Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(9)
Опубликована: Авг. 7, 2023
With
the
increasing
prevalence
of
cancer
and
toxic
side
effects
synthetic
drugs,
natural
products
are
being
developed
as
promising
therapeutic
approaches.
Gracillin
is
a
naturally
occurring
triterpenoid
steroidal
saponin
with
several
activities.
It
obtained
major
compound
from
different
Dioscorea
species.
This
review
was
designated
to
summarize
research
progress
on
anti-cancer
activities
gracillin
focusing
underlying
cellular
molecular
mechanisms,
well
its
pharmacokinetic
features.
The
data
were
collected
(up
date
May
1,
2023)
various
reliable
authentic
literatures
comprising
PubMed,
Springer
Link,
Scopus,
Wiley
Online,
Web
Science,
ScienceDirect,
Google
Scholar.
findings
demonstrated
that
displays
anticancer
through
including
anti-inflammatory
effects,
apoptotic
cell
death,
induction
oxidative
stress,
cytotoxicity,
genotoxicity,
cycle
arrest,
anti-proliferative
effect,
autophagy,
inhibition
glycolysis,
blocking
migration.
Additionally,
this
highlighted
features
gracillin,
indicating
lower
oral
bioavailability.
As
conclusion,
it
can
be
proposed
could
serve
hopeful
chemotherapeutic
agent.
However,
further
extensive
clinical
recommended
establish
safety,
efficacy,
potential
in
treatment.
Abstract
Cell
death
regulation
is
essential
for
tissue
homeostasis
and
its
dysregulation
often
underlies
cancer
development.
Understanding
the
different
pathways
of
cell
can
provide
novel
therapeutic
strategies
battling
cancer.
This
review
explores
several
key
mechanisms
apoptosis,
necroptosis,
autophagic
death,
ferroptosis,
pyroptosis.
The
research
gap
addressed
involves
a
thorough
analysis
how
these
be
precisely
targeted
therapy,
considering
tumor
heterogeneity
adaptation.
It
delves
into
genetic
epigenetic
factors
signaling
cascades
like
phosphatidylinositol
3‐kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
mitogen‐activated
protein
kinase/extracellular
signal‐regulated
(MAPK/ERK)
pathways,
which
are
critical
death.
Additionally,
interaction
microenvironment
with
cells,
particularly
influence
hypoxia,
nutrient
deprivation,
immune
cellular
interactions,
explored.
Emphasizing
strategies,
this
highlights
emerging
modulators
inducers
such
as
B
lymphoma
2
(BCL2)
homology
domain
3
(BH3)
mimetics,
tumour
necrosis
factor‐related
apoptosis‐inducing
ligand
(TRAIL),
chloroquine,
innovative
approaches
to
induce
ferroptosis
provides
insights
therapy's
future
direction,
focusing
on
multifaceted
circumvent
drug
resistance.
examination
evolving
underlines
considerable
clinical
potential
continuous
necessity
in‐depth
exploration
within
scientific
domain.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(4), С. 1566 - 1595
Опубликована: Янв. 29, 2024
Lung
cancer
is
a
major
cause
of
morbidity
and
mortality.
The
specific
pulmonary
structure
to
directly
connect
with
ambient
air
makes
it
more
susceptible
damage
from
airborne
toxins.
External
oxidative
stimuli
endogenous
reactive
oxygen
species
(ROS)
play
crucial
role
in
promoting
lung
carcinogenesis
development.
biological
properties
higher
ROS
levels
tumor
cells
than
normal
make
them
sensitive
vulnerable
injury.
Therefore,
the
strategy
targeting
has
been
proposed
for
therapy
decades.
However,
embarrassing
that
countless
attempts
at
ROS-based
therapies
have
had
very
limited
success,
no
FDA
approval
anticancer
list
was
mechanistically
based
on
manipulation.
Even
compared
untargetable
proteins,
such
as
transcription
factors,
are
difficult
be
targeted
due
their
chemical
properties.
Thus,
pleiotropic
roles
provide
therapeutic
potential
drug
discovery,
while
better
dissection
mechanistic
action
signaling
pathways
prerequisite
future
breakthroughs.
This
review
discusses
critical
carcinogenesis,
ROS-inspired
pathways,
treatment,
exemplified
by
cancer.
In
particular,
an
eight
considerations
rule
ROS-targeting
strategies
design
Proteomes,
Год журнала:
2025,
Номер
13(1), С. 6 - 6
Опубликована: Янв. 20, 2025
The
tumor
suppressor
p53,
in
its
wild-type
form,
plays
a
central
role
cellular
homeostasis
by
regulating
senescence,
apoptosis,
and
autophagy
within
the
DNA
damage
response
(DDR).
Recent
findings
suggest
that
p53
also
governs
ferroptosis,
an
iron-dependent
cell
death
process
driven
lipid
peroxidation.
