What is cancer metabolism?

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1670 - 1688

Published: Feb. 28, 2023

Language: Английский

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Embracing cancer complexity: Hallmarks of systemic disease

Cell, Journal Year: 2024, Volume and Issue: 187(7), P. 1589 - 1616

Published: March 1, 2024

Language: Английский

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Tumor biomarkers for diagnosis, prognosis and targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 20, 2024

Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.

Language: Английский

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Emerging therapies in cancer metabolism

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(8), P. 1283 - 1303

Published: Aug. 1, 2023

Language: Английский

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Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

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Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 101478 - 101478

Published: April 1, 2024

Immunotherapy has emerged as a robust approach against cancer, yet its efficacy varied among individuals, accompanied by the occurrence of immune-related adverse events. As result, immunotherapy is far from satisfactory, and enormous efforts have been invested to develop strategies improve patient outcomes. The gut microbiome now well acknowledged for critical role in immunotherapy, with better understanding on host-microbes interaction context cancer treatment. Also, an increasing number trials conducted evaluate potential feasibility microbiome-targeting approaches enhance treatment patients. Here, metabolites (e.g., short-chain fatty acids, tryptophan metabolites) underlying mechanisms are explored. application that aim fecal microbiota transplantation, probiotics, dietary intervention) also elaborated, further discussion current challenges suggestions future research.

Language: Английский

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1371 - 1393.e7

Published: May 7, 2024

The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well ameliorates established fibrosis without affecting total calorie intake. Furthermore, the blunted NASH-HCC when applied therapeutically. timing, length, number cycles type diet were critical parameters determining benefits fasting. Combined proteome, transcriptome, metabolome analyses peroxisome-proliferator-activated receptor alpha (PPARα) glucocorticoid-signaling-induced PCK1 act co-operatively hepatic executors response. In line with this, PPARα targets reduced human NASH. Notably, only initiated during active phase mice robustly induced glucocorticoid signaling free-fatty-acid-induced signaling. However, hepatocyte-specific deletion partially abrogated contrast, combined knockdown Ppara Pck1 vivo abolished beneficial outcomes against inflammation fibrosis. Moreover, overexpression alone or together lowered triglycerides steatosis. Our data support notion is a promising intervention subsequent liver cancer.

Language: Английский

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Emerging targets in lipid metabolism for cancer therapy

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(6), P. 537 - 551

Published: May 17, 2024

Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is hallmark cancer cells. Although alterations in have been appreciated over 20 years, there are no FDA-approved treatments that target lipid-related pathways. Recent advances pertaining to cell fatty acid synthesis (FAS), desaturation, uptake, microenvironmental dietary lipids, tumor-infiltrating immune illuminated promising clinical applications targeting metabolism. This review highlights emerging targets tumor may soon impact treatment.

Language: Английский

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Fasting: From Physiology to Pathology

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

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Dietary interventions and precision nutrition in cancer therapy

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 489 - 511

Published: May 30, 2023

Language: Английский

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