Advanced Materials,
Год журнала:
2023,
Номер
35(25)
Опубликована: Янв. 12, 2023
Abstract
Emerging
piezocatalysts
have
demonstrated
their
remarkable
application
potential
in
diverse
medical
fields.
In
addition
to
ultrahigh
catalytic
activities,
inherent
and
unique
charge‐carrier‐releasing
properties
can
be
used
initiate
various
redox
reactions,
displaying
bright
prospects
for
future
applications.
Triggered
by
mechanical
energy,
piezocatalytic
materials
release
electrons/holes,
catalyze
reactions
of
substrates,
or
intervene
biological
processes
promote
the
production
effector
molecules
purposes,
such
as
decontamination,
sterilization,
therapy.
Such
a
piezocatalysis
is
termed
medicine
(PCM)
herein.
To
pioneer
novel
technologies,
especially
therapeutic
modalities,
this
review
provides
an
overview
state‐of‐the‐art
research
progress
medicine.
First,
principle
preparation
methodologies
piezoelectric
are
introduced.
Then,
comprehensive
summary
applications
tumor
treatment,
antisepsis,
organic
degradation,
tissue
repair
regeneration,
biosensing
provided.
Finally,
main
challenges
perspectives
discussed
proposed,
expecting
fuel
development
emerging
scientific
discipline.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Diabetic
foot
ulcers
(DFU),
one
of
the
most
serious
complications
diabetes,
are
essentially
chronic,
nonhealing
wounds
caused
by
diabetic
neuropathy,
vascular
disease,
and
bacterial
infection.
Given
its
pathogenesis,
DFU
microenvironment
is
rather
complicated
characterized
hyperglycemia,
ischemia,
hypoxia,
hyperinflammation,
persistent
However,
current
clinical
therapies
for
dissatisfactory,
which
drives
researchers
to
turn
attention
advanced
nanotechnology
address
therapeutic
bottlenecks.
In
last
decade,
a
large
number
multifunctional
nanosystems
based
on
have
been
developed
with
positive
effects
in
therapy,
forming
novel
concept
"DFU
nanomedicine".
systematic
overview
nanomedicine
still
unavailable
literature.
This
review
summarizes
microenvironmental
characteristics
DFU,
presents
main
progress
wound
healing,
summaries
state-of-the-art
strategies
DFU.
Furthermore,
challenges
future
perspectives
this
field
discussed
prospected,
aiming
fuel
foster
development
nanomedicines
successfully.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
ACS Nano,
Год журнала:
2022,
Номер
16(6), С. 9479 - 9497
Опубликована: Июнь 17, 2022
Oral
infectious
diseases
and
tooth
staining,
the
main
challenges
of
dental
healthcare,
are
inextricably
linked
to
microbial
colonization
formation
pathogenic
biofilms.
However,
dentistry
has
so
far
still
lacked
simple,
safe,
universal
prophylactic
options
therapy.
Here,
we
report
copper-doped
carbon
dots
(Cu-CDs)
that
display
enhanced
catalytic
(catalase-like,
peroxidase-like)
activity
in
oral
environment
for
inhibiting
initial
bacteria
(Streptococcus
mutans)
adhesion
subsequent
biofilm
eradication
without
impacting
surrounding
tissues
via
oxygen
(O2)
reactive
species
(ROS)
generation.
Especially,
Cu-CDs
exhibit
strong
affinity
lipopolysaccharides
(LPS)
peptidoglycans
(PGN),
thus
conferring
them
with
excellent
antibacterial
ability
against
Gram-positive
(Staphylococcus
aureus)
Gram-negative
(Escherichia
coli),
such
they
can
prevent
wound
purulent
infection
promoting
rapid
healing.
Additionally,
Cu-CDs/H2O2
system
shows
a
better
performance
whitening,
compared
results
obtained
other
alternatives,
e.g.,
CDs
clinically
used
H2O2,
particularly
its
negligible
enamel
dentin
destruction.
It
is
anticipated
biocompatible
presented
this
work
promising
nano-mouthwash
eliminating
biofilms,
prompting
healing
as
well
highlighting
their
significance
health
management.
ACS Nano,
Год журнала:
2022,
Номер
16(6), С. 9130 - 9141
Опубликована: Май 18, 2022
Photodynamic
therapy
as
an
emerging
phototheranostic
approach
holds
great
potential
for
antibacterial
treatment,
but
is
limited
by
compromised
reactive
oxygen
species
(ROS)
generation
in
aggregate
and
hypoxic
microenvironment.
Herein,
we
report
a
molecular
cationization
to
boost
the
ROS,
especially
type
I
ROS
of
aggregation-induced
emission
(AIE)
photosensitizers
photodynamic
treatment
drug-resistant
bacteria.
Such
reinforces
electron-accepting
ability
cationic
moiety,
promotes
intersystem
crossing
(ISC),
increases
electron
separation
transfer
processes.
The
resultant
CTBZPyI
exhibits
largely
enhanced
with
predominant
hydroxyl
radical
over
its
neutral
counterpart
aggregate.
Moreover,
also
confers
bacterial
binding
moderate
inactivation
dark.
Further
light
irradiation
leads
superb
performance,
which
healing
process
MRSA-infected
wound.
strategy
expected
be
general
design
highly
effective
infection
treatment.
