Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(2), С. 102952 - 102952
Опубликована: Фев. 1, 2024
Язык: Английский
Nature Reviews Endocrinology, Год журнала: 2022, Номер 19(2), С. 82 - 97
Опубликована: Окт. 24, 2022
Язык: Английский
Процитировано
282
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Июль 23, 2022
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.
Язык: Английский
Процитировано
99
Nature reviews. Cancer, Год журнала: 2022, Номер 22(8), С. 452 - 466
Опубликована: Май 25, 2022
Язык: Английский
Процитировано
94
Cell Metabolism, Год журнала: 2022, Номер 34(10), С. 1457 - 1471.e4
Опубликована: Окт. 1, 2022
Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) high-intensity interval (HIIT) improve cardiometabolic health in at-risk individuals, whether these two interventions combined induce superior improvements glycemic control than each individual intervention is not known. In this four-armed randomized controlled trial (ClinicalTrials.gov NCT04019860), we determined the isolated effects of 7 weeks TRE (≤10-h daily window, with ad libitum energy intake) HIIT (three sessions per week), compared a non-intervention group, on secondary outcomes 131 women (36.2 ± 6.2 years) overweight/obesity. There were no statistically significant after TRE, HIIT, or combination (TREHIIT) glucose area under curve during an oral tolerance test (the outcome) group (TRE, −26.3 mmol/L; 95% confidence [CI], −82.3 to 29.7, p = 0.36; −53.8 CI, −109.2 1.6, 0.057; TREHIIT, −41.3 −96.4 13.8, 0.14). However, TREHIIT improved HbA1c induced reductions total visceral fat mass alone. High participant suggest that thereof may be realistic diet-exercise improving markers metabolic at risk disease.
Язык: Английский
Процитировано
70
Cell Metabolism, Год журнала: 2024, Номер 36(2), С. 301 - 314
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
44
The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 108(7), С. 1824 - 1834
Опубликована: Янв. 26, 2023
Abstract Context It remains controversial whether the choice of daily eating window early or later in time-restricted (TRE) intervention (early TRE) has different effects on weight loss and metabolic health. Objective A network meta-analysis was performed to evaluate efficacy between TRE adults with obesity overweight. Methods We searched PubMed, Embase, Web Science, Cochrane Library for randomized controlled trials (RCTs) published until October 16, 2022. conducted a body parameters, including glycemic metabolism, blood pressure, lipid profiles. Results Twelve RCTs 730 obese overweight were included this meta-analysis. Early both elicited moderate reductions insulin resistance (IR) (homeostasis model assessment IR) when compared non-TRE. Interestingly, showed more effectiveness than improving IR vs TRE: −0.44; 95% CI, −0.86 −0.02; P < .05), whereas no statistically significant difference detected −0.31 kg; −1.15 0.53 >.05). In addition, rather benefits metabolism pressure No differences observed fasting glucose, Conclusion This suggests that people may choose effective management benefits. Nevertheless, further large-scale are warranted verify our findings.
Язык: Английский
Процитировано
41
Nature Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
2
Cell Reports Medicine, Год журнала: 2022, Номер 3(10), С. 100777 - 100777
Опубликована: Окт. 1, 2022
Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial determine effects low-carbohydrate diet (LCD), an 8-h time-restricted (TRE) schedule, and their combination on body weight abdominal fat area (i.e., primary outcomes) cardiometabolic outcomes participants MetS. Compared baseline, all 3-month treatments significantly reduce subcutaneous area, but only TRE treatment visceral (VFA), fasting blood glucose, uric acid (UA), dyslipidemia. Furthermore, compared changes LCD, further decrease VFA, while yields more benefits glycemic control, UA, In conclusion, without change physical activity, or LCD can serve as effective for MetS (ClinicalTrials.gov: NCT04475822).
Язык: Английский
Процитировано
51
Physiological Reviews, Год журнала: 2022, Номер 102(4), С. 1991 - 2034
Опубликована: Июль 14, 2022
Time-restricted eating (TRE) is a dietary intervention that limits food consumption to specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects important interactions among eating, circadian biology, metabolic homeostasis. In contrast, it difficult make firm conclusions regarding the people because heterogeneity results, regimens, study populations. this review, we 1) provide background history meal normal physiology fasting; 2) discuss interaction between molecular metabolism TRE; 3) integrate results preclinical clinical studies evaluated functions; 4) summarize other time-related interventions people; identify current gaps knowledge framework for future research directions.
Язык: Английский
Процитировано
40
The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2022, Номер 107(12), С. 3428 - 3441
Опубликована: Окт. 3, 2022
Abstract Context Time-restricted eating (TRE), which restricts food intake to a limited duration of the day, is key regimen intermittent fasting. Objective The aim our study was provide an up-to-date meta-analysis and systematic review evaluate efficacy TRE on weight loss other metabolic-related parameters in adults. Methods We searched PubMed, EMBASE, Cochrane Library for relevant studies published before February 26, 2022. Study at least 4 weeks. Body continuous were described as weighted mean difference (WMD) with 95% CI. Results Seventeen randomized controlled trials involving 899 participants analyzed. pooled has shown that contributed significant decrease body WMD −1.60 kg (95% CI −2.27 −0.93) fat mass −1.48 −1.59 −1.38). Subgroup analysis showed could reduce especially overweight −1.43 −2.05 −0.81) −1.56 −1.67 −1.44), respectively. also beneficial effects lipid spectrum participants, including decreased levels triglyceride (WMD −12.71 mg/dL, −24.9 −0.52), total cholesterol −6.45 −7.40 −5.49), low-density lipoprotein −7.0 −9.74 −4.25). However, compared control, had no waist circumference, index, glycosylated hemoglobin, or blood pressure. Conclusion This updated found may be effective approach improve metabolic state nonobese subjects, participants.
Язык: Английский
Процитировано
40