Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(33), С. 8007 - 8032
Опубликована: Янв. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
Organoids
are
three-dimensional
(3D)
miniaturized
versions
of
organs
or
tissues
that
derived
from
cells
with
stem
potential
and
can
self-organize
differentiate
into
3D
cell
masses,
recapitulating
the
morphology
functions
their
in
vivo
counterparts.
Organoid
culture
is
an
emerging
technology,
organoids
various
tissues,
such
as
brain,
lung,
heart,
liver,
kidney,
have
been
generated.
Compared
traditional
bidimensional
culture,
organoid
systems
unique
advantage
conserving
parental
gene
expression
mutation
characteristics,
well
long-term
maintenance
function
biological
characteristics
vitro.
All
these
features
open
up
new
opportunities
for
drug
discovery,
large-scale
screening,
precision
medicine.
Another
major
application
disease
modeling,
especially
hereditary
diseases
difficult
to
model
vitro
modeled
by
combining
genome
editing
technologies.
Herein,
we
introduce
development
current
advances
technology
field.
We
focus
on
applications
basic
biology
clinical
research,
also
highlight
limitations
future
perspectives.
hope
this
review
provide
a
valuable
reference
developments
organoids.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(5)
Опубликована: Май 1, 2024
Abstract
The
interplay
between
extracellular
matrix
(ECM)
stiffness
and
the
tumor
microenvironment
is
increasingly
recognized
as
a
critical
factor
in
cancer
progression
efficacy
of
immunotherapy.
This
review
comprehensively
discusses
key
factors
regulating
ECM
remodeling,
including
activation
cancer-associated
fibroblasts
accumulation
crosslinking
proteins.
Furthermore,
it
provides
detailed
exploration
how
influences
behaviors
both
immune
cells.
Significantly,
impact
on
response
to
various
immunotherapy
strategies,
such
checkpoint
blockade,
adoptive
cell
therapy,
oncolytic
virus
therapeutic
vaccines,
thoroughly
examined.
also
addresses
challenges
translating
research
findings
into
clinical
practice,
highlighting
need
for
more
precise
biomaterials
that
accurately
mimic
development
novel
strategies.
insights
offered
aim
guide
future
research,
with
potential
enhance
effectiveness
modalities.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 429 - 444
Опубликована: Фев. 16, 2024
Osteoarthritis
(OA),
a
common
degenerative
disease,
is
characterized
by
high
disability
and
imposes
substantial
economic
impacts
on
individuals
society.
Current
clinical
treatments
remain
inadequate
for
effectively
managing
OA.
Organoids,
miniature
3D
tissue
structures
from
directed
differentiation
of
stem
or
progenitor
cells,
mimic
native
organ
functions.
They
are
useful
drug
testing
serve
as
active
grafts
repair.
However,
organoid
construction
requires
extracellular
matrix-like
scaffolds
cellular
growth.
Hydrogel
microspheres,
with
tunable
physical
chemical
properties,
show
promise
in
cartilage
engineering
replicating
the
natural
microenvironment.
Building
prior
work
SF-DNA
dual-network
hydrogels
regeneration,
we
developed
novel
RGD-SF-DNA
hydrogel
microsphere
(RSD-MS)
via
microfluidic
system
integrating
photopolymerization
self-assembly
techniques
then
modified
Pep-RGDfKA.
The
RSD-MSs
exhibited
uniform
size,
porous
surface,
optimal
swelling
degradation
properties.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Март 1, 2024
The
extracellular
matrix
(ECM)
is
a
highly
complex
structure
through
which
biochemical
and
mechanical
signals
are
transmitted.
In
processes
of
cell
migration,
the
ECM
also
acts
as
scaffold,
providing
structural
support
to
cells
well
points
potential
attachment.
Although
well-studied
structure,
its
role
in
many
biological
remains
difficult
investigate
comprehensively
due
complexity
variation
within
an
organism.
tandem
with
experiments,
mathematical
models
helpful
refining
testing
hypotheses,
generating
predictions,
exploring
conditions
outside
scope
experiments.
Such
can
be
combined
calibrated
vivo
vitro
data
identify
critical
cell-ECM
interactions
that
drive
developmental
homeostatic
processes,
or
progression
diseases.
this
review,
we
focus
on
computational
such
migration
including
cancer
metastasis,
tissue
morphogenesis.
By
highlighting
predictive
power
these
models,
aim
help
bridge
gap
between
experimental
approaches
studying
provide
guidance
selecting
appropriate
model
framework
complement
corresponding
studies.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 21, 2024
The
extracellular
matrix
(ECM)
plays
critical
roles
in
cytoskeletal
support,
biomechanical
transduction
and
biochemical
signal
transformation.
Tumor-associated
macrophage
(TAM)
function
is
regulated
by
stiffness
solid
tumors
often
associated
with
poor
prognosis.
ECM
stiffness-induced
mechanical
cues
can
activate
cell
membrane
mechanoreceptors
corresponding
mechanotransducers
the
cytoplasm,
modulating
phenotype
of
TAMs.
Currently,
tuning
TAM
polarization
through
stimulation
has
received
increasing
attention,
whereas
its
effect
on
fate
rarely
been
summarized.
A
better
understanding
relationship
between
will
contribute
to
development
new
strategies
for
cancer
therapy.
In
this
review,
we
first
introduced
overall
stiffness,
analyzed
changes
mediated
tumor
progression,
finally
summarized
effects
targeting
prognosis
provide
insight
into
field.
