Cancer Research,
Год журнала:
2023,
Номер
83(21), С. 3529 - 3543
Опубликована: Авг. 21, 2023
As
a
safe,
feasible,
and
inexpensive
dietary
intervention,
fasting-mimicking
diet
(FMD)
exhibits
excellent
antitumor
efficacy
by
regulating
metabolism
boosting
immunity.
A
better
understanding
of
the
specific
mechanisms
underlying
immunoregulatory
functions
FMD
could
help
improve
expand
clinical
application
FMD-mediated
immunotherapeutic
strategies.
In
this
study,
we
aimed
to
elucidate
role
metabolic
reprogramming
induced
in
activation
immunity
against
colorectal
cancer.
Single-cell
RNA
sequencing
analysis
intratumoral
immune
cells
revealed
that
tumor-infiltrating
IgA+
B
were
significantly
reduced
treatment,
leading
tumor
regression
murine
cancer
models.
Mechanistically,
delayed
growth
repressing
B-cell
class
switching
IgA.
Therefore,
FMD-induced
reduction
overcame
suppression
CD8+
T
cells.
The
effects
intervention
reversed
transfer.
Moreover,
boosted
fatty
acid
oxidation
(FAO)
trigger
RUNX3
acetylation,
thus
inactivating
Cα
gene
transcription
IgA
switching.
expansion
was
also
impeded
patients
placed
on
FMD,
while
expression
carnitine
palmitoyl
transferase
1A
(CPT1A),
rate-limiting
enzyme
FAO,
increased.
Furthermore,
CPT1A
negatively
correlated
with
both
secretion
within
Together,
these
results
highlight
holds
great
promise
for
treating
degree
cell
infiltration
FAO-associated
status
are
potential
biomarkers
evaluating
efficacy.Metabolic
suppresses
production
activate
inhibit
growth.
See
related
commentary
Bush
Perry,
p.
3493.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 20, 2024
Abstract
Tumor
biomarkers,
the
substances
which
are
produced
by
tumors
or
body’s
responses
to
during
tumorigenesis
and
progression,
have
been
demonstrated
possess
critical
encouraging
value
in
screening
early
diagnosis,
prognosis
prediction,
recurrence
detection,
therapeutic
efficacy
monitoring
of
cancers.
Over
past
decades,
continuous
progress
has
made
exploring
discovering
novel,
sensitive,
specific,
accurate
tumor
significantly
promoted
personalized
medicine
improved
outcomes
cancer
patients,
especially
advances
molecular
biology
technologies
developed
for
detection
biomarkers.
Herein,
we
summarize
discovery
development
including
history
conventional
innovative
used
biomarker
classification
biomarkers
based
on
tissue
origins,
application
clinical
management.
In
particular,
highlight
recent
advancements
biomarker-based
anticancer-targeted
therapies
emerging
as
breakthroughs
promising
strategies.
We
also
discuss
limitations
challenges
that
need
be
addressed
provide
insights
perspectives
turn
into
opportunities
this
field.
Collectively,
multiple
emphasized
review
may
guidance
precision
medicine,
broaden
horizons
future
research
directions,
expedite
patients
according
their
rather
than
organs
origin.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Cell Reports Medicine,
Год журнала:
2024,
Номер
5(4), С. 101478 - 101478
Опубликована: Апрель 1, 2024
Immunotherapy
has
emerged
as
a
robust
approach
against
cancer,
yet
its
efficacy
varied
among
individuals,
accompanied
by
the
occurrence
of
immune-related
adverse
events.
As
result,
immunotherapy
is
far
from
satisfactory,
and
enormous
efforts
have
been
invested
to
develop
strategies
improve
patient
outcomes.
The
gut
microbiome
now
well
acknowledged
for
critical
role
in
immunotherapy,
with
better
understanding
on
host-microbes
interaction
context
cancer
treatment.
Also,
an
increasing
number
trials
conducted
evaluate
potential
feasibility
microbiome-targeting
approaches
enhance
treatment
patients.
Here,
metabolites
(e.g.,
short-chain
fatty
acids,
tryptophan
metabolites)
underlying
mechanisms
are
explored.
application
that
aim
fecal
microbiota
transplantation,
probiotics,
dietary
intervention)
also
elaborated,
further
discussion
current
challenges
suggestions
future
research.
Cell Metabolism,
Год журнала:
2024,
Номер
36(6), С. 1371 - 1393.e7
Опубликована: Май 7, 2024
The
role
and
molecular
mechanisms
of
intermittent
fasting
(IF)
in
non-alcoholic
steatohepatitis
(NASH)
its
transition
to
hepatocellular
carcinoma
(HCC)
are
unknown.
Here,
we
identified
that
an
IF
5:2
regimen
prevents
NASH
development
as
well
ameliorates
established
fibrosis
without
affecting
total
calorie
intake.
Furthermore,
the
blunted
NASH-HCC
when
applied
therapeutically.
timing,
length,
number
cycles
type
diet
were
critical
parameters
determining
benefits
fasting.
Combined
proteome,
transcriptome,
metabolome
analyses
peroxisome-proliferator-activated
receptor
alpha
(PPARα)
glucocorticoid-signaling-induced
PCK1
act
co-operatively
hepatic
executors
response.
In
line
with
this,
PPARα
targets
reduced
human
NASH.
Notably,
only
initiated
during
active
phase
mice
robustly
induced
glucocorticoid
signaling
free-fatty-acid-induced
signaling.
However,
hepatocyte-specific
deletion
partially
abrogated
contrast,
combined
knockdown
Ppara
Pck1
vivo
abolished
beneficial
outcomes
against
inflammation
fibrosis.
Moreover,
overexpression
alone
or
together
lowered
triglycerides
steatosis.
Our
data
support
notion
is
a
promising
intervention
subsequent
liver
cancer.
Trends in Pharmacological Sciences,
Год журнала:
2024,
Номер
45(6), С. 537 - 551
Опубликована: Май 17, 2024
Cancer
cells
perturb
lipid
metabolic
pathways
for
a
variety
of
pro-tumorigenic
functions,
and
deregulated
cellular
metabolism
is
hallmark
cancer
cells.
Although
alterations
in
have
been
appreciated
over
20
years,
there
are
no
FDA-approved
treatments
that
target
lipid-related
pathways.
Recent
advances
pertaining
to
cell
fatty
acid
synthesis
(FAS),
desaturation,
uptake,
microenvironmental
dietary
lipids,
tumor-infiltrating
immune
illuminated
promising
clinical
applications
targeting
metabolism.
This
review
highlights
emerging
targets
tumor
may
soon
impact
treatment.
Overnutrition
is
a
risk
factor
for
various
human
diseases,
including
neurodegenerative
metabolic
disorders,
and
cancers.
Therefore,
targeting
overnutrition
represents
simple
but
attractive
strategy
the
treatment
of
these
increasing
public
health
threats.
Fasting
as
dietary
intervention
combating
has
been
extensively
studied.
practiced
millennia,
only
recently
have
its
roles
in
molecular
clock,
gut
microbiome,
tissue
homeostasis
function
emerged.
can
slow
aging
most
species
protect
against
These
centuried
unfading
adventures
explorations
suggest
that
fasting
potential
to
delay
help
prevent
treat
diseases
while
minimizing
side
effects
caused
by
chronic
interventions.
In
this
review,
recent
animal
studies
concerning
role
underlying
mechanism
physiology
pathology
are
summarized,
therapeutic
highlighted,
combination
pharmacological
discussed
new
regimen
diseases.
