Injectable Self-Healing Adhesive Chitosan Hydrogel with Antioxidative, Antibacterial, and Hemostatic Activities for Rapid Hemostasis and Skin Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(30), С. 34455 - 34469

Опубликована: Июль 20, 2022

Engineered wound dressing materials with excellent injectability, self-healing ability, tissue-adhesiveness, especially the ones possessing potential therapeutic effects have great practical significance in healthcare. Herein, an injectable quaternary ammonium chitosan (QCS)/tannic acid (TA) hydrogel based on QCS and TA was designed fabricated by facile mixing of two ingredients under physiological conditions. In this system, hydrogels were mainly cross-linked dynamic ionic bonds hydrogen between TA, which endows injectable, self-healing, adhesive properties. Benefitting from inherent antioxidative, antibacterial, hemostatic abilities QCS, showed superior reactive oxygen species scavenging activity, broad-spectrum antibacterial as well rapid capability. Moreover, QCS/TA2.5 (containing 2.5% TA) exhibited biocompatibility. The vivo experiments also that not only rapidly stopped bleeding arterial deep incompressible wounds mouse tail amputation, femoral artery hemorrhage, liver incision models but significantly accelerated healing a full-thickness skin model. For potentials listed above, multifunctional offers promising network material for both hemostasis repair.

Язык: Английский

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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Advanced Science, Год журнала: 2023, Номер 10(28)

Опубликована: Авг. 6, 2023

Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.

Язык: Английский

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Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

Advanced Science, Год журнала: 2023, Номер 10(11)

Опубликована: Фев. 12, 2023

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant

Язык: Английский

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Immunoregulatory hydrogel decorated with Tannic acid/Ferric ion accelerates diabetic wound healing via regulating Macrophage polarization

Chemical Engineering Journal, Год журнала: 2023, Номер 466, С. 143173 - 143173

Опубликована: Апрель 24, 2023

Язык: Английский

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Multifunctional hydrogel with reactive oxygen species scavenging and photothermal antibacterial activity accelerates infected diabetic wound healing

Acta Biomaterialia, Год журнала: 2022, Номер 155, С. 199 - 217

Опубликована: Ноя. 17, 2022

Язык: Английский

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Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing

Carbohydrate Polymers, Год журнала: 2023, Номер 312, С. 120824 - 120824

Опубликована: Март 20, 2023

Язык: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Год журнала: 2022, Номер 299, С. 120228 - 120228

Опубликована: Окт. 14, 2022

Язык: Английский

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Construction and function of robust and moist bilayer chitosan-based hydrogel wound dressing

Materials & Design, Год журнала: 2023, Номер 226, С. 111604 - 111604

Опубликована: Янв. 6, 2023

The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan polyacrylamide double network (C-A) chosen a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer designed to cover surface, interfacial reaction happens link two layers tightly for achieving function synergy. In this double-layer (DH) dressing, surface P-A with strong locking ability could keep moist long time, high strength toughness make maintain integrity under large deformation stress strengthen protection, C-A modest adhesion ensures fit skin, synergistic swelling guarantee fast absorption exudate. Moreover, in vitro vivo tests, DH exhibits excellent antibacterial cytocompatibility, it significantly accelerate tissue regeneration closure than commercial hydrocolloid dressings. general, easy prepare shows superior comprehensive performance, revealing great potential use independently applied dressing.

Язык: Английский

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Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair

Carbohydrate Polymers, Год журнала: 2023, Номер 305, С. 120545 - 120545

Опубликована: Янв. 7, 2023

Язык: Английский

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An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects

Nano Today, Год журнала: 2023, Номер 49, С. 101801 - 101801

Опубликована: Март 1, 2023

Язык: Английский

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