A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(14)

Опубликована: Фев. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Язык: Английский

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Fluorescent probes for the detection of disease-associated biomarkers

Science Bulletin, Год журнала: 2022, Номер 67(8), С. 853 - 878

Опубликована: Янв. 17, 2022

Язык: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(27)

Опубликована: Март 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Язык: Английский

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Recent advances in the development of near-infrared organic photothermal agents

Chemical Engineering Journal, Год журнала: 2021, Номер 417, С. 128844 - 128844

Опубликована: Фев. 7, 2021

Язык: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Год журнала: 2022, Номер 35(18)

Опубликована: Ноя. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Язык: Английский

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Photothermal antibacterial materials to promote wound healing

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 180 - 200

Опубликована: Сен. 27, 2023

Язык: Английский

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Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(36)

Опубликована: Июль 23, 2021

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-molecule immunomodulators lead the off-target adverse effects insufficient therapeutic outcomes. Herein a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of reported. ASPA backbone obtained by conjugating vipadenant, an antagonist adenosine A2A receptor, onto NIR-II light-absorbing polymer via azo-based thermolabile linker. Under deep-penetrating photoirradiation, induces tumor thermal ablation subsequently immunogenic cell death, triggers cleavage linker, releases block adenosinergic pathway. Such remotely controlled regulation potentiates cytotoxic T functions while suppresses regulatory activities, leading efficient primary inhibition, pulmonary metastasis prevention, long-term immunological memory. Thereby, this work provides generic approach precise spatiotemporal immunometabolism.

Язык: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215426 - 215426

Опубликована: Сен. 6, 2023

Язык: Английский

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Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Aggregate, Год журнала: 2021, Номер 2(4)

Опубликована: Фев. 23, 2021

Abstract Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis treatment of contemporary diseases, organic dyes play vital role. For example, chemical modification endowed with powerful reactive oxygen species or heat generation ability, favoring photodynamic therapy photoacoustic (PA) imaging guided photothermal (PTT) serious diseases. Therefore, photophysical properties manipulation has become focus in current dye chemistry research. The development aggregate science made great effort to solve this problem. In recent years, large number studies have focused on molecular aggregation behavior its effect performance. most famous example is discovery aggregation‐induced emission (AIE) phenomenon. Based AIE theory, more theories revealing relationship between were proposed elucidated. property changes caused by unique discipline, guiding material science. With help self‐assembly, controllable can be realized, stable nano‐theranostic reagents obtained. Furthermore, constructing assemblies various will greatly reduce cost theranostic reagents, thus, expanding biomedical applications dyes. review focuses characteristic their biological including, fluorescence/phosphorescence/PA as well PTT. This guidance design dyes, methods, construction multifunctional phototheranostic reagents.

Язык: Английский

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Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

Bioactive Materials, Год журнала: 2022, Номер 17, С. 49 - 70

Опубликована: Фев. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Язык: Английский

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