Progress in and promise of bacterial quorum sensing research

Nature, Год журнала: 2017, Номер 551(7680), С. 313 - 320

Опубликована: Ноя. 14, 2017

Язык: Английский

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Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

PLoS Biology, Год журнала: 2015, Номер 13(8), С. e1002226 - e1002226

Опубликована: Авг. 18, 2015

Groundbreaking research on the universality and diversity of microorganisms is now challenging life sciences to upgrade fundamental theories that once seemed untouchable. To fully appreciate change field undergoing, one has place epochs foundational principles Darwin, Mendel, modern synthesis in light current advances are enabling a new vision for central importance microbiology. Animals plants no longer heralded as autonomous entities but rather biomolecular networks composed host plus its associated microbes, i.e., "holobionts." As such, their collective genomes forge "hologenome," models animal plant biology do not account these intergenomic associations incomplete. Here, we integrate concepts into historical contemporary visions summarize predictive refutable framework evaluation. Specifically, present ten clarify append what not, explain how they both support extend existing theory sciences, discuss potential ramifications multifaceted approaches zoology botany. We anticipate conceptual evidence-based foundation provided this essay will serve roadmap hypothesis-driven, experimentally validated holobionts hologenomes, thereby catalyzing continued fusion biology's subdisciplines. At time when symbiotic microbes recognized all aspects biology, holobiont hologenome afford holistic view biological complexity consistent with generally reductionist biology.

Язык: Английский

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Gut Microbiotas and Host Evolution: Scaling Up Symbiosis

Trends in Ecology & Evolution, Год журнала: 2016, Номер 31(7), С. 539 - 549

Опубликована: Март 31, 2016

Язык: Английский

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Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

Natural Product Reports, Год журнала: 2015, Номер 32(7), С. 904 - 936

Опубликована: Янв. 1, 2015

Many organisms team up with symbiotic microbes for defense against predators, parasites, parasitoids, or pathogens. Here we review the known defensive symbioses in animals and microbial secondary metabolites responsible providing protection to host.

Язык: Английский

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Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts

mBio, Год журнала: 2016, Номер 7(2)

Опубликована: Апрель 1, 2016

The advent of relatively inexpensive tools for characterizing microbial communities has led to an explosion research exploring the diversity, ecology, and evolution microbe-host systems. Some now question whether existing conceptual frameworks are adequate explain One popular paradigm is "holobiont-hologenome," which argues that a host its microbiome evolve as single cooperative unit selection (i.e., superorganism). We argue hologenome based on overly restrictive assumptions render it approach little utility. A plus more effectively viewed ecological community organisms encompasses broad range interactions (parasitic mutualistic), patterns transmission (horizontal vertical), levels fidelity among partners. requires high partner if unit. However, even when this achieved by particular host-microbe pairs, unlikely hold entire microbiome, therefore hologenome. Both mutualistic antagonistic (fitness conflict) can occur constituent members community, not just adaptations at "hologenome" level, there abundant empirical evidence such divergence selective interests host-microbiome communities. believe concepts methods genetics, evolutionary biology will continue provide well-grounded intellectual framework researching communities, without recourse limiting assumption acts predominantly holobiont level.

Язык: Английский

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Microbiomes as sources of emergent host phenotypes

Science, Год журнала: 2019, Номер 365(6460), С. 1405 - 1409

Опубликована: Сен. 26, 2019

Microbial communities associated with animals exert powerful influences on host physiology, regulating metabolism and immune function, as well complex behaviors. The importance of host–microbiome interactions for maintaining homeostasis promoting health raises evolutionarily complicated questions about how their microbiomes have coevolved, these relationships affect the ways that interact environment. Here, we review literature contributions factors to microbial community structure corresponding emergent phenotypes. We focus in particular animal behaviors a basis understanding potential roles microbiome shaping neurobiology.

Язык: Английский

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Ecological Developmental Biology

Encyclopedia of Life Sciences, Год журнала: 2017, Номер unknown, С. 1 - 8

Опубликована: Янв. 16, 2017

Abstract Ecological developmental biology is the science that studies interactions between developing organisms and their environmental contexts. It development in ‘real world’ of predators, competitors, symbionts, toxic compounds, temperature changes nutritional differences. The environment plays a substantial role development, many instances, normal cannot occur without signalling. Symbionts, for instance are needed particular organs. Environmental agents can elicit epigenetic gene expression change an organism's phenotype. In however, substances act detrimentally, causing birth defects predisposing organism to diseases adulthood. Epigenetics has recently provided startling insights into how experienced during embryonic predispose one cancer, obesity, hypertension diabetes later life. Key Concepts critical roles development. genome encodes repertoire possible phenotypes. Environment often selects which those genes will become active phenotypes expressed. Reaction norms quantitatively respond conditions, such phenotype reflects small differences conditions. Polyphenisms represent ‘either/or’ wherein set conditions elicits phenotype, while another Organisms usually develop symbiotic relationships with other organisms; signals from symbionts Teratogens (such as ethanol) compounds cause by disrupting Endocrine disruptors disrupt changing ways not seen phenotypically years after birth. proposes new mechanisms through evolution occur. These include epialleles (inherited patterns chromatin alterations giving inherited variants patterns), plasticity‐driven adaptation symbiont‐mediated variation.

Язык: Английский

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Microbial Dysbiosis: Rethinking Disease in Marine Ecosystems

Frontiers in Microbiology, Год журнала: 2016, Номер 7

Опубликована: Июнь 21, 2016

With growing environmental pressures placed on our marine habitats there is concern that the prevalence and severity of diseases affecting organisms will increase. Yet relative to terrestrial systems, we know little about underlying causes many these diseases. Moreