Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Фев. 16, 2023
Biofilms
are
viscoelastic
materials
that
a
prominent
public
health
problem
and
cause
of
most
chronic
bacterial
infections,
in
large
part
due
to
their
resistance
clearance
by
the
immune
system.
Viscoelastic
combine
both
solid-like
fluid-like
mechanics,
properties
biofilms
an
emergent
property
intercellular
cohesion
characterizing
biofilm
state
(planktonic
bacteria
do
not
have
equivalent
property).
However,
how
mechanical
related
recalcitrant
disease
they
cause,
specifically
phagocytic
system,
remains
almost
entirely
unstudied.
We
believe
this
is
important
gap
ripe
for
range
investigations.
Here
we
present
overview
what
known
about
infections
interactions
with
mechanics
potential
relationship
phagocytosis,
give
illustrative
example
one
biofilm-pathogen
(Pseudomonas
aeruginosa)
which
most-studied
context.
hope
inspire
investment
growth
relatively-untapped
field
research,
has
reveal
as
targets
therapeutics
meant
enhance
efficacy
Biology,
Год журнала:
2024,
Номер
13(2), С. 95 - 95
Опубликована: Фев. 2, 2024
Soil-beneficial
microbes
in
the
rhizosphere
play
important
roles
improving
plant
growth
and
health.
Root
exudates
key
plant–microbe
interactions
rhizobacterial
colonization.
This
review
describes
factors
influencing
dynamic
between
root
soil
microbiome
rhizosphere,
including
genotype,
development,
environmental
abiotic
biotic
factors.
We
also
discuss
of
specific
metabolic
mechanisms,
regulators,
signals
beneficial
bacteria
terms
colonization
ability.
highlight
latest
research
progress
on
regulating
Organic
acids,
amino
sugars,
sugar
alcohols,
flavonoids,
phenolic
compounds,
volatiles,
other
secondary
metabolites
are
discussed
detail.
Finally,
we
propose
future
objectives
that
will
help
us
better
understand
role
by
rhizobacteria
promote
sustainable
development
agriculture
forestry.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 25, 2024
The
compact
three-dimensional
(3D)
structure
of
extracellular
polymeric
substances
(EPS)
within
biofilms
significantly
hinders
the
penetration
antimicrobial
agents,
making
biofilm
eradication
challenging
and
resulting
in
persistent
biofilm-associated
infections.
To
address
this
challenge,
a
solution
is
proposed:
probiotic
bio-heterojunction
(P-bioHJ)
combining
Lactobacillus
rhamnosus
with
MXene
(Ti
Abstract
Biofilm‐associated
infections
are
one
of
the
most
challenging
healthcare
threats
for
humans,
accounting
80%
bacterial
infections,
leading
to
persistent
and
chronic
infections.
The
conventional
antibiotics
still
face
their
dilemma
poor
therapeutic
effects
due
high
tolerance
resistance
led
by
biofilm
barriers.
Nanotechnology‐based
antimicrobials,
nanoparticles
(NPs),
paid
attention
extensively
considered
as
promising
alternative.
This
review
focuses
on
whole
journey
NPs
against
biofilm‐associated
clarify
it
clearly,
is
divided
into
four
processes
in
sequence
1)
Targeting
biofilms,
2)
Penetrating
barrier,
3)
Attaching
cells,
4)
Translocating
through
cell
envelope.
Through
outlining
compositions
properties
biofilms
bacteria
recent
advances
present
strategies
each
process
comprehensively
discussed
combat
well
combined
these
with
drug
resistance,
aiming
guide
rational
design
facilitate
wide
application
Water Research,
Год журнала:
2022,
Номер
229, С. 119485 - 119485
Опубликована: Дек. 12, 2022
A
good
floc
formation
of
activated
sludge
(AS)
is
crucial
for
solid-liquid
separation
and
production
clean
effluent
during
wastewater
treatment.
Floc
partly
controlled
by
self-produced
extracellular
polymeric
substances
(EPS)
such
as
exopolysaccharides,
proteins,
nucleic
acids.
Little
known
about
the
composition,
structure,
function
EPS
in
AS
which
bacteria
produce
them.
To
address
this
knowledge
gap
we
took
advantage
1083
high-quality
metagenome-assembled
genomes
(MAGs)
obtained
from
23
Danish
treatment
plants.
We
investigated
genomic
potential
exopolysaccharide
biosynthesis
bacterial
species
typical
systems
based
on
genome
mining
gene
synteny
analyses.
Putative
clusters
associated
with
alginate,
cellulose,
curdlan,
diutan,
hyaluronic
acids,
Pel,
poly-β-1,6-N-acetyl-d-glucosamine
(PNAG),
Psl,
S88
capsular
polysaccharide,
salecan,
succinoglycan,
xanthan
were
identified
linked
to
individual
MAGs,
providing
a
comprehensive
overview
genome-resolved
these
exopolysaccharides
bacteria.
The
approach
results
provide
starting
point
more
understanding
composition
systems,
may
facilitate
refined
regulation
process
improved
stability.
Advanced Materials Interfaces,
Год журнала:
2023,
Номер
10(24)
Опубликована: Июль 20, 2023
Abstract
The
recent
COVID‐19
pandemic
and
the
accelerating
rise
of
deaths
associated
with
antibiotic‐resistant
bacterial
strains
have
highlighted
global
health
economic
threats
caused
by
super
spreading
pathogens.
A
major
route
transmission
for
pathogens
is
via
surfaces
contaminated
touch
or
droplets
generated
sneezing
coughing.
Current
surface
disinfection
strategies
are
having
diminishing
efficacy,
due
to
increasing
number
superbugs
short‐lasting
effect
disinfectants
resulting
in
recontamination.
New
inhibiting
surface‐mediated
pathogen
focus
significant
multi‐disciplinary
efforts.
Among
those,
development
superhydrophobic
(SHS)
increasingly
regarded
as
a
powerful
alternative,
additive,
antimicrobial
strategies.
SHS
provide
neutral/inert
interface
that
can
prevent
viral
colonization.
Here,
use
such
water‐repellent
coatings
critically
reviewed
impede
pathogens,
addressing
challenges
future
directions
their
translation
into
real‐world
settings.
