The cancer-immunity cycle: Indication, genotype, and immunotype

Immunity, Год журнала: 2023, Номер 56(10), С. 2188 - 2205

Опубликована: Окт. 1, 2023

The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.

Язык: Английский

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CD8+ T cells in the cancer-immunity cycle

Immunity, Год журнала: 2023, Номер 56(10), С. 2231 - 2253

Опубликована: Окт. 1, 2023

Язык: Английский

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Roles of macrophages in tumor development: a spatiotemporal perspective

Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(9), С. 983 - 992

Опубликована: Июль 10, 2023

Abstract Macrophages are critical regulators of tissue homeostasis but also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support development. While we know that TAMs dominant immune cells TME, their vast heterogeneity associated functions only just being unraveled. this review, outline various known TAM populations found thus far delineate specialized roles with main stages cancer progression. We discuss how may prime premetastatic niche enable growth a metastasis then subsequent metastasis-associated can secondary growth. Finally, speculate on challenges remain be overcome research.

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

Cancer Cell, Год журнала: 2023, Номер 41(11), С. 1927 - 1944.e9

Опубликована: Сен. 21, 2023

Язык: Английский

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The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics

Cancer Discovery, Год журнала: 2024, Номер 14(8), С. 1375 - 1388

Опубликована: Авг. 2, 2024

Abstract The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors known to support tumor progression and metastasis. interplay between the ECM cancer therapeutics opens up new avenues in understanding biology. While protect from anticancer agents by serving as a biomechanical barrier, emerging studies show that various therapies induce remodeling, resulting therapy resistance progression. This review discusses critical issues this field including how influences treatment outcome, affect challenges associated with targeting ECM. Significance: intricate relationship reveals novel insights into biology its effective treatment. may anti-cancer agents, recent research highlights paradoxical role therapy-induced remodeling promoting explores key aspects therapeutics.

Язык: Английский

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The role of tumor-associated macrophages in tumor immune evasion

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(5)

Опубликована: Май 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Язык: Английский

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Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

Cancer Cell, Год журнала: 2024, Номер 42(5), С. 815 - 832.e12

Опубликована: Апрель 18, 2024

Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes endothelial adherens junctions activating adrenomedullin paracrine signaling, thereby stimulating hyperpermeable neovasculature hampers drug delivery in glioblastoma xenografts. Accordingly, genetic ablation pharmacological blockade produced restores vascular integrity, improves intratumoral concentration anti-tumor agent dabrafenib, achieves combinatorial therapeutic benefits. Increased proportion expression predictive tumor vessel hyperpermeability worse prognosis glioblastoma. Our findings highlight diversity spatial niche-steered reprogramming indicate potential therapeutics targeting normalize vasculature.

Язык: Английский

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Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies

Trends in Immunology, Год журнала: 2023, Номер 44(12), С. 971 - 985

Опубликована: Ноя. 22, 2023

Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting macrophages has historically focused on inhibiting their recruitment or reprogramming phenotype from protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) spatial transcriptomics improved our understanding ontogeny, phenotype, functional plasticity macrophages. Overlaying wealth current information regarding macrophage molecular subtypes functions also identified novel therapeutic vulnerabilities might drive better control tumor-associated (TAMs). Here, we discuss profiling provide update macrophage-targeted therapies in development.

Язык: Английский

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PD-L1-expressing tumor-associated macrophages are immunostimulatory and associate with good clinical outcome in human breast cancer

Cell Reports Medicine, Год журнала: 2024, Номер 5(2), С. 101420 - 101420

Опубликована: Фев. 1, 2024

Tumor-associated macrophages (TAMs) are the predominant cells that express programmed cell death ligand 1 (PD-L1) within human tumors in addition to cancer cells, and PD-L1

Язык: Английский

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