Опубликована: Янв. 1, 2024
Язык: Английский
Clinical Nutrition, Год журнала: 2024, Номер 43(3), С. 869 - 880
Опубликована: Фев. 13, 2024
Background & Aims Butyrate (one of the short-chain fatty acids), a major byproduct fermentation non-digestible carbohydrates (e.g. fiber), is supposed to have anti-obesity and anti-inflammatory properties. However, butyrate's potential mechanism in preventing obesity efficient form administration remain be clarified. Methods Hence, we studied effect oral supplementation with 5% (w/w) sodium butyrate 4% β-glucan (fiber) young male mice (C57BL/6J) high-fat diet-induced (HFD: 60 kcal% fat + 1% cholesterol). 6 weeks old were fed diets based on HFD or control (AIN) diet with/without supplements for 4 weeks. The unique, interdisciplinary approach combining several Raman-based techniques (including Raman microscopy fiber optic spectroscopy) next-generation sequencing was used ex vivo analyze various depots adipose tissue (white, brown, perivascular) gut microbiome, respectively. Results findings demonstrate that more effectively prevent pathological increase body weight caused by elevated saturated acids influx linked comparison β-glucan, thereby entirely inhibiting obesity. Moreover, significantly affects white (WAT) reducing epididymal WAT mass without supplements, decreasing lipid saturation thoracic aortic perivascular tissue. Contrarily, changes composition diversity reversing HF diet, but shows no therefore gain inhibition not as effective butyrate. Conclusions Here, has been proven an through two different targets. Administration-dependent effects imposes (oral administration) microbiome (fiber-derived) make it promising candidate personalized treatment
Язык: Английский
Процитировано
7
Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(31), С. 11543 - 11555
Опубликована: Июль 27, 2023
Diabetes mellitus (DM) is a chronic metabolic disease caused by complex interaction of genetic and environmental factors characterized persistent hyperglycemia. Long-term hyperglycemia can cause macrovascular microvascular damage, compromise the heart, brain, kidney, peripheral nerves, eyes other organs, leading to serious complications. Genistein, phytoestrogen derived from soybean, known for its various biological activities therapeutic properties. Recent studies found that genistein not only has hypoglycemic activity but also decrease insulin resistance. In addition, particular in prevention treatment diabetic complications, such as nephropathy, cardiovascular disease, osteoarthrosis, encephalopathy retinopathy. Therefore, purpose this review summarize latest medical research progress DM related complications highlights potential molecular mechanisms targets. Meanwhile, evidence provided development application drug or functional food diabetes
Язык: Английский
Процитировано
15
Food & Function, Год журнала: 2023, Номер 14(10), С. 4662 - 4680
Опубликована: Янв. 1, 2023
Obesity is a serious health problem, and it important to discover natural active ingredients for alleviating it. In this study, we investigated the effect of phenolamide extract (PAE) from apricot bee pollen on obese mice fed high-fat diet (HFD). The main compounds in PAE were identified by HPLC-ESI-QTOF-MS/MS, HFD-fed treated with 12 weeks. results demonstrated that content phenolamides was 87.75 ± 5.37%, tri-p-coumaroyl spermidine as dominant compound. intervention effectively reduced weight gain lipid accumulation liver epididymal fat, increased glucose tolerance, insulin resistance improved metabolism. terms gut microbiota, could reverse increase Firmicutes/Bacteroidetes ratio mice. addition, beneficial bacteria such Muribaculaceae Parabacteroides, reduce harmful Peptostreptococcaceae Romboutsia. Metabolomic analysis revealed regulate levels metabolites, including bile acids, phosphatidyl choline (PC), lysophosphatidylcholine (lysoPC), lysophosphatidylethanolamine (lysoPE) tyrosine. This first study finding can glucolipid metabolism modulate microbiota metabolites HFD-induced mice, indicate be used functional dietary supplement alleviate obesity.
