Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Infection microenvironment-related antibacterial nanotherapeutic strategies

Biomaterials, Journal Year: 2021, Volume and Issue: 280, P. 121249 - 121249

Published: Nov. 11, 2021

Language: Английский

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Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9130 - 9141

Published: May 18, 2022

Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in aggregate and hypoxic microenvironment. Herein, we report a molecular cationization to boost the ROS, especially type I ROS of aggregation-induced emission (AIE) photosensitizers photodynamic treatment drug-resistant bacteria. Such reinforces electron-accepting ability cationic moiety, promotes intersystem crossing (ISC), increases electron separation transfer processes. The resultant CTBZPyI exhibits largely enhanced with predominant hydroxyl radical over its neutral counterpart aggregate. Moreover, also confers bacterial binding moderate inactivation dark. Further light irradiation leads superb performance, which healing process MRSA-infected wound. strategy expected be general design highly effective infection treatment.

Language: Английский

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Copper Doped Carbon Dots for Addressing Bacterial Biofilm Formation, Wound Infection, and Tooth Staining

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9479 - 9497

Published: June 17, 2022

Oral infectious diseases and tooth staining, the main challenges of dental healthcare, are inextricably linked to microbial colonization formation pathogenic biofilms. However, dentistry has so far still lacked simple, safe, universal prophylactic options therapy. Here, we report copper-doped carbon dots (Cu-CDs) that display enhanced catalytic (catalase-like, peroxidase-like) activity in oral environment for inhibiting initial bacteria (Streptococcus mutans) adhesion subsequent biofilm eradication without impacting surrounding tissues via oxygen (O2) reactive species (ROS) generation. Especially, Cu-CDs exhibit strong affinity lipopolysaccharides (LPS) peptidoglycans (PGN), thus conferring them with excellent antibacterial ability against Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli), such they can prevent wound purulent infection promoting rapid healing. Additionally, Cu-CDs/H2O2 system shows a better performance whitening, compared results obtained other alternatives, e.g., CDs clinically used H2O2, particularly its negligible enamel dentin destruction. It is anticipated biocompatible presented this work promising nano-mouthwash eliminating biofilms, prompting healing as well highlighting their significance health management.

Language: Английский

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Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Feb. 12, 2023

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant

Language: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

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Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Science China Chemistry, Journal Year: 2022, Volume and Issue: 66(1), P. 155 - 163

Published: Dec. 8, 2022

Language: Английский

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