Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(49)
Опубликована: Авг. 23, 2024
Abstract
Molecular
spherical
nucleic
acids
(m‐SNAs)
are
a
second
generation
of
(SNAs),
which
significance
in
potential
application
targeted
delivery
or
gene
regulation
due
to
their
defined
molecular
structures.
Nevertheless,
m‐SNAs
typically
involve
single
DNA
sequence
greatly
limits
its
functions
as
either
targeting
purpose
regulation.
In
response,
we
proposed
here
third
generation,
supramolecular
(Supra‐SNAs)
with
two
different
sequences
achieve
both
above‐mentioned
functions.
Specifically,
constructed
series
self‐assembly
structures
by
coupling
cell
membrane
receptor
(i.e.,
nucleolin)‐recognizing
aptamer
(AS1411)‐modified
adamantine
probe
and
human
epithelial
growth
factor
2
(HER2)
antisense‐functionalized
β‐cyclodextrin
specifically
inhibit
the
overexpression
HER2
proteins
for
regulations.
comparison
m‐SNA
precursors,
such
Supra‐SNA
exhibited
enhanced
levels
resistance
nuclease
degradation,
cellular
uptake,
capabilities
tumor
retention
capacity.
We
demonstrated
that
Supra‐SNAs
optimal
suppression
rates
apoptosis
via
phosphatidylinositol
3‐kinase/protein
kinase
B
signaling
pathway.
The
well‐defined
provide
an
attractive
platform
investigating
interrelationship
between
structure
property
at
level.
Theranostics,
Год журнала:
2023,
Номер
13(15), С. 5501 - 5544
Опубликована: Янв. 1, 2023
Photodynamic
Therapy
(PDT)
is
an
approved
treatment
modality,
which
presently
receiving
great
attention
due
to
its
limited
invasiveness,
high
selectivity
and
susceptibility
drug
resistance.Another
related
research
area
currently
expanding
rapidly
the
development
of
novel
theranostic
agents
based
on
combination
PDT
with
different
imaging
technologies,
allows
for
both
therapy
diagnosis.This
can
help
address
issues
suboptimal
biodistribution
through
regional
imaging,
while
therapeutic
enable
effective
personalized
therapy.In
this
review,
we
describe
compounds,
whose
structures
combine
photosensitizers
probes
-including
examples
near-infrared
optical
magnetic
resonance
(MRI)
nuclear
(PET
or
SPECT),
generating
candidates.We
have
intentionally
focused
our
already
been
investigated
preclinically
in
vivo
order
demonstrate
potential
such
clinical
applications.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(27)
Опубликована: Авг. 26, 2023
As
cancer
markers,
hydrogen
peroxide
(H2
O2
)
and
viscosity
play
an
essential
role
in
the
development
of
tumors.
Meanwhile,
based
on
performance
near-infrared
(NIR)
fluorescence
imaging
high
efficiency
photodynamic
therapy
(PDT)
photothermal
(PTT)
synergistic
therapy,
it
is
urgent
to
develop
a
dual-key
viscosity)
activated
probe
for
phototherapy.
Herein,
NIR-I/II
named
BX-B
reported.
In
presence
both
H2
viscosity,
signal
NIR-I
(810
nm)
NIR-II
(945
can
be
released.
,
PDT
PTT
effects
are
observed.
used
monitor
its
therapeutic
cells
tumor-bearing
mice
due
increased
caused
by
PTT.
addition,
tumors
treated
with
almost
completely
ablated
after
laser
irradiation
therapy.
This
work
provides
reliable
platform
effective
treatment
immediate
evaluation
effects.
Abstract
The
integration
of
robust
photon‐absorption
capacity,
high
reactive
oxygen
species
yields
and
photothermal
conversion
efficiency
(PCE)
into
a
single
phototheranostic
nano‐agents
is
ideal
but
rarely
reported.