Язык: Английский
Процитировано
14
European Journal of Nutrition, Год журнала: 2024, Номер 63(5), С. 1877 - 1888
Опубликована: Апрель 9, 2024
Язык: Английский
Процитировано
5
Life, Год журнала: 2023, Номер 13(7), С. 1468 - 1468
Опубликована: Июнь 28, 2023
Recent research revealed that dietary genistein supplementation for breeder hens can improve the immune function of offspring chicks. However, it remains unknown whether this maternal effect could intestinal health offspring. This study was conducted to explore mechanism involved in on mucosa and microbial homeostasis chicken A total 120 Qiling were fed a basal diet, 20 mg/kg genistein-supplemented or 40 diet 4 weeks before collecting their eggs. After hatching, 180 male (60 chickens from each group) randomly selected divided into three groups: (1) (CON); (2) low-dose (LGE); (3) high-dose (HGE). At 17 d, 72 (48 CON 24 LGE) group challenged with LPS (LPS); LGE (LPS + LGE). The results showed increased birth weight serum level protein (TP), followed by improved villus morphology. Continuously, body chicks lasted until 21 d. Additionally, observed exhibited protective effects against LPS-induced morphological damage mucosal barrier dysfunction upregulating expression tight junction proteins, specifically ZO-1, Claudin1, E-cadherin, Occludin, at Using 16S rRNA gene sequencing, we demonstrated has potential facilitate maturation newly hatched enhancing abundance Escherichia coli. effectively reduce Gammaproteobacteria, thus mitigating risk bacterial diversity impairment LPS. In light these findings, holds promise as strategy ameliorating modulating microbiome
Язык: Английский
Процитировано
10
Food Chemistry X, Год журнала: 2023, Номер 19, С. 100788 - 100788
Опубликована: Июль 12, 2023
This study aimed to compare the nutritive value and obesity prevention of ordinary Cordyceps militaris (CM) selenium-enriched CM (SeCM). The results indicated that Se enrichment significantly increased total carbohydrate soluble dietary fiber content, while protein insoluble content decreased. Although fat was not affected, medium long-chain fatty acids changed. Moreover, elevated secondary metabolites belonging terpenoids alkaloids, which are linked with enhanced biosynthesis metabolites. Both SeCM reduced body weight, adipose accumulation, impaired glucose tolerance, lipid levels in high-fat diet (HFD)-fed mice, there no significant difference between them. Network pharmacological analysis revealed prevented HFD-induced associated metabolic diseases multi-ingredients acting on multi-targets. Overall, improved without altering its role preventing obesity.
Язык: Английский
Процитировано
10
Applied Biochemistry and Biotechnology, Год журнала: 2024, Номер 196(10), С. 6690 - 6715
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
4
Current Research in Food Science, Год журнала: 2024, Номер 9, С. 100823 - 100823
Опубликована: Янв. 1, 2024
Matcha shows promise for diabetes, obesity, and gut microbiota disorders. Studies suggest a significant link between microbiota, metabolites, obesity. Thus, matcha may have positive impact on obesity by modulating metabolites. This study used 16S rDNA sequencing untargeted metabolomics to examine the cecal contents in mice. By correlation analysis, we explored potential mechanisms responsible effects of The results indicated that had mitigating effect detrimental impacts high-fat diet (HFD) multiple physiological indicators mice, including body weight, adipose tissue serum total cholesterol (TC), low-density lipoprotein (LDL) levels, as well glucose tolerance. Moreover, it was observed an structural composition Specifically, able reverse alterations abundance certain obesity-improving bacteria, such Alloprevotella, Ileibacterium, Rikenella, obesity-promoting bacteria Romboutsia, induced HFD. Furthermore, can influence levels formononetin, glutamic acid, pyroglutamic taurochenodeoxycholate, within gastrointestinal tract. Additionally, enhances caffeine metabolism HIF-1 signaling pathway KEGG pathway. analysis theobromine, 1,3,7-trimethyluric Vitamin C displayed negative with both phenotype known exacerbate while demonstrating correlations alleviated However, taurochenodeoxycholate opposite effect. In conclusion, metabolites be attributed its modulation Romboutsia tract, thereby potentially contributing amelioration
Язык: Английский
Процитировано
4
Pharmaceuticals, Год журнала: 2024, Номер 17(2), С. 236 - 236
Опубликована: Фев. 11, 2024
Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective Recognizing the increasing prevalence cardiovascular diseases (CVD), there is growing interest in understanding potential benefits associated these compounds. Gut microbiota may play key role mediating effects isoflavones on vascular endothelial functions, it directly implicated metabolism. The findings from randomized clinical trials indicate isoflavone supplementation putative biomarkers among healthy individuals, but not patients affected by cardiometabolic disorders. results might be explained enzymatic transformation to which subjected gut microbiota, suggesting diverse composition determine bioavailability Specifically, conversion equol—a microbiota-derived metabolite—seems differ between individuals. Further studies needed clarify intricate molecular mechanisms behind contrasting results.
Язык: Английский
Процитировано
3
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 435 - 445
Опубликована: Фев. 1, 2024
Background: Traditional observational studies have found a possible risk association of the gut microbiota for psoriasis. Meanwhile, psoriasis may also affect changes in microbiota. However, available evidence does not demonstrate reciprocal relationship between and This limits our understanding on role mechanisms Methods: To address this question we used Mendelian randomization, novel epidemiological approach, acquired largest current GWAS data from MiBioGen consortium as well FinnGen consortium, performed two-sample bidirectional MR analyses using multiple analysis approach. Finally, robustness results was assessed by sensitivity analysis. Results: Our indicate that five bacterial genera are causally related to is four genera. Conclusion: These suggest causal influence somewhat challenge inferences previous studies. We specific with effect were different those characterize studies, these psoriasis-characterizing inversely associated Keywords: psoriasis, relationship, microbiota, randomization
Язык: Английский
Процитировано
3