Bacteriochlorins and their metal complexes as NIR-absorbing photosensitizers: properties, mechanisms, and applications

Coordination Chemistry Reviews, Год журнала: 2020, Номер 416, С. 213340 - 213340

Опубликована: Май 5, 2020

Bacterichlorins possess a characteristic intense electronic absorption in the near-infrared part of electromagnetic radiation (NIR) from 700 nm up to 900 nm, where endogenous chromophores do not absorb and which allows deep penetration through tissues. Although naturally-occurring metal complexes derived bacteriochlorophylls are unstable their use is limited, it currently possible obtain large-scale libraries photostable synthetic compounds belonging bacteriochlorin family. This review presents an up-to-date overview most significant studies on synthesis, spectroscopic, photochemical, electrochemical characteristics as well various potential applications bacteriochlorins complexes. Particular emphasis has been given possibilities medicine, especially photodynamic therapy cancer (PDT), photodiagnosis (PD), inactivation (PDI) bacteria, viruses, fungi. The combination (metallo)bacteriochlorins with polymeric micelles, lipoproteins, nanoparticles, metal-organic frameworks order increase efficacy also discussed. Other discussed this paper include light-harvesting antennas, optical sensors, photocatalysts, dye-sensitized solar cells for efficient energy conversion.

Язык: Английский

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Pyclen-Based Ln(III) Complexes as Highly Luminescent Bioprobes for In Vitro and In Vivo One- and Two-Photon Bioimaging Applications

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(22), С. 10184 - 10197

Опубликована: Май 5, 2020

In addition to the already described ligand L4a, two pyclen-based lanthanide chelators, L4b and L4c, bearing specific picolinate two-photon antennas (tailor-made for each targeted metal) one acetate arm arranged in a dissymmetrical manner, have been synthesized, form complete family of luminescent bioprobes: [EuL4a], [SmL4a], [YbL4b], [TbL4c], [DyL4c]. Additionally, symmetrically regioisomer L4a′ was also synthesized as well its [EuL4a′] complex highlight astonishing positive impact N-distribution functional chelating arms. The investigation clearly shows high performance bioprobe, which, depending on complexed lanthanide, could be used various applications. Each presents brightness, quantum yields, lifetimes. Staining complexes into living human breast cancer cells observed. addition, vivo microscopy performed first time zebrafish model with [EuL4a]. No apparent toxicity detected growth zebrafish, images quality were obtained.

Язык: Английский

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Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications

Chemical Society Reviews, Год журнала: 2021, Номер 50(21), С. 12189 - 12257

Опубликована: Янв. 1, 2021

Tetrapyrrole derivatives such as porphyrins, phthalocyanines, naphthalocyanines, and porpholactones, are highly stable macrocyclic compounds playing crucial roles in biophotonics biomedicine presently at the centre of stunning new applications.

Язык: Английский

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Recent advances in design of lanthanide-containing NIR-II luminescent nanoprobes

iScience, Год журнала: 2021, Номер 24(2), С. 102062 - 102062

Опубликована: Янв. 20, 2021

Luminescent biosensing in the second near-infrared window (NIR-II, 1000–1700 nm) region, which has weak tissue scattering and low autofluorescence, draws extensive attention owing to its deep penetration, good spatial resolution high signal-to-background ratio. As a new generation of NIR-II probes, lanthanide (Ln3+)-containing nanoprobes exhibit several superior properties. With rapid development Ln3+-containing nanoprobes, many significant advances have been accomplished their optical properties tuning surface functional modification for further bioapplications. Rather than being exhaustive, this review aims survey recent design strategies inorganic luminescent by highlighting performance optimization approaches. Moreover, challenges opportunities kind novel are envisioned.

Язык: Английский

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Metal Modulation: An Easy-to-Implement Tactic for Tuning Lanthanide Phototheranostics

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(19), С. 7541 - 7552

Опубликована: Май 11, 2021

Phototheranostics constitute an emerging cancer treatment wherein the core diagnostic and therapeutic functions are integrated into a single photosensitizer (PS). Achieving full potential of this modality requires being able to tune photosensitizing properties PS in question. Structural modification organic framework represents time-honored strategy for tuning photophysical features given system. Here we report easy-to-implement metal selection approach that allows fine-tuning excited-state energy dissipation phototheranostics as exemplified by set lanthanide (Ln = Gd, Yb, Er) carbazole-containing porphyrinoid complexes. Femto- nanosecond time-resolved spectroscopic studies, conjunction with density functional theory calculations, revealed pathways PSs highly dependent on gap between lowest triplet excited state ligand states coordinated Ln ions. The Yb complex displayed balance deactivation mechanisms made it attractive combined photoacoustic imaging photothermal/photodynamic therapy agent. It was encapsulated mesoporous silica nanoparticles (MSN) provide biocompatible construct, YbL@MSN, which displays high photothermal conversion efficiency (η 45%) decent singlet oxygen quantum yield (ΦΔ 31%). Mouse model studies YbL@MSN both synergistic photothermal- photodynamic-therapy-based tumor reduction vivo. Our results lead us suggest promising phototheranostics.

Язык: Английский

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Lanthanide porphyrinoids as molecular theranostics

Chemical Society Reviews, Год журнала: 2022, Номер 51(14), С. 6177 - 6209

Опубликована: Янв. 1, 2022

This Review summarises the history and ‘state-of-the-art’ development of lanthanide (Ln) porphyrinoids as theranostic agents. Applications such near-infrared (NIR) fluorescence imaging (FL), magnetic resonance (MRI), radiotherapy, chemotherapy phototheranostics will be discussed.

Язык: Английский

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Rare-earth based tetrapyrrolic sandwiches: chemistry, materials and applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(22), С. 9262 - 9339

Опубликована: Янв. 1, 2022

This review summarises advances in chemistry of tetrapyrrole sandwiches with rare earth elements and highlights the current state their use single-molecule magnetism, organic field-effect transistors, conducting materials nonlinear optics.

Язык: Английский

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Deep-red/NIR emitting coumarin derivatives - Synthesis, photophysical properties, and biological applications

Dyes and Pigments, Год журнала: 2022, Номер 202, С. 110306 - 110306

Опубликована: Апрель 9, 2022

Язык: Английский

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Functionalization of luminescent lanthanide complexes for biomedical applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 474, С. 214866 - 214866

Опубликована: Окт. 8, 2022

Язык: Английский

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Multifunctionality of luminescent molecular nanomagnets based on lanthanide complexes

Chemical Communications, Год журнала: 2023, Номер 59(40), С. 5961 - 5986

Опубликована: Янв. 1, 2023

Multifunctional materials, which exhibit diverse physical properties, are candidates for the new generation of smart devices that realize many tasks simultaneously. Particular attention is given to single-phase multifunctional materials offer effects induced by coupling between introduced properties. Complexes lanthanide(3+) ions an attractive source multifunctionality since they combine luminescent functionalities related their f-f or d-f electronic transitions with magnetic anisotropy originates from spin-orbit and crystal-field effects. The resulting single-molecule magnets (SMMs) link area functional luminophores, applicable in light-emitting diodes sensing, field molecular magnets, high-density data storage, additional advantages, e.g., fruitful magneto-optical correlations switching emission a field. It was recently shown lanthanide SMMs can provide richly expanded towards sensitivity solvent exchange, temperature, light, as well electrical such super-ionic conductivity ferroelectricity, non-centrosymmetricity- chirality-related effects, second-harmonic circularly polarized luminescence. Here, we discuss pioneering reports on use SMMs, emphasis our contribution relying functionalization 4f metal complexes through insertion into heterometallic coordination compounds.

Язык: Английский

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