A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Advanced Materials, Год журнала: 2023, Номер 35(19)

Опубликована: Фев. 22, 2023

Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for later situ local injections cover wounds long-termly accelerated healing via synergistic effect magnesium ions (Mg2+ ) engineered small extracellular vesicles (sEVs). The self-healing bio-adhesive properties make it ideal physical barrier At inflammation stage, formulation recruit bone marrow-derived mesenchymal stem cells sites stimulate them toward neurogenic differentiation, while providing immune microenvironment macrophage reprogramming. proliferation stage repair, robust occurs newly differentiated neural released Mg2+ , allowing regenerative take place at site. provides novel platform combined DW therapy.

Язык: Английский

---

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Год журнала: 2023, Номер 10(13)

Опубликована: Март 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Язык: Английский

---

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

---

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Язык: Английский

---

Roles of MXenes in biomedical applications: recent developments and prospects

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Март 2, 2023

Abstract ....With the development of nanomedical technology, application various novel nanomaterials in biomedical field has been greatly developed recent years. MXenes, which are new inorganic with ultrathin atomic thickness, consist layered transition metal carbides and nitrides or carbonitrides have general structural formula M n+1 X n T x (n = 1–3). Based on unique features such as thickness high specific surface area, their excellent physicochemical properties, photothermal conversion efficiency antibacterial MXenes widely applied field. This review systematically summarizes MXene-based materials biomedicine. The first section is a brief summary synthesis methods modification strategies, followed by focused overview analysis applications biosensors, diagnosis, therapy, agents, implants, among other areas. We also two popular research areas: wearable devices immunotherapy. Finally, difficulties progress clinical translation briefly discussed. Graphical

Язык: Английский

---

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Апрель 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Язык: Английский

---

Glycopeptide‐Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

Advanced Functional Materials, Год журнала: 2023, Номер 33(29)

Опубликована: Апрель 23, 2023

Abstract Excessive inflammation, bacterial infection, and blocked angiogenesis make diabetic wound healing challenging. Multifunctional dressings have several advantages in healing. In addition, the pH regulation of microenvironment is shown to be a key factor that promotes skin regeneration through cellular immune regulation. However, few reports focused on development functional with ability regulate promote This study presents novel approach for regulating sites using glycopeptide‐based hydrogel consisting modified hyaluronic acid poly(6‐aminocaproic acid). forms network Schiff base interactions metal complexation, which suppresses inflammation accelerates during Hydrogels not only adequate mechanical properties self‐healing but can also support tissue adhesion. They secretion inducible cAMP early repressor, polarization macrophages toward M2 type. The vivo results confirm repair by exerting rapid anti‐inflammatory effects promoting angiogenesis. Therefore, this system represents an effective strategy treating wounds.

Язык: Английский

---

Supramolecular Photothermal Cascade Nano‐Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm‐Associated Tooth‐Extraction Wound Healing

Advanced Materials, Год журнала: 2023, Номер 35(31)

Опубликована: Июнь 7, 2023

Abstract Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria‐infected open wounds with conventional measures is problematic. Here, photothermal cascade nano‐reactor (CPNC@GOx‐Fe 2+ ) constructed through supramolecular strategy hydrogen bonding coordination interactions between chitosan‐modified palladium nano‐cube (CPNC), glucose oxidase (GOx), ferrous iron (Fe ). CPNC@GOx‐Fe exhibits excellent effects powers GOx‐assisted reaction generate hydroxyl radicals, enabling chemodynamic combination therapy against biofilms. Further proteomics, metabolomics, all‐atom simulation results indicate that damage radical function structure cell membrane thermal enhance fluidity inhomogeneity bacterial membrane, resulting synergistic antibacterial effect. In biofilm‐associated tooth extraction wound model, generated from process can initiate polymerization form hydrogel situ protection. vivo experiments confirm protection accelerate healing infected tooth‐extraction without affecting oral commensal microbiota. This study provides way propose multifunctional system treatment infection.

Язык: Английский

---

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

---

Mild Photothermal‐Stimulation Based on Injectable and Photocurable Hydrogels Orchestrates Immunomodulation and Osteogenesis for High‐Performance Bone Regeneration

Small, Год журнала: 2023, Номер 19(28)

Опубликована: Май 16, 2023

Abstract A photoactivated bone scaffold integrated with minimally invasive implantation and mild thermal‐stimulation capability shows great promise in the repair regeneration of irregularly damaged tissues. Developing multifunctional photothermal biomaterials that can simultaneously serve as both controllable thermal stimulators biodegradable engineering scaffolds for immunomodulation, infection therapy, impaired remains an enormous challenge. Herein, injectable photocurable hydrogel therapeutic platform (AMAD/MP) based on alginate methacrylate, alginate‐graft‐dopamine, polydopamine (PDA)‐functionalized Ti3C2 MXene (MXene@PDA) nanosheets is rationally designed near‐infrared (NIR)‐mediated synergistic osteogenesis, bacterial elimination. The optimized AMAD/MP exhibits favorable biocompatibility, osteogenic activity, immunomodulatory functions vitro. proper immune microenvironment provided by could further modulate balance M1/M2 phenotypes macrophages, thereby suppressing reactive oxygen species‐induced inflammatory status. Significantly, this stimulation efficiently attenuates local reactions promotes new formation without addition exogenous cells, cytokines, or growth factors. This work highlights potential application advanced providing on‐demand cues tissue regenerative medicine.

Язык: Английский

---