Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
An uncomplicated template method was employed to produce sulfur vacancies (V S )-doped hollow Co 9 8 nanocages (Co 8− x ) endow a single-component nanomaterial with simultaneous catalytic activity and NIR-II photothermal property.
Язык: Английский
Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(5), С. 370 - 388
Опубликована: Март 14, 2024
Язык: Английский
Процитировано
128
Advanced Materials, Год журнала: 2024, Номер 36(25)
Опубликована: Март 16, 2024
The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd
Язык: Английский
Процитировано
53
Advanced Materials, Год журнала: 2024, Номер 36(30)
Опубликована: Май 4, 2024
Abstract Low efficacy of immunotherapy due to the poor immunogenicity most tumors and their insufficient infiltration by immune cells highlights importance inducing immunogenic cell death activating system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed engineered ferroelectricity‐enhanced apoptosis, cuproptosis, subsequently evoked immunotherapy. In this structure, suppressed recombination electron–hole pairs band bending polarization lead high catalytic activity, triggering reactive oxygen species bursts apoptosis. The fragments produced apoptosis serve as antigens activate T cells. Moreover, generated charge catalysis, nanomedicine can act “a smart switch” open membrane, promote nanomaterial endocytosis, shut down + outflow pathway evoke thus a strong response is triggered reduced content adenosine triphosphate. Ribonucleic acid transcription tests reveal pathways related activation. Thus, study firstly demonstrates feasible strategy enhancing using single semiconductor‐induced cuproptosis.
Язык: Английский
Процитировано
42
Nanoscale, Год журнала: 2024, Номер 16(9), С. 4434 - 4483
Опубликована: Янв. 1, 2024
Metal-organic frameworks have become promising stimuli-responsive agents to release the loaded therapeutic in target site achieve more precise drug delivery due their high loading, excellent biocompatibility, and stimuli-responsiveness.
Язык: Английский
Процитировано
34
Advanced Materials, Год журнала: 2024, Номер 36(27)
Опубликована: Март 29, 2024
Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.
Язык: Английский
Процитировано
27
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 14, 2024
Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.
Язык: Английский
Процитировано
20
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 3, 2024
Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (
Язык: Английский
Процитировано
16
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Фев. 28, 2024
Abstract The insufficient exposure sites and active site competition of multienzyme are the two main factors to hinder its therapeutic effect. Here, a phase‐junction nanomaterial (amorphous‐crystalline Cu x S–Ag 2 S) is designed prepared through simple room temperature ion‐exchange process. A small amount Ag + added into 7 S 4 nanocrystals, which transforms amorphous phased produces crystalline simultaneously. In this structure, overhanging bonds on surface provide abundant for optimizing activity. Meanwhile, state enhances photothermal effect non‐radiative relaxation, due low thermal resistance, forms significant gradient unlock optimized thermo‐electrodynamic therapy. Furthermore, benefiting from high asymmetry state, material spin‐polarized that can effectively inhibit electron–hole recombination. way, thermoelectric facilitate enzyme‐catalyzed cycle by providing electrons holes, enabling an enhanced coupling therapy with activity, induces excellent anti‐tumor performance. More importantly, catalytic process simulated density‐functional theory proves alleviates burden favorable adsorption O prevents competition.
Язык: Английский
Процитировано
15
Advanced Materials, Год журнала: 2024, Номер 36(48)
Опубликована: Окт. 13, 2024
Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO
Язык: Английский
Процитировано
14
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Янв. 23, 2024
Nanozyme-based metabolic regulation triggered by tumor-specific endogenous stimuli has emerged as a promising therapeutic strategy for tumors. The current efficacy, however, is constrained the limited concentration of substrates and plasticity Consequently, implementation efficient in tumor therapy urgently needed. Herein, versatile nanozyme-based nicotinamide adenine dinucleotide (NADH) circulating oxidation nanoreactor reported. First, synthesized cobalt-doped hollow carbon spheres (Co-HCS) possess NADH oxidase (NOX)-mimicking activity to disrupt oxidative phosphorylation (OXPHOS) pathway cells. Second, substrate-cycle manner Co-HCS can be used overcome limitation substrate deficiency. Finally, 2-Deoxy-D-glucose (2-DG) 6-aminonicotinamide (6-AN) are introduced block glycolysis pentose phosphate (PPP), thus creating (Co-HCS/D/A) through triple cellular metabolism disruption. In vitro vivo results demonstrate that designed not only enhances catalytic efficiency but also disrupts homeostasis, leading outcome. This study develops novel disruption, which addresses limitations therapy.
Язык: Английский
Процитировано
11