Drosophila as a model for ageing

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2017, Номер 1864(9), С. 2707 - 2717

Опубликована: Сен. 29, 2017

Язык: Английский

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The complex role of adipokines in obesity, inflammation, and autoimmunity

Clinical Science, Год журнала: 2021, Номер 135(6), С. 731 - 752

Опубликована: Март 1, 2021

Abstract The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since discovery of leptin 1994, multitude studies have characterized pathological changes that occur within adipose tissue obese state. One significant change dysregulation adipokine production. Adipokines are an indispensable link between metabolism optimal immune system function; however, their contributes low-grade inflammation pathology. Herein, I will highlight current knowledge on structure physiological function, focus known roles these factors modulation response. also discuss adipokines rheumatic autoimmune diseases.

Язык: Английский

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Regulation of Body Size and Growth Control

Genetics, Год журнала: 2020, Номер 216(2), С. 269 - 313

Опубликована: Окт. 1, 2020

Abstract The control of body and organ growth is essential for the development adults with proper size proportions, which important survival reproduction. In animals, adult determined by rate duration juvenile growth, are influenced environment. nutrient-scarce environments in more time needed period can be extended delaying maturation, whereas rapidly completed nutrient-rich conditions. This flexibility requires integration environmental cues developmental signals that govern internal checkpoints to ensure maturation does not begin until sufficient tissue has occurred reach a size. Target Rapamycin (TOR) pathway primary cell-autonomous nutrient sensor, while circulating hormones such as steroids insulin-like factors main systemic regulators animals. We discuss recent findings Drosophila melanogaster showing environment growth-sensing mechanisms, involving TOR other growth-regulatory pathways, converge on insulin steroid relay centers responsible adjusting development, response external addition this, also monitored coordinated whole-body timing through modulation signaling. coordination involves interorgan communication mediated peptide 8 status. Together, these multiple nutritional feed into neuroendocrine hubs controlling signaling, serving at progression toward delayed. review focuses mechanisms conditions modulate size, highlights conserved architecture this system, made prime model understanding

Язык: Английский

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Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health

Cell Metabolism, Год журнала: 2017, Номер 25(3), С. 522 - 534

Опубликована: Март 1, 2017

Язык: Английский

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Metabolism and growth adaptation to environmental conditions in Drosophila

Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 77(22), С. 4523 - 4551

Опубликована: Май 24, 2020

Organisms adapt to changing environments by adjusting their development, metabolism, and behavior improve chances of survival reproduction. To achieve such flexibility, organisms must be able sense respond changes in external environmental conditions internal state. Metabolic adaptation response altered nutrient availability is key maintaining energy homeostasis sustaining developmental growth. Furthermore, variables exert major influences on growth final adult body size animals. This plasticity depends adaptive responses state cues that are essential for processes. Genetic studies have shown the fruit fly Drosophila, similarly mammals, regulates its growth, environment through several hormones including insulin, peptides with glucagon-like function, steroid hormones. Here we review emerging evidence showing various sensed different organs that, via inter-organ communication, relay information neuroendocrine centers control insulin signaling. focuses endocrine regulation highlighting recent advances role system as a signaling hub integrates inputs drives responses.

Язык: Английский

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Roles of the insulin signaling pathway in insect development and organ growth

Peptides, Год журнала: 2018, Номер 122, С. 169923 - 169923

Опубликована: Фев. 16, 2018

Язык: Английский

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A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition

Developmental Cell, Год журнала: 2018, Номер 46(4), С. 456 - 469.e4

Опубликована: Авг. 1, 2018

Язык: Английский

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The Lysosome at the Intersection of Cellular Growth and Destruction

Developmental Cell, Год журнала: 2020, Номер 54(2), С. 226 - 238

Опубликована: Июнь 30, 2020

Язык: Английский

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Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms

Science China Life Sciences, Год журнала: 2021, Номер 64(8), С. 1236 - 1280

Опубликована: Апрель 22, 2021

Язык: Английский

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Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(42)

Опубликована: Окт. 1, 2018

Significance Mosquitoes pose an enormous threat to humans by transmitting numerous dangerous diseases. To become reproductively competent and effective disease vectors, it is crucial for them achieve optimal body size nutritional status. Elucidation of these processes in mosquitoes has been hampered the lack classic genetics tools. CRISPR-Cas9 disruption fat-body–specific serotonin receptor Aa5HT2B impairs growth lipid accumulation Aedes aegypti mosquitoes, vectors dengue fever, yellow Zika virus. controls insulin-like peptides. Using approach, we have uncovered differential roles peptides control metabolism, provided a link between blood feeding signaling.

Язык: Английский

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