Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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Advances in Nanotechnology for Biofilm Inhibition

ACS Omega, Год журнала: 2023, Номер 8(24), С. 21391 - 21409

Опубликована: Июнь 7, 2023

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible range multidrug-resistant pathogens. These pathogens show reduced susceptibility intracellular survival. However, current methods for treating biofilms, such smart materials targeted drug delivery systems, not been found effective in preventing biofilm formation. To address this challenge, nanotechnology provided innovative solutions formation by clinically relevant Recent advances nanotechnological strategies, including metallic nanoparticles, functionalized dendrimers, polymeric cyclodextrin-based delivery, solid lipid polymer conjugates, liposomes, may provide valuable technological against infectious diseases. Therefore, it is imperative conduct comprehensive review summarize the recent advancements limitations advanced nanotechnologies. present Review encompasses summary agents, mechanisms that lead formation, impact on human health. In nutshell, offers survey managing infections. A detailed presentation how these strategies improve control prevent key objective mechanisms, applications, prospects nanotechnologies better understanding

Язык: Английский

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Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Advanced Science, Год журнала: 2023, Номер 10(22)

Опубликована: Май 31, 2023

Abstract Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is vaccine. Antigens are most components in vaccines. Generally, antigens vaccines can be divided into two categories: pre‐defined unidentified antigens. Although, loaded with predefined commonly used, vaccine mixed antigens, especially whole cells or cell lysates, a very promising approach, such obviate some limitations Their advantages include, but not limited to, inclusion of pan‐spectra (all kinds of) inducing pan‐clones specific T cells, overcoming heterogeneity cells. In this review, recent advances based on whole‐tumor either summarized. terms focus applying water‐soluble lysates as Recently, utilizing has become feasible. Considering that pre‐determined antigen‐based (mainly peptide‐based mRNA‐based) various limitations, developing alternative.

Язык: Английский

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The quest for nanoparticle-powered vaccines in cancer immunotherapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Язык: Английский

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Hypoxia-Targeted-Therapy: Mussel-Inspired hollow polydopamine nanocarrier containing MoS2 nanozyme and Tirapazamine with Anti-Angiogenesis Property for synergistic tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 396 - 414

Опубликована: Янв. 20, 2025

Язык: Английский

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Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Язык: Английский

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Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 94 - 114

Опубликована: Авг. 7, 2023

Immunogenic cell death (ICD) is a unique mode of death, which can release immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens to trigger long-term protective antitumor immune responses. Thus, amplifying "eat me signal" during tumor ICD cascade critical for cancer immunotherapy. Some therapies (radiotherapy, photodynamic therapy (PDT), photothermal (PTT), etc.) inducers (chemotherapeutic agents, have enabled initiate and/or facilitate activate Recently, nanostructure-based drug delivery systems been synthesized inducing through combining treatment chemotherapeutic photosensitizers PDT, transformation agents PTT, radiosensitizers radiotherapy, etc., loaded at an appropriate dosage in the designated place time, contributing higher efficiency lower toxicity. Also, immunotherapeutic combination with produce synergetic effects, thus potentiating Overall, our review outlines emerging inducers, nanostructure loading diverse evoke chemoradiotherapy, PTT or agents. Moreover, we discuss prospects challenges harnessing induction-based immunotherapy, highlight significance multidisciplinary interprofessional collaboration promote optimal translation this strategy.

Язык: Английский

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Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

ACS Nano, Год журнала: 2023, Номер 17(11), С. 9826 - 9849

Опубликована: Май 19, 2023

The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment cancer and a variety infectious diseases due to their superior biocompatibility, lower toxicity reduced immunogenicity. Particularly, stimuli-responsive nanocarriers show great promise for delivering antigens adjuvants targeted immune cells, preventing antigen degradation clearance, increasing the uptake specific antigen-presenting thereby sustaining adaptive responses improving immunotherapy certain diseases. In this review, most recent advances utilization stimulus-responsive polymer-based immunotherapeutic applications are presented. These sophisticated with diverse functions, aimed at administration disease prevention immunotherapy, further classified into several active domains, including pH, temperature, redox, light ultrasound-sensitive intelligent nanodelivery systems. Finally, potential strategies future design multifunctional next-generation by integrating materials science biological interface proposed.

Язык: Английский

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Nanovaccines: An effective therapeutic approach for cancer therapy

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 115992 - 115992

Опубликована: Дек. 9, 2023

Cancer vaccines hold considerable promise for the immunotherapy of solid tumors. Nanomedicine offers several strategies enhancing vaccine effectiveness. In particular, molecular or (sub) cellular can be delivered to target lymphoid tissues and cells by nanocarriers nanoplatforms increase potency durability antitumor immunity minimize negative side effects. Nanovaccines use nanoparticles (NPs) as carriers and/or adjuvants, offering advantages optimal nanoscale size, high stability, ample antigen loading, immunogenicity, tunable presentation, increased retention in lymph nodes, promotion. To induce immunity, cancer rely on tumor antigens, which are administered form entire cells, peptides, nucleic acids, extracellular vesicles (EVs), cell membrane–encapsulated NPs. Ideal stimulate both humoral while overcoming tumor-induced immune suppression. Herein, we review key properties nanovaccines highlight recent advances their development based structure composition various (including synthetic semi (biogenic) nanocarriers. Moreover, discuss cell–derived those whole-tumor-cell components, EVs, NPs, hybrid membrane–coated NPs), nanovaccine action mechanisms, challenges immunocancer therapy translation clinical applications.

Язык: Английский

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