Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 185 - 197
Опубликована: Янв. 1, 2023
Язык: Английский
Autoimmunity Reviews, Год журнала: 2022, Номер 21(5), С. 103071 - 103071
Опубликована: Фев. 16, 2022
Язык: Английский
Процитировано
108
Autoimmunity Reviews, Год журнала: 2021, Номер 21(3), С. 103012 - 103012
Опубликована: Дек. 9, 2021
The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal these two entities with molecular mimicry, hyperstimulation dysregulation of the immune system as plausible mechanisms. recent pandemic new virus, i.e., SARS-CoV-2, resulted in numerous addressing potential this virus to induce autoimmunity and, eventually, disease. In addition, it also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening Therefore, topic 15th Dresden Symposium on Autoantibodies was focused SARS-CoV-2 era. This report is collection distillation topics presented at meeting.
Язык: Английский
Процитировано
78
Expert Review of Clinical Immunology, Год журнала: 2022, Номер 18(7), С. 653 - 666
Опубликована: Июнь 6, 2022
Post-COVID syndrome (PCS) is recognized as a new entity in the context of SARS-CoV-2 infection. Though its pathogenesis not completely understood, persistent inflammation from acute illness and development autoimmunity play critical role development.The mechanisms involved emergence PCS, their similarities with post-viral post-care syndromes, inclusion spectrum possible targets for treatment.An autoimmune phenomenon plays major most causative theories explaining PCS. There need both PCS definition classification criteria (including severity scores). Longitudinal controlled studies are necessary to better understand this entity, find what additional factors participate into development. With high prevalence COVID-19 cases worldwide, together current evidence on latent we may observe an increase diseases (ADs) coming years. Vaccination's effect ADs will also receive attention future. Health social care services develop framework deal
Язык: Английский
Процитировано
32
Sexuality and Disability, Год журнала: 2024, Номер 42(3), С. 567 - 589
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
6
American Journal of Reproductive Immunology, Год журнала: 2021, Номер 86(6)
Опубликована: Авг. 18, 2021
Oogenesis, the process of egg production by ovary, involves a complex differentiation program leading to functional oocytes. This comprises sequential pathway steps that are finely regulated. The question related SARS-CoV-2 infection and fertility has been evoked for several reasons, including mechanism molecular mimicry, which may contribute female infertility generation deleterious autoantibodies, possibly contributing onset an autoimmune disease in infected patients.The immunological potential peptides shared between spike glycoprotein oogenesis-related proteins; Thus we planned systematic study improve our understanding possible effects on using angle mimicry as starting point.A library 82 human proteins linked oogenesis was assembled at random from UniProtKB database oogenesis, uterine receptivity, decidualization, placentation key words. For analyses, artificial polyprotein built joining sequences oogenesis-associated proteins. These were analyzed searching Immune Epitope DataBase immunoreactive epitopes hosting pentapeptides.SARS-CoV-2 found share 41 minimal immune determinants, is, pentapeptides, with 27 relate placentation. All pentapeptides identified, exception four, also present glycoprotein-derived have experimentally validated immunoreactive.
Язык: Английский
Процитировано
29
Journal of Translational Autoimmunity, Год журнала: 2025, Номер 10, С. 100280 - 100280
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Pathophysiology, Год журнала: 2022, Номер 29(2), С. 243 - 280
Опубликована: Июнь 3, 2022
In our continuing examination of the role exposomes in autoimmune disease, we use this review to focus on pathogens. Infections are major contributors pathophysiology diseases through various mechanisms, foremost being molecular mimicry, when structural similarity between pathogen and a human tissue antigen leads reactivity even disease. The three best examples oral pathogens, SARS-CoV-2, herpesviruses. Oral pathogens reach gut, disturb microbiota, increase gut permeability, cause local inflammation, generate autoantigens, leading systemic multiple reactivities, autoimmunity. COVID-19 pandemic put spotlight which has been called “the virus.” We explore detail evidence supporting this. also describe how viruses, particular herpesviruses, have induction many different diseases, detailing mechanisms involved. Lastly, discuss microbiome beneficial microbiota that populate it. look at disorders, because its regulating immune system. Dysbiosis can lead disorders. conclude understanding precise roles relationships shared by all these factors comprise exposome identifying early events root causes disorders help us develop more targeted therapeutic protocols for management worldwide epidemic
Язык: Английский
Процитировано
16
Vaccines, Год журнала: 2024, Номер 12(5), С. 539 - 539
Опубликована: Май 14, 2024
Spike protein sequences in SARS-CoV-2 have been employed for vaccine epitopes, but many short constituent (SCSs) the spike are present human proteome, suggesting that some anti-spike antibodies induced by infection or vaccination may be autoantibodies against proteins. To evaluate this possibility of “molecular mimicry” silico and vitro, we exhaustively identified common SCSs (cSCSs) found both proteins bioinformatically. The commonality between two systems seemed to coincidental, only cSCSs were likely relevant potential self-epitopes based on three-dimensional information. Among three raised cSCS-containing peptides, antibody EPLDVL showed high affinity reacted with an EPLDVL-containing peptide from unc-80 homolog protein. Western blot analysis revealed also several expressed mainly small intestine, ovary, stomach. Taken together, these results most incapable inducing at least functions as a self-epitope, serious infection-induced vaccine-induced humans. High-risk cSCSs, including EPLDVL, should excluded epitopes prevent autoimmune disorders.
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2023, Номер 11(7), С. 1898 - 1898
Опубликована: Июль 4, 2023
The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed development a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients Methods: A retrospective was conducted patients with new-onset diseases induced by post-COVID-19 between March 2021 December 2022, in two referral hospitals Mexico City Argentina. evaluated who received developed recent-onset diseases. Results: Twenty-eight after vaccine. median age 56.9 ± 21.7 years, 14 females males. observed were neurological 13 (46%), hematological 12 (42%), thrombotic 10 (28%), hemolytic anemia (7.1%). Rheumatological disorders present (7.1%), endocrine one patient (3.5%). Principio del formulario Conclusion: Although is generally safe, it can lead adverse effects. Thrombosis Guillain-Barre most frequent our group patients.
Язык: Английский
Процитировано
7
Expert Review of Vaccines, Год журнала: 2022, Номер 21(9), С. 1177 - 1184
Опубликована: Июнь 13, 2022
COVID-19 has had a catastrophic impact on the world. The current death toll far exceeds 6 million and large numbers of patients are experiencing long-term medical psychiatric morbidity from infection. immunopathology severe is now better understood. In severely affected patients, there chaotic, destructive immune response triggered by SARS-CoV-2, where autoimmunity features prominently.COVID-19 vaccines ensure coordinated, balanced to future SARS-CoV-2 rapid global deployment effective been hindered financial, logistical political barriers. Of concern increasing vaccine hesitancy caused unfounded conspiracy theories adverse effects, often fueled misinformation disinformation social media.This perspective discusses potential so-called Autoimmune/autoinflammatory Syndrome Induced Adjuvants (ASIA) uptake. Proponents ASIA syndrome have inappropriately linked infertility HPV recently suggested antigenic cross-reactivity between ovarian follicles. also fear leading cause hesitancy. Vaccine spurious disorders such as likely harm individuals delay vaccination efforts emergence monoclonal antibody-resistant variants, thereby prolonging pandemic.
Язык: Английский
Процитировано
10