Arginine depletion-induced autophagy and metabolic dysregulation are involved in the disease severity of hand, foot, and mouth disease DOI Creative Commons
Yuefei Jin, Wangquan Ji, Liang Zhang

et al.

Virulence, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 28, 2024

Amino acid metabolism provides significant insight into the development and prevention of many viral diseases. Therefore, present study aimed to compare amino profiles hand, foot, mouth disease (HFMD) patients with those healthy individuals further reveal molecular mechanisms HFMD severity. Using UPLC-MS/MS, we determined plasma expression pediatric (mild, n = 42; severe, 43) controls (n 25). Brain tissues from CVA6-infected mice were examined using untargeted metabolomics. Several acids significantly different between three groups. Pathway analysis revealed that arginine, proline, tryptophan are implicated in pathogenesis HFMD. A similar arginine depletion was observed brain mice. Importantly, L-arginine supplementation improved survival rate mice, inhibited virus multiplication, reduced pathological autophagy associated mTOR-autophagy pathway brain. Collectively, as hub metabolite mammalian target rapamycin (mTOR) signaling affecting autophagy, plays an important role severe may serve a potential therapeutic option for critical

Language: Английский

The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside DOI

Shweta Sharma,

Shivani Chawla,

Praveen Kumar

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1843, P. 149123 - 149123

Published: Nov. 1, 2024

Language: Английский

Citations

11
Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control DOI Creative Commons
Mary Kate P. Joyce, Stacy Uchendu,

Amy Arnsten

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Language: Английский

Citations

10
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID DOI Creative Commons
A. Satyanarayan Naidu, Chin‐Kun Wang, Pingfan Rao

et al.

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

Citations

8
The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects DOI Open Access
Luana de Fátima Alves, J. Bernadette Moore, Douglas B. Kell

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9082 - 9082

Published: Aug. 21, 2024

Kynurenic acid (KYNA) is an antioxidant degradation product of tryptophan that has been shown to have a variety cytoprotective, neuroprotective and neuronal signalling properties. However, mammalian transporters receptors display micromolar binding constants; these are consistent with its typically tissue concentrations but far above serum/plasma concentration (normally tens nanomolar), suggesting large gaps in our knowledge transport mechanisms action, the main influx characterized date equilibrative, not concentrative. In addition, it substrate known anion efflux pump (ABCC4), whose vivo activity largely unknown. Exogeneous addition L-tryptophan or L-kynurenine leads production KYNA also many other co-metabolites (including some such as 3-hydroxy-L-kynurenine quinolinic may be toxic). With exception chestnut honey, exists at relatively low levels natural foodstuffs. bioavailability reasonable, terminal element irreversible reaction most pathways, might added exogenously without disturbing upstream metabolism significantly. Many examples, which we review, show valuable bioactivity. Given above, review potential utility nutraceutical, finding significantly worthy further study development.

Language: Английский

Citations

6
Tryptophan Metabolism Disorder-Triggered Diseases, Mechanisms, and Therapeutic Strategies: A Scientometric Review DOI Open Access
Xue Chen, Dong Xu,

Jie Yu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3380 - 3380

Published: Oct. 4, 2024

Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role maintaining metabolic homeostasis health disease. metabolism involved the development progression of immune, nervous, digestive system diseases. Although some excellent reviews on tryptophan exist, there has been no systematic scientometric study yet. Methods: This review provides summarizes research hotspots potential future directions by analyzing annual publications, topics, keywords, highly cited papers sourced from Web Science spanning 1964 to 2022. Results: overview disorder-triggered diseases, mechanisms, therapeutic strategies. Conclusions: The gut microbiota regulates permeability, inflammation, host immunity directly converting indole its derivatives. Gut microbial metabolites regulate activating specific receptors or enzymes. Additionally, kynurenine (KYN) pathway, activated indoleamine-2, 3-dioxygenase (IDO) 2, 3-dioxygenase, affects migration invasion glioma cells COVID-19 depression. IDO inhibitors help improve effectiveness immunotherapy. markers are used for disease therapy, guiding clinical decision-making. serve targets provide new promising strategy neuroprotective/neurotoxic imbalance affecting brain structure function. In summary, this valuable guidance basic application metabolism.

