Translational Lung Cancer Research,
Год журнала:
2023,
Номер
12(7), С. 1391 - 1413
Опубликована: Июль 1, 2023
Individuals
with
lung
cancer
(LC)
face
a
variety
of
symptoms
that
significantly
impact
their
lives.
We
use
extensive
patient
input
to
determine
the
relative
importance
and
prevalence
these
identify
which
demographic
features
are
associated
higher
level
disease
burden.We
performed
semi-structured
qualitative
interviews
participants
LC
potentially
important
symptoms.
then
conducted
cross-sectional
study,
in
rated
162
individual
covering
14
symptomatic
themes.
Participant
responses
were
analyzed
by
age,
sex,
disability
status,
duration,
stage,
type
treatment
received,
smoking
history,
among
other
categories.Our
study
had
139
LC.
The
most
prevalent
themes
reported
this
population
fatigue
(85.5%),
impaired
sleep
daytime
sleepiness
(73.5%),
emotional
issues
(73.0%).
greatest
average
(on
scale
0
4,
4
being
impactful)
social
role
dissatisfaction
(1.67),
inability
do
activities
(1.64),
(1.60).
Disability
status
strongest
association
theme
prevalence.
stage
(stage
IV),
receipt
therapy,
experience
also
frequency
themes.Individuals
diverse
disease-specific
affect
daily
Patient
insight
on
is
invaluable
advance
meaningful
therapeutic
interventions.
Science Translational Medicine,
Год журнала:
2024,
Номер
16(737)
Опубликована: Март 6, 2024
Patients
with
cancer
undergoing
chemotherapy
frequently
experience
a
neurological
condition
known
as
chemotherapy-related
cognitive
impairment,
or
“chemobrain,”
which
can
persist
for
the
remainder
of
their
lives.
Despite
growing
prevalence
chemobrain,
both
its
underlying
mechanisms
and
treatment
strategies
remain
poorly
understood.
Recent
findings
suggest
that
chemobrain
shares
several
characteristics
neurodegenerative
diseases,
including
chronic
neuroinflammation,
DNA
damage,
synaptic
loss.
We
investigated
whether
noninvasive
sensory
stimulation
we
term
gamma
entrainment
using
stimuli
(GENUS),
has
been
shown
to
alleviate
aberrant
immune
pathologies
in
mouse
models
neurodegeneration,
could
also
mitigate
phenotypes
mice
administered
chemotherapeutic
drug.
When
concurrently
agent
cisplatin,
GENUS
alleviated
cisplatin-induced
brain
pathology,
promoted
oligodendrocyte
survival,
improved
function
model
chemobrain.
These
effects
persisted
up
105
days
after
treatment,
suggesting
potential
long-lasting
benefits.
However,
when
90
chemotherapy,
only
provided
limited
benefits,
indicating
it
was
most
effective
used
prevent
progression
pathology.
Furthermore,
demonstrated
were
not
but
extended
methotrexate-induced
Collectively,
these
may
represent
versatile
approach
treating
induced
by
different
agents.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(7), С. 2901 - 2926
Опубликована: Март 11, 2024
Despite
the
considerable
advancements
in
chemotherapy
as
a
cornerstone
modality
cancer
treatment,
prevalence
of
complications
and
pre-existing
diseases
is
on
rise
among
patients
along
with
prolonged
survival
aging
population.
The
relationships
between
these
disorders
are
intricate,
bearing
significant
influence
quality
life
individuals
presenting
challenges
for
prognosis
outcomes
malignancies.
Herein,
we
review
prevailing
comorbidities
that
often
accompany
summarize
lessons
to
learn
from
inadequate
research
management
this
scenario,
an
emphasis
possible
strategies
reducing
potential
alleviating
comorbidities,
well
overview
current
preclinical
models
practical
advice
establishing
bio-faithful
such
complex
context.
Metabolic Brain Disease,
Год журнала:
2025,
Номер
40(3)
Опубликована: Март 14, 2025
Abstract
Background:
The
cognitive
alterations
observed
in
individuals
undergoing
cancer
treatments
have
garnered
more
attention
recently.
Chemotherapy
can
reduce
nicotinamide
adenine
dinucleotide
(NAD+)
levels
by
inhibiting
phosphoribosyl
transferase
(NAMPT).
This
reduction
make
cells
susceptible
to
oxidative
damage
and
death
may
also
affect
non-cancerous
cells,
particularly
the
brain
cells.
During
chemotherapy-induced
suppression,
downregulation
of
NAMPT-mediated
NAD+/Sirtuin
1
(SIRT1)
pathway
cause
dyscognition.