Post-translational
modifications
of
generate
proteoforms
significantly
enhance
functional
diversity
these
mechanisms.
A
key
target
this
is
cystine/glutamate
transporter
(xCT),
which
essential
for
redox
balance
ferroptosis
resistance.
Additionally,
p53-induced
miR-34c-5p
suppresses
cancer
proliferation
drug
resistance
modulating
Myc,
oncogene
further
influenced
non-coding
RNAs
like
circular
RNA
NOTCH1
(CricNOTCH1)
long
MALAT1.
However,
exact
molecules
remains
unclear.
To
address
this,
we
introduce
first
dynamic
Boolean
model
delineates
influence
ncRNAs
on
senescence
DDR
context.
Validated
through
gain-
loss-of-function
perturbations,
our
closely
aligns
with
experimental
observations
cancers
such
as
oral
squamous
carcinoma,
nasopharyngeal
osteosarcoma.
identifies
crucial
positive
feedback
loops
(CricNOTCH1/miR-34c/Myc,
MALAT1/miR-34c/Myc,
Myc/xCT)
highlights
therapeutic
potential
using
to
combat
induce
death.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 26, 2025
Lung
cancer
(LC)
is
a
highly
prevalent
and
deadly
type
of
characterized
by
intricate
molecular
pathways
that
drive
tumor
development,
metastasis,
resistance
to
conventional
treatments.
Recently,
ferroptosis,
controlled
mechanism
cell
death
instigated
iron-dependent
lipid
peroxidation,
has
gained
attention
for
its
role
in
LC
progression
treatment.
Noncoding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs)
long
noncoding
(lncRNAs),
are
emerging
key
modulators
significantly
influencing
biology.
This
review
explores
how
ncRNAs
control
ferroptotic
affect
growth,
therapy
LC.
By
understanding
the
dual
functions
both
activating
inhibiting
we
aim
uncover
new
therapeutic
targets
strategies
These
insights
provide
promising
direction
development
ncRNA-based
treatments
designed
induce
potentially
improving
outcomes
patients
with
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 22, 2024
Ferroptosis
is
caused
by
the
accumulation
of
cellular
reactive
oxygen
species
that
exceed
antioxidant
load
glutathione
(GSH)
and
phospholipid
hydroperoxidases
with
GSH-based
substrates
can
carry
When
capacity
cells
reduced,
lipid
accumulate,
which
cause
oxidative
death.
Ferroptosis,
an
iron-dependent
regulatory
necrosis
pathway,
has
emerged
as
a
new
modality
cell
death
strongly
associated
cancer.
Surgery,
chemotherapy
radiotherapy
are
main
methods
cancer
treatment.
However,
resistance
to
these
mainstream
anticancer
drugs
strong
toxic
side
effects
have
forced
development
alternative
treatments
high
efficiency
low
toxicity.
In
recent
years,
increasing
number
studies
shown
traditional
Chinese
medicines
(TCMs),
especially
herbs
or
herbal
extracts,
inhibit
tumor
growth
metastasis
inducing
ferroptosis,
suggesting
they
could
be
promising
agents
for
This
article
reviews
current
research
progress
on
antitumor
TCMs
through
induction
ferroptosis.
The
aim
was
elucidate
potential
mechanisms
targeting
ferroptosis
in
cancer,
findings
lead
directions
reference
values
developing
better
treatment
strategies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 23, 2024
Lung
cancer
is
the
leading
cause
of
global
cancer-related
deaths.
Platinum-based
chemotherapy
first-line
treatment
for
most
common
type
lung
cancer,
i.e.,
non-small-cell
(NSCLC),
but
its
therapeutic
efficiency
limited
by
chemotherapeutic
resistance.
Therefore,
it
vital
to
develop
effective
modalities
that
bypass
molecular
mechanisms
associated
with
Ferroptosis
a
form
non-apoptotic
regulated
cell
death
characterized
iron-dependent
lipid
peroxidation
(LPO).
crucial
proper
efficacy
cancer-associated
chemotherapies.
If
targeted
as
novel
mechanism,
ferroptosis
modulators
present
new
opportunities
increasing
chemotherapy.
Emerging
studies
have
revealed
pharmacological
induction
using
natural
compounds
boosts
in
or
drug-resistant
cancer.
In
this
review,
we
first
discuss
resistance
(or
chemoresistance)
and
introduce
core
behind
ferroptosis.
Then,
comprehensively
summarize
small-molecule
sourced
from
traditional
medicines
may
boost
anti-tumor
activity
current
agents
overcome
NSCLC.
Cumulatively,
suggest
ferroptosis-related
anticancer
could
serve
starting
point
NSCLC
inducing
ferroptosis,
highlighting
potential
regimens
used
chemoresistance