Language: Английский

Citations

5
SIRT1: A likely key for future therapeutic strategies for pain management DOI Creative Commons
Sara Ilari, Saverio Nucera, Lucia Carmela Passacatini

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107670 - 107670

Published: Feb. 20, 2025

Sirtuin 1 (SIRT1), a NAD+ -dependent histone deacetylase, plays crucial role in mitigating oxidative stress, regulating inflammation, and maintaining mitochondrial function. Reduced SIRT1 activity has been linked to elevated pro-inflammatory cytokines, dysfunction, chronic pain, all of which are observed long COVID pathology. Emerging evidence identifies dysfunction stress as central contributors these symptoms. Increases reactive oxygen species (ROS) such superoxide, nitric oxide, peroxynitrite, leading damage, central/peripheral sensitization. Nutraceuticals, particularly the polyphenolic fraction bergamot (BPF), have demonstrated potent antioxidant, anti-inflammatory, antiviral properties. This study highlights BPF's ability modulate rat model inflammation hyperalgesia. It provides novel nitration within nucleus key event inflammatory pain pathogenesis. BPF administration preserved activity, reduced markers malondialdehyde (MDA) 8-hydroxydeoxyguanosine (8-OHdG), minimized post-translational modifications nuclear proteins, including nitration, acetylation, carbonylation. Additionally, it alleviated hyperalgesia allodynia. These findings underscore therapeutic potential polyphenols like reducing inflammation-driven pain. By activating SIRT1, may provide relief for conditions. Further research on SIRT1-targeted therapies is essential combat preventing conditions enhancing treatment options.

Language: Английский

Citations

0
3C-like proteases in SARS-CoV-2 DOI Open Access
Kenana Al Adem, Juliana C. Ferreira,

Adrian J. Villanueva

et al.

Bioscience Reports, Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Coronaviruses constitute a significant threat to the human population. Severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, is highly pathogenic coronavirus that has caused COVID-19 pandemic. It led global viral outbreak with an exceptional spread and high death toll, highlighting need for effective antiviral strategies. 3-chymotrypsin-like protease (3CLpro), main in plays indispensable role SARS-CoV-2 life cycle by cleaving polyprotein produce eleven individual non-structural proteins necessary replication. 3CLpro one of two proteases function new particles. conserved cysteine identical structural folds all known coronaviruses. Inhibitors binding affinity will prevent cleavage polyproteins, thus impeding Multiple strategies have been implemented screen inhibitors against 3CLpro, including peptide-like small molecule covalently non-covalently bind active site, respectively. In addition, allosteric sites identified molecules could make non-competitive 3CLpro. essence, this review serves as comprehensive guide understanding intricacies functional dynamics emphasizing key findings elucidate its SARS-CoV-2. Notably, critical resource recognizing advancements identifying developing COVID-19, some which are already approved clinical use patients.

Language: Английский

Citations

3
Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units DOI Creative Commons
Sabine Kugler, Lisa Hahnefeld, Jan Kloka

et al.

Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125295 - 125295

Published: Oct. 9, 2023

The COVID-19 pandemic challenged the management of technical and human resources in intensive care units (ICU) across world. Several long-term predictors for disease progression have been discovered. However, to support short-term planning medication that can be translated future pandemics are still missing. A workflow was established identify a predictor acute phase patients clinical decision-making. Thirty-two with SARS-CoV-2 infection were recruited on admission ICU data collected. During their hospitalization, plasma samples acquired from each patient multiple occasions, excepting one which only time point possible, proteome (Inflammation, Immune Response Organ Damage panels Olink® Target 96), metabolome lipidome (flow injection analysis liquid chromatography-mass spectrometry) analyzed sample. Patient visits grouped according changes severity based respiratory organ function, evaluated using combination statistical machine learning. resulting this multi-omics approach compared assessment progression. Furthermore, potential markers baseline levels 50 healthy subjects no known or other viral infections. total 124 parameters, 271 proteins 782 unique metabolites lipids assessed. dimensionality dataset reduced, selecting 47 1177 parameters available following down-selection, build learning model. Subsequently, two (C–C motif chemokine 7 (CCL7) carbonic anhydrase 14 (CA14)) lipid (hexosylceramide 18:2; O2/20:0) linked studied Thus, delivering prognosis an upcoming worsening patient's condition up five days advance reasonable accuracy (79 % three prior event, 84 four event) found. Interestingly, predictor's performance complementary clinicians' capabilities foresee patient. This study presents omics-based biomarkers decision-making resource ICU. successfully applied develop aggravation symptoms. methods adapted small cohort studies.

Language: Английский

Citations

8
The role of nonesterified fatty acids in cancer biology: Focus on tryptophan and related metabolism DOI

Abdulla A.-B. Badawy

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: 1869(7), P. 159531 - 159531

Published: Oct. 1, 2024

Language: Английский

Citations

2
Sirtuin 2 regulates neutrophil functions through NAD+ synthesis pathway in virus infection DOI Creative Commons
Zhiyuan Zhang,

Qiuli Yang,

Yingjie Dong

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(7), P. 110184 - 110184

Published: June 5, 2024

Language: Английский

Citations

1