapeutic treatment, evaluate development research on multiple chondrocytes OA.

Язык: Английский

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A matter of new life and cell death: programmed cell death in the mammalian ovary

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Март 20, 2024

The mammalian ovary is a unique organ that displays distinctive feature of cyclic changes throughout the entire reproductive period. estrous/menstrual cycles are associated with drastic functional and morphological rearrangements ovarian tissue, including follicular development degeneration, formation subsequent atrophy corpus luteum. flawless execution these reiterative processes impossible without involvement programmed cell death (PCD).

Язык: Английский

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Mechanisms of chondrocyte cell death in osteoarthritis: implications for disease progression and treatment

Journal of Orthopaedic Surgery and Research, Год журнала: 2024, Номер 19(1)

Опубликована: Сен. 9, 2024

Osteoarthritis (OA) is a chronic joint disease characterized by the degeneration, destruction, and excessive ossification of articular cartilage. The prevalence OA rising annually, concomitant with aging global population increasing rates obesity. This condition imposes substantial escalating burden on individual health, healthcare systems, broader social economic frameworks. etiology multifaceted not fully understood. Current research suggests that death chondrocytes, encompassing mechanisms such as cellular apoptosis, pyroptosis, autophagy, ferroptosis cuproptosis, contributes to both initiation progression disease. These cell pathways only diminish chondrocytes but also exacerbate damage through induction inflammation other deleterious processes. paper delineates morphological characteristics associated various modes summarizes current results molecular different patterns in OA. objective review advancements understanding chondrocyte OA, thereby offering novel insights for potential clinical interventions.

Язык: Английский

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