Objective:
study
aimed
assess
role
quercetin
analogues
chemobrain
associated
mechanisms.
Methods:
potential
its
derivatives
interaction
with
NAMPT
SIRT1
proteins
was
performed
using
computational
studies
followed
their
vitro
evaluation
SH-SY5Y
Molecular
docking
simulation
human
were
performed.
Differentiated
cell
lines
treated
selected
against
Methotrexate
5-Fluorouracil
(MF)
toxicity,
subjecting
cytotoxicity
assay,
flow
cytometry,
RT-PCR
analysis.
Results:
Quercetin,
Rutin,
Isoquercetin
showed
interactions
necessary
activation
process
both
proteins.
Cytotoxicity
cytometric
demonstrated
that
phytochemicals
shield
differentiated
from
MF
toxicity.
As
determined
investigations,
gene
mRNA
expression
higher
test
drug-treated
at
(0.12,
0.6
µM),
rutin,
isoquercetin
(16,
80
µM)
lower
MF-treated
Conclusion:
treatment
alleviated
CICI
targeting
proteins,
which
could
lead
identification
effective
strategies
for
chemobrain.
Graphical
abstract
Multiple
myeloma
is
a
haematological
malignancy
characterized
by
significant
morbidity
and
mortality.
This
study
sought
to
develop
an
in-depth
understanding
of
patients'
lived
experiences
relapsed
or
refractory
multiple
(RRMM)
its
treatment,
identify
which
features
treatment
were
most
important
them.Qualitative
interviews
focus
groups
(FGs)
conducted
with
32
people
living
RRMM
across
Canada.
In
Phase
1,
focused
on
participants'
accounts
their
the
disease
laid
groundwork
for
FGs
(Phase
2).
The
developed
deeper
priorities.
Interview
FG
transcripts
coded
emergent
themes
patterns.The
identified
side
effects
that
had
impacts
lives,
including
physical,
cognitive,
psychological/emotional
effects.
Participants
also
specific
(attributes)
them.
These
compiled
into
list
used
in
understand
Higher
prioritized
attributes
were:
life
expectancy,
physical
cognitive
effects,
financial
impact.
Mode
administration,
intervals,
psychological
sleep/mood
as
lower
priorities.RRMM
treatments
impact
importantly
quality-of-life
range
domains.
Patients
could
enhance
minimize
offset
burdens.A
clear
articulation
patient
priorities
can
contribute
efforts
design
concerns
mind,
thereby
promoting
more
patient-centered
approach
care.
Cell Reports Medicine,
Год журнала:
2022,
Номер
3(10), С. 100750 - 100750
Опубликована: Сен. 7, 2022
As
COVID-19
cases
exceed
hundreds
of
millions
globally,
many
survivors
face
cognitive
challenges
and
prolonged
symptoms.
However,
important
questions
about
the
effects
remain
unresolved.
In
this
cross-sectional
online
study,
478
adult
volunteers
who
self-reported
a
positive
test
for
(mean
=
30
days
since
most
recent
test)
perform
significantly
worse
than
pre-pandemic
norms
on
measures
processing
speed,
reasoning,
verbal,
overall
performance,
but
not
short-term
memory,
suggesting
domain-specific
deficits.
Cognitive
differences
are
even
observed
in
participants
did
require
hospitalization.
Factor
analysis
health-
COVID-related
questionnaires
reveals
two
clusters
symptoms-one
that
varies
mostly
with
physical
symptoms
illness
severity,
one
mental
health.
performance
is
positively
correlated
global
measure
encompassing
symptoms,
broadly
describes
health,
subjective
experience
"long
COVID"
relates
to
deficits,
especially
executive
dysfunction.
Oxford Open Immunology,
Год журнала:
2022,
Номер
3(1)
Опубликована: Янв. 1, 2022
Abstract
Neuroinflammation
is
a
process
triggered
by
an
attack
on
the
immune
system.
Activation
of
microglia
in
response
to
system
challenge
can
lead
significant
impact
cognitive
processes,
such
as
learning,
memory
and
emotional
regulation.
Long
Covid
ongoing
problem,
affecting
estimated
1.3
million
people
within
UK
alone,
one
its
more
significant,
yet
unexplained,
symptoms
brain
fog.
Here,
we
discuss
potential
role
neuroinflammation
difficulties.
Inflammatory
cytokines
have
been
found
play
reductions
LTP
LTD,
reduction
neurogenesis,
dendritic
sprouting.
The
behavioural
consequences
impacts
are
discussed.
It
hoped
that
this
article
will
allow
for
greater
examination
effects
inflammatory
factors
function,
most
particularly
terms
their
chronic
conditions.
