Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138539 - 138539
Published: May 5, 2024
Language: Английский
Organic Letters, Journal Year: 2023, Volume and Issue: 25(38), P. 7014 - 7019
Published: Sept. 18, 2023
Organoelectrophotocatalytic generation of acyl radicals from formamides and aldehydes to synthesize acylated 3-CF3-2-oxindoles has been developed. This protocol features a monocatalytic system using 9,10-phenanthrenequinone (PQ) both as catalyst hydrogen atom transfer (HAT) reagent, which avoids the use an external HAT metal oxidant. A variety have obtained in satisfactory yields CF3-substituted N-arylacrylamides via tandem radical cyclization.
Language: Английский
Citations
49
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(42), P. 5502 - 5505
Published: Jan. 1, 2024
An organophotoelectrocatalytic method for the C(sp 2 )–H alkylation of heteroarenes with unactivated 3 compounds via dehydrogenation cross-coupling was developed.
Language: Английский
Citations
28
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(16), P. 1913 - 1928
Published: April 24, 2024
Comprehensive Summary Organic fluorine compounds are ubiquitous and pivotally important organic molecules, yet their activation transformation have long been a formidable challenge due to the high energy low reactivity of C—F bonds. electrosynthesis, an environmentally benign synthetic method in chemistry, enables myriad chemical transformations without need for external redox reagents. In recent years, electrochemistry has emerged as powerful tool achieving bonds fluorine‐containing compounds. This review aims succinctly recapitulate latest advancements electrochemical defluorinative delve into reaction design, mechanistic insights, developmental prospects these methods. Key Scientists 1959, Lund was first pioneer electroreduction CF 3 CH group. Electrochemistry lately provided new opportunities efficient conversion fluorides. 2020, Zhou coworkers discovered carboxylation α‐CF alkenes. Lambert colleagues reported electrophotocatalytic amination aryl Electrochemical hydrodefluorination trifluoromethylketones developed by Lennox 2021. same year, Wang Guo disclosed radical alkylation alkenes with Katritzky salts alkyl precursors. Subsequently, Wu Liao described transition‐metal‐free, site‐selective arylation polyfluoroarenes (het)arenes using paired electrophotocatalysis. 2023, numerous efforts were made achieve bond activation. Xia organoboron‐controlled chemoselective sequential (deutero)hydrodefluorination trifluoroacetamides.
Language: Английский
Citations
26
Current Opinion in Electrochemistry, Journal Year: 2024, Volume and Issue: 44, P. 101447 - 101447
Published: Jan. 26, 2024
Language: Английский
Citations
22
Chinese Journal of Chemistry, Journal Year: 2023, Volume and Issue: 41(22), P. 2963 - 2968
Published: June 24, 2023
Comprehensive Summary A photoelectrochemical approach for the C—H silylation of heteroarenes through dehydrogenation cross‐coupling with H 2 evolution has been developed. The depends on hydrogen atom transfer (HAT) from silanes to Cl‐radical generated light‐induced homolytic cleavage Cl , in which was produced by electrochemical oxidation chloride. large number silylated heterocyclic molecules are rapidly constructed satisfactory yields without relying oxidants and metal reagents.
Language: Английский
Citations
40
Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(12), P. 101874 - 101874
Published: Nov. 22, 2023
Novel α-amylase inhibitors play a crucial role in managing diabetes and obesity, contributing to improved public health by addressing these challenging prevalent conditions. Moreover, the synthesis of anti-oxidant agents is essential due their potential combating oxidative stress-related diseases promoting overall health.Synthesis thoisemicarbazone derivatives 2,4-dichlorophenyl acetic acid screened them for biological activities.Thiosemicarbazone (4-13) were synthesized refluxing with sulfuric ethanol get ester (2), which was further refluxed thiosemicarbazide compound (3). Finally, different aromatic aldehydes (3) catalytic amount obtained final products (4-13). Using modern spectroscopic techniques including HR-ESI-MS, 13C-, 1H NMR, structures created confirmed.The showed excellent good inhibitory activity range IC50 values 4.95 ± 0.44 69.71 0.05 µM against enzyme when compared standard drug acarbose (IC50 = 21.55 1.31 µM). In case iron chelating activity, potent better than EDTA 66.43 1.07 µM) 22.43 2.09 61.21 2.83 µM. However, also show 28.30 1.17 64.66 2.43 hydroxyl radical scavenging vitamin C 60.51 1.02 DFT used calculate reactivity factors ionization potential, electronegativity, electron affinity, chemical softness, hardness calculated using frontier molecular orbital (FMO) computations. The docking studies carried out AutoDock Vina understand binding affinities active sites protein.
Language: Английский
Citations
34
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A new photoelectrocatalytic mode permits the synthesis of polycyclic pyrimidin-4-ones through dehydrogenative cyclization malonates with unactivated alkenes.
Language: Английский
Citations
15
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 685, P. 133189 - 133189
Published: Jan. 13, 2024
Language: Английский
Citations
11
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(21), P. 12264 - 12304
Published: Oct. 23, 2024
Electrocatalysis and photocatalysis have been the focus of extensive research efforts in organic synthesis recent decades, these powerful strategies provided a wealth new methods to construct complex molecules. Despite intense efforts, only recently has there significant on combined use two modalities. Nevertheless, past five years witnessed rapidly growing interest area electrophotocatalysis. This hybrid strategy capitalizes enormous benefits using photons as reagents while also employing an electric potential convenient tunable source or sink electrons. Research this topic led number for C-H functionalization, reductive cross-coupling, olefin addition among others. field seen broad range catalyst types, including both metal organocatalysts. Of particular note work with open-shell photocatalysts, which tend comparatively large redox potentials. Electrochemistry provides means generate such species, making electrophotocatalysis particularly amenable intriguing class catalyst. review surveys applied synthesis, organized broadly into oxidative, reductive, neutral transformations.
Language: Английский
Citations
11
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(10), P. 2352 - 2362
Published: April 5, 2024
Abstract While the emergence of electrophotochemistry provides opportunities, such a chemistry at this stage suffers from limited reaction types and high photocatalyst loadings. A self‐catalyzed electrophotosynthesis as well one with low loading is presented. These external‐oxidant‐free cyclizations are enabling applicable to range activated alkenes, affording diverse array thiocyanato heterocycles including 4‐pyrrolin‐2‐ones, isoquinoline‐1,3‐diones, indolo[2,1‐ ]isoquinolin‐6(5 H )‐ones, benzoimidazo[2,1‐ )‐ones indolin‐2‐ones, protocols amenable late‐stage diversification complex molecular architectures gram‐scale syntheses. Sunlight could serve light source, be conducted in an all‐solar‐driven mode using commercially available photovoltaic panel produce electricity.
Language: Английский
Citations
10