Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июнь 26, 2023
Abstract
Malignant
bone
tumors
result
in
high
rates
of
disability
and
death
are
difficult
to
treat
terms
killing
repairing
defects.
Compared
with
other
hyperthermia
strategies,
magnetic
has
become
an
effective
therapy
for
treating
malignant
due
its
lack
depth
limitations.
However,
tumor
cells
express
heat
shock
protein
(HSP)
resist
hyperthermia,
which
reduces
curative
effect.
Competitive
ATP
consumption
can
reduce
HSP
production;
fortunately,
the
basic
principle
starvation
by
glucose
oxidase
(GOx)
is
consuming
control
production,
thereby
restricting
generation.
We
developed
a
triple-functional
gel
(Fe
3
O
4
/GOx/MgCO
@PLGA)
as
repair
hydrogels
(MBRs)
liquid‒solid
phase
transition
capability
drive
magneto-thermal
effects
simultaneously
trigger
GOx
release
inhibit
reducing
expression
achieving
synergistic
osteosarcoma
treatment.
Moreover,
improves
effect
on
hypoxic
microenvironment
achieves
reciprocal
strengthening
therapeutic
further
demonstrated
that
situ
MBRs
injection
effectively
suppressed
growth
143B
tumor-bearing
mice
in-situ
model
rabbit
tibial
plateau.
More
importantly,
our
study
also
showed
liquid
could
match
defects
accelerate
their
reconstruction
via
magnesium
ion
enhanced
osteogenic
differentiation
augment
regeneration
caused
tumors,
generates
fresh
insight
into
treatment
acceleration
defect
repair.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 7326 - 7378
Опубликована: Март 13, 2023
Cancer
thermal
therapy,
also
known
as
hyperthermia
has
long
been
exploited
to
eradicate
mass
lesions
that
are
now
defined
cancer.
With
the
development
of
corresponding
technologies
and
equipment,
local
therapies
such
radiofrequency
ablation,
microwave
high-intensity
focused
ultrasound,
have
validated
effectively
ablate
tumors
in
modern
clinical
practice.
However,
they
still
face
many
shortcomings,
including
nonspecific
damages
adjacent
normal
tissues
incomplete
ablation
particularly
for
large
tumors,
restricting
their
wide
usage.
Attributed
versatile
physiochemical
properties,
biomaterials
specially
designed
potentiate
treatments
according
unique
working
principles.
Meanwhile,
biomaterial-based
delivery
systems
able
bridge
with
other
types
treatment
strategies
chemotherapy,
radiotherapy
immunotherapy.
Therefore,
this
review,
we
discuss
recent
progress
functional
reinforce
by
functioning
sensitizers
endow
more
efficient
tumor-localized
and/or
vehicles
synergize
therapeutic
modalities
combined
cancer
treatments.
Thereafter,
provide
a
critical
perspective
on
further
biomaterial-assisted
toward
applications.
Nanomaterials,
Год журнала:
2022,
Номер
12(16), С. 2826 - 2826
Опубликована: Авг. 17, 2022
Cancer
theranostics
is
the
combination
of
diagnosis
and
therapeutic
approaches
for
cancer,
which
essential
in
personalized
cancer
treatment.
The
aims
application
nanoparticles
detection
therapy
are
to
reduce
delays
treatment
hence
improve
patient
care.
Recently,
it
has
been
found
that
functionalization
can
efficiency,
performance,
specificity
sensitivity
structure,
increase
stability
body
acidic
environment.
Moreover,
functionalized
have
possess
a
remarkable
theranostic
ability
revolutionized
Each
modality,
such
as
MRI-guided
gene
therapy,
thermal
magnetic
hyperthermia
treatment,
chemotherapy,
immunotherapy,
photothermal
photodynamic
its
strengths
weaknesses,
combining
modalities
allows
better
platform
improved
control.
This
why
investigated
thoroughly
recent
years
enabled
by
nanoparticles.
In
this
topical
review,
we
look
at
advances
using
Through
understanding
updating
development
nanoparticle-based
theranostics,
find
out
future
challenges
perspectives
novel
type
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Materials Advances,
Год журнала:
2022,
Номер
3(20), С. 7425 - 7444
Опубликована: Янв. 1, 2022
Magnetic
nanoparticles
(MNPs)
show
tremendous
possibilities
in
the
field
of
biomedicine,
especially
as
therapeutic
agents
for
use
over
a
prolonged
duration.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 868 - 868
Опубликована: Март 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
