Immunology Letters, Год журнала: 2023, Номер 263, С. 70 - 77
Опубликована: Окт. 4, 2023
Язык: Английский
Journal of Functional Foods, Год журнала: 2024, Номер 119, С. 106337 - 106337
Опубликована: Июль 6, 2024
Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.
Язык: Английский
Процитировано
46
Virulence, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 27, 2024
Metabolic disease is a worldwide epidemic that has become public health problem. Gut microbiota considered to be one of the important factors maintain human by regulating host metabolism. As an abundant bacterium in gut,
Язык: Английский
Процитировано
16
Foods, Год журнала: 2023, Номер 12(13), С. 2485 - 2485
Опубликована: Июнь 26, 2023
A new next-generation probiotic,
Язык: Английский
Процитировано
23
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Июль 10, 2023
Arecoline is an alkaloid extracted from betel nut, which has various pharmacological effects. In the present study, we showed that arecoline aggravated experimental acute ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) in mice. We measured body weight and colon length, evaluated disease activity index, pathology sections, levels of colonic inflammatory factors. exacerbated clinical signs UC response The results 16S rRNA sequencing fecal samples a significant decrease percentage probiotic bacteria Ligilactobacillus, Limosilactobacillus Lactobacillus increase conditionally pathogenic Odoribacter Bacteroides after treatment. Serum untargeted metabolomics intervention reduced ergothioneine, pentostatin, diadenosine tetraphosphate other metabolites modulated nicotinate nicotinamide metabolism, metabolic pathways, glyoxylate dicarboxylate pathways intestinal microorganisms. According to combined microbial metabolite analysis, influences modulating microbiota. summary, it was found treatment injury responses mice, disrupted host's flora, affected changes flora metabolites, thereby exacerbating development inflammation. Therefore, consumption nut can be associated with risk aggravating UC.
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3236 - 3236
Опубликована: Март 12, 2024
Ulcerative colitis (UC) is a chronic inflammatory disorder affecting the colon, with symptomatology influenced by factors including environmental, genomic, microbial, and immunological interactions. Gut microbiota dysbiosis, characterized bacterial population alterations, contributes to intestinal homeostasis disruption aberrant immune system activation, thereby exacerbating state. This study assesses therapeutic efficacy of intraperitoneal (IP) injected flavonoids (apigenin, luteolin, xanthohumol) in reduction parameters modulation gut murine model ulcerative colitis. Flavonoids interact modulating their composition serving as substrates for fermentation into other anti-inflammatory bioactive compounds. Our results demonstrate effectiveness luteolin xanthohumol treatment enhancing relative abundance microorganisms, attenuating pro-inflammatory species. Moreover, all three exhibit cytokine levels, strongly demonstrating utility alleviating associated physical UC symptoms. suggests that this molecule potential alternative or co-therapy conventional pharmacological interventions, potentially mitigating adverse effects. A limited impact on observed apigenin, attributed its solubility constraints via chosen administration route, resulting accumulation mesentery.
Язык: Английский
Процитировано
8
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(24), С. 13593 - 13609
Опубликована: Июнь 5, 2024
Inflammatory bowel disease (IBD) is a recurrent inflammatory condition affecting the gastrointestinal tract, and its clinical treatment remains suboptimal. Probiotics have shown effectiveness in alleviating dextran sulfate sodium salt (DSS)-induced colitis, exhibiting strain-specific anti-inflammatory properties. In this study, we compared therapeutic effects of five strains Bifidobacterium bifidum isolated from healthy adult feces on DSS-induced colitis mice. Additionally, investigated underlying mechanisms by examining gut microbiota composition microbial metabolome. Our findings highlighted superior efficacy B. M1-3 to other strains. It significantly improved symptoms, mitigated barrier disruption, reduced colonic inflammation DSS-treated Moreover, analysis revealed that increased abundance diversity microbiota. Specifically, it Muribaculaceae, Lactobacillus, Bacteroides, Enterorhabdus, while decreasing Escherichia-Shigella. Furthermore, our nontargeted metabolomics illustrated had regulatory effect various metabolic pathways, including tyrosine metabolism, lysine degradation, tryptophan metabolism. Importantly, confirmed efficiency was dependent These results are conducive development probiotic products for colitis.
Язык: Английский
Процитировано
8
Food Bioscience, Год журнала: 2024, Номер 61, С. 104802 - 104802
Опубликована: Июль 24, 2024
Язык: Английский
Процитировано
6
Microbiological Research, Год журнала: 2024, Номер 283, С. 127677 - 127677
Опубликована: Март 6, 2024
Язык: Английский
Процитировано
5
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(5)
Опубликована: Авг. 13, 2024
The demand for functional food is rising in tandem with the prevalence of chronic diseases. Probiotics play a crucial role development, yet their ability to confer health benefits host remains topic debate according Food and Agriculture Organization/World Health Organization requirements. application culturomics, innovative isolation techniques, within realm probiotics increasingly deemed essential fully harnessing latent potential microbial reservoirs. Nevertheless, its confined predominantly human fecal sources. Following integration probiogenomics, significant advancements have been made safety assessment probiotics. However, adoption novel probiotic microorganisms has match requisite pace. Progress research concerning host-probiotic interactions by employing omics technologies, particularly animal models, notable. Nonetheless, comprehensive elucidation mechanisms action trial studies are lagging behind. Additionally, viability probiotics, spanning from production as foods transit colon, markedly improved through encapsulation techniques. opportunities exploration persist regarding alternative coating materials diverse methodologies. Furthermore, there discernible transition domain probiotic-based foods, shifting away primarily dairy-centric focus toward inclusion broader array categories. This review addresses critical issues ranging sources techniques final developments. while doing so, it explores probiogenomics applications characterization, investigations into interactions, strategies stabilization under harsh environmental conditions.
Язык: Английский
Процитировано
4
Archives of Microbiology, Год журнала: 2025, Номер 207(4)
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0