Designer
self-assembling
peptides
form
the
entangled
nanofiber
networks
in
hydrogels
by
ionic-complementary
self-assembly.
This
type
of
hydrogel
has
realistic
biological
and
physiochemical
properties
to
serve
as
biomimetic
extracellular
matrix
(ECM)
for
biomedical
applications.
The
advantages
benefits
are
distinct
from
natural
other
synthetic
or
semisynthetic
hydrogels.
provide
diverse
alternatives
main
building
blocks
various
functional
nanostructures.
permit
essential
compositional
complexity
heterogeneity
engineering
cell
microenvironments
comparison
with
hydrogels,
which
may
reconstruct
tumor
(TMEs)
3D
cultures
tissue-specific
modeling
vitro.
Either
ovarian
cancer
progression
recurrence
relapse
involved
multifaceted
TMEs
addition
mesothelial
cells,
fibroblasts,
endothelial
pericytes,
immune
adipocytes,
ECM.
Based
on
progress
common
products,
this
work
focuses
designer
peptide
instructive
constructs
precise
oncology
remodeling
cancer,
issued
several
research
aspects
a
context.
significance
discussed,
some
approaches
coming
challenges
also
addressed
current
complex
diseases.
Advanced Materials,
Год журнала:
2019,
Номер
31(50)
Опубликована: Июль 8, 2019
Abstract
Significant
advances
in
materials,
microscale
technology,
and
stem
cell
biology
have
enabled
the
construction
of
3D
tissues
organs,
which
will
ultimately
lead
to
more
effective
diagnostics
therapy.
Organoids
organs‐on‐a‐chip
(OOC),
evolved
from
developmental
bioengineering
principles,
emerged
as
major
technological
breakthrough
distinct
model
systems
revolutionize
biomedical
research
drug
discovery
by
recapitulating
key
structural
functional
complexity
human
organs
vitro.
There
is
growing
interest
development
biomaterials,
especially
hydrogels,
for
utilization
these
promising
build
physiologically
relevant
with
defined
properties.
The
remarkable
properties
hydrogels
proper
extracellular
matrix
that
can
instruct
cellular
behaviors
are
presented.
recent
trend
where
integrated
into
organoids
OOC
tissue
models
highlighted.
Future
opportunities
perspectives
advanced
toward
accelerating
applications
also
discussed.
Advanced Materials,
Год журнала:
2019,
Номер
32(20)
Опубликована: Ноя. 25, 2019
Soft
matter
systems
and
materials
are
moving
toward
adaptive
interactive
behavior,
which
holds
outstanding
promise
to
make
the
next
generation
of
intelligent
soft
inspired
from
dynamics
behavior
living
systems.
But
what
is
an
material?
What
How
should
classical
responsiveness
or
smart
be
delineated?
At
present,
literature
lacks
a
comprehensive
discussion
on
these
topics,
however
profound
importance
in
order
identify
landmark
advances,
keep
correct
noninflating
terminology,
most
importantly
educate
young
scientists
going
into
this
direction.
By
comparing
different
levels
complex
biological
systems,
Viewpoint
strives
give
some
definition
various
characteristics.
In
particular,
thinking
direction
training
learning
materials,
metabolic
behavioral
highlighted,
as
well
communication
information-processing
This
aims
also
serve
switchboard
further
connect
important
fields
chemistry,
synthetic
biology,
supramolecular
chemistry
nano-
microfabrication/3D
printing
with
advanced
research.
A
convergence
disciplines
will
at
heart
empowering
future
increasingly
emergent
life-like
behavior.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июль 31, 2023
Abstract
Cellular
mechanotransduction,
a
critical
regulator
of
numerous
biological
processes,
is
the
conversion
from
mechanical
signals
to
biochemical
regarding
cell
activities
and
metabolism.
Typical
cues
in
organisms
include
hydrostatic
pressure,
fluid
shear
stress,
tensile
force,
extracellular
matrix
stiffness
or
tissue
elasticity,
viscosity.
Mechanotransduction
has
been
expected
trigger
multiple
such
as
embryonic
development,
repair
regeneration.
However,
prolonged
excessive
stimulation
can
result
pathological
multi-organ
fibrosis,
tumorigenesis,
cancer
immunotherapy
resistance.
Although
associations
between
normal
homeostasis
diseases
have
identified,
regulatory
mechanisms
among
different
are
not
yet
comprehensively
illustrated,
no
effective
therapies
currently
available
targeting
cue-related
signaling.
This
review
systematically
summarizes
characteristics
typical
conditions
with
updated
evidence.
The
key
effectors
responding
stimulations
listed,
Piezo
channels,
integrins,
Yes-associated
protein
(YAP)
/transcriptional
coactivator
PDZ-binding
motif
(TAZ),
transient
receptor
potential
vanilloid
4
(TRPV4).
We
also
reviewed
signaling
pathways,
therapeutic
targets
cutting-edge
clinical
applications
related
cues.
International Wound Journal,
Год журнала:
2022,
Номер
19(7), С. 1934 - 1954
Опубликована: Март 17, 2022
Abstract
Wound
healing
is
a
complex
process
in
tissue
regeneration
through
which
the
body
responds
to
dissipated
cells
as
result
of
any
kind
severe
injury.
Diabetic
and
non‐healing
wounds
are
considered
an
unmet
clinical
need.
Currently,
different
strategic
approaches
widely
used
treatment
acute
chronic
include,
but
not
limited
to,
transplantation,
cell
therapy
wound
dressings,
use
instrument.
A
large
number
literatures
have
been
published
on
this
topic;
however,
most
effective
remains
challenge.
The
dressing
involves
scaffold,
usually
using
biomaterials
for
delivery
medication,
autologous
stem
cells,
or
growth
factors
from
blood.
Antibacterial
anti‐inflammatory
drugs
also
stop
infection
well
accelerate
healing.
With
increase
ageing
population
leading
diabetes
associated
cutaneous
wounds,
there
great
need
improve
current
strategies.
This
research
critically
reviews
advancement
therapeutic
regeneration.
results
recent
trials
suggest
that
modern
dressings
skin
substitutes
easiest,
accessible,
cost‐effective
way
treat
with
advances
materials
science
such
graphene
3D
scaffold
biomolecules
hold
significant
promise.
annual
market
value
successful
exceeds
over
$50
billion
US
dollars,
will
encourage
industries
academics
investigate
application
emerging
smart
therapy.
