Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(12)
Опубликована: Май 14, 2021
Designing
simple
biomaterials
to
replicate
the
biochemical
and
mechanical
properties
of
tissues
is
an
ongoing
challenge
in
tissue
engineering.
For
several
decades,
new
have
been
engineered
using
cytocompatible
chemical
reactions
spontaneous
ligations
via
click
chemistries
generate
scaffolds
water
swollen
polymer
networks,
known
as
hydrogels,
with
tunable
properties.
However,
most
these
materials
are
static
nature,
providing
only
macroscopic
tunability
scaffold
mechanics,
do
not
reflect
dynamic
environment
natural
extracellular
microenvironment.
more
complex
applications
such
organoids
or
co-culture
systems,
there
remain
opportunities
investigate
cells
that
locally
remodel
change
physicochemical
within
matrices.
In
this
review,
advanced
where
covalent
chemistry
used
produce
stable
3D
cell
culture
models
high-resolution
constructs
for
both
vitro
vivo
applications,
discussed.
The
implications
on
viscoelastic
summarized,
case
studies
critically
analyzed,
further
improve
performance
engineering
Materials Science and Engineering R Reports,
Год журнала:
2020,
Номер
140, С. 100543 - 100543
Опубликована: Фев. 18, 2020
3D
printing
alias
additive
manufacturing
can
transform
virtual
models
created
by
computer-aided
design
(CAD)
into
physical
objects
in
a
layer-by-layer
manner
dispensing
with
conventional
molding
or
machining.
Since
the
incipiency,
significant
advancements
have
been
achieved
understanding
process
of
and
relationship
component,
structure,
property
application
objects.
Because
hydrogels
are
one
most
feasible
classes
ink
materials
for
this
field
has
rapidly
advancing,
Review
focuses
on
hydrogel
designs
development
advanced
hydrogel-based
biomaterial
inks
bioinks
printing.
It
covers
techniques
including
laser
(stereolithography,
two-photon
polymerization),
extrusion
(3D
plotting,
direct
writing),
inkjet
printing,
bioprinting,
4D
bioprinting.
provides
comprehensive
overview
discussion
tailorability
material,
mechanical,
physical,
chemical
biological
properties
to
enable
The
range
hydrogel-forming
polymers
covered
encompasses
biopolymers,
synthetic
polymers,
polymer
blends,
nanocomposites,
functional
cell-laden
systems.
representative
biomedical
applications
selected
demonstrate
how
is
being
exploited
tissue
engineering,
regenerative
medicine,
cancer
research,
vitro
disease
modeling,
high-throughput
drug
screening,
surgical
preparation,
soft
robotics
flexible
wearable
electronics.
Incomparable
thermoplastics,
thermosets,
ceramics
metals,
playing
pivotal
role
creation
(bio)systems
customizable
way.
An
outlook
future
directions
presented.
Polymer Chemistry,
Год журнала:
2019,
Номер
11(2), С. 184 - 219
Опубликована: Сен. 25, 2019
We
explore
the
design
and
synthesis
of
hydrogel
scaffolds
for
tissue
engineering
from
perspective
underlying
polymer
chemistry.
The
key
polymers,
properties
architectures
used,
their
effect
on
growth
are
discussed.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Фев. 2, 2021
Abstract
Cellular
models
are
needed
to
study
human
development
and
disease
in
vitro,
screen
drugs
for
toxicity
efficacy.
Current
approaches
limited
the
engineering
of
functional
tissue
with
requisite
cell
densities
heterogeneity
appropriately
model
behaviors.
Here,
we
develop
a
bioprinting
approach
transfer
spheroids
into
self-healing
support
hydrogels
at
high
resolution,
which
enables
their
patterning
fusion
high-cell
density
microtissues
prescribed
spatial
organization.
As
an
example
application,
bioprint
induced
pluripotent
stem
cell-derived
cardiac
microtissue
spatially
controlled
cardiomyocyte
fibroblast
ratios
replicate
structural
features
scarred
that
arise
following
myocardial
infarction,
including
reduced
contractility
irregular
electrical
activity.
The
bioprinted
vitro
is
combined
readouts
probe
how
various
pro-regenerative
microRNA
treatment
regimes
influence
regeneration
recovery
function
as
result
proliferation.
This
method
useful
range
biomedical
applications,
precision
mimic
diseases
screening
drugs,
particularly
where
important.
Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11149 - 11193
Опубликована: Июнь 30, 2021
Owing
to
their
unique
chemical
and
physical
properties,
hydrogels
are
attracting
increasing
attention
in
both
basic
translational
biomedical
studies.
Although
the
classical
with
static
networks
have
been
widely
reported
for
decades,
a
growing
number
of
recent
studies
shown
that
structurally
dynamic
can
better
mimic
dynamics
functions
natural
extracellular
matrix
(ECM)
soft
tissues.
These
synthetic
materials
defined
compositions
recapitulate
key
biophysical
properties
living
tissues,
providing
an
important
means
understanding
mechanisms
by
which
cells
sense
remodel
surrounding
microenvironments.
This
review
begins
overall
expectation
design
principles
hydrogels.
We
then
highlight
progress
fabrication
strategies
including
degradation-dependent
degradation-independent
approaches,
followed
use
applications
such
as
regenerative
medicine,
drug
delivery,
3D
culture.
Finally,
challenges
emerging
trends
development
application
discussed.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(42)
Опубликована: Авг. 18, 2020
Abstract
Hydrogels
are
one
of
the
most
commonly
explored
classes
biomaterials.
Their
chemical
and
structural
versatility
has
enabled
their
use
across
a
wide
range
applications,
including
tissue
engineering,
drug
delivery,
cell
culture.
form
upon
sol–gel
transition,
which
can
be
elicited
by
different
triggers
designed
to
enable
precise
control
over
hydrogelation
kinetics
hydrogel
structure.
The
chosen
trigger
chemistry
have
profound
effect
on
success
targeted
application.
In
this
Progress
Report,
critical
overview
recent
advances
in
design
is
presented,
with
focus
available
strategies
used
formation
networks
(e.g.,
temperature,
light,
ultrasound).
These
presented
within
new
classification
system,
suitability
for
six
key
hydrogel‐based
applications
assessed.
This
Report
intended
guide
selection
inspire
rational
mechanisms.