This
study
employed
dual‐acceptor
engineering
strategy
utilizing
isoindigo
selenium‐substituted
[1,2,5]thiadiazolo[3,4‐
c
]pyridine
to
augment
the
molar
extinction
coefficient
spin‐orbit
coupling
effect,
respectively,
resulting
in
substantial
enhancement
ability
non‐radiative
decay
energy‐release
process
donor‐acceptor
type
phototherapy
molecules.
As
optimal
agent,
IID‐PSe
exhibited
two
times
that
photosensitizer,
excellent
1
O
2
yield
(15%)
PCE
(34%),
exhibiting
great
potential
for
phototherapy.
After
encapsulating
with
DSPE‐PEG2000,
NPs
showed
anti‐tumor
both
vitro
vivo.
work
provides
an
effective
idea
designing
high‐performance
photosensitive
dyes
output.
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
An
overview
of
cyanine
dye-based
phototherapy
agents,
including
the
design
strategies,
relationships
between
molecular
structures
and
properties,
as
well
applications
in
photodynamic
therapy,
photothermal
multimodal
combined
therapy.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(10)
Опубликована: Дек. 9, 2023
Small
molecular
organic
optical
agents
with
synergistic
effects
of
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
hold
credible
promise
for
anti-tumor
by
overcoming
individual
drawbacks
enhancing
photon
utilization
efficiency.
However,
developing
effective
dual-function
PTT-PDT
photosensitizers
(PSs)
efficient
phototherapy
remains
challenging.
Here,
a
benz[c,d]indolium-substituted
hemicyanine
named
Rh-BI,
which
possesses
high
conversion
efficiency
41.67%
exhaustively
suppressing
fluorescence
emission,
is
presented.
Meanwhile,
the
rotating
phenyl
group
at
meso-site
induces
charge
recombination
to
enhance
molar
extinction
coefficient
up
13.58
×
10
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(40)
Опубликована: Июнь 3, 2023
Abstract
Unpredictable
in
vivo
therapeutic
feedback
of
reactive
oxygen
species
(ROS)
efficiency
is
the
major
bottleneck
photodynamic
therapy
(PDT).
Herein,
novel
PDT‐based
nanotheranostics
Pa–Mn&CH‐A@P
are
elaborately
constructed
for
tracking
biodistribution
and
situ
self‐reporting
PDT,
which
innovatively
unites
magnetic
resonance
imaging
(MRI)
chemiluminescence
(CL)
signals.
Taking
advantages
versatility
lanthanide
coordination
chemistry
flash
nanoprecipitation
(FNP)
technology,
photosensitizers,
MRI,
CL
agents
unprecedently
integrated
within
a
stable
uniform
nanotheranostic.
Specifically,
MRI
signal
offers
detailed
dose
distribution
with
high‐spatial
resolution,
timely
performs
evaluation
ROS
generation
high
sensitivity.
This
dual‐modal
MRI/CL
nanotheranostic
makes
breakthrough
fidelity
oral
tumor,
conquering
inherent
unpredictable
obstacles
on
spatially
sensitively
reporting
PDT.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 13, 2024
NIR-II
fluorescent
photosensitizers
as
phototheranostic
agents
hold
considerable
promise
in
the
application
of
mild
photothermal
therapy
(MPTT)
for
tumors,
reactive
oxygen
species
generated
during
photodynamic
can
effectively
disrupt
heat
shock
proteins.
Nevertheless,
exclusive
utilization
these
to
significantly
augment
MPTT
efficacy
has
rarely
been
substantiated,
primarily
due
their
insufficient
performance.
Herein,
high-performance
type
I/II
photosensitizer
(AS2
Chemical Science,
Год журнала:
2022,
Номер
13(43), С. 12840 - 12850
Опубликована: Янв. 1, 2022
The
limited
accumulation
and
poor
radiosensitization
of
radiosensitizers
greatly
reduce
the
therapeutic
effects.
Here,
we
developed
Janus
AuNR-TiO
2
nanomotors
for
deep
cancer
photoacoustic
imaging
enhanced
radiotherapy.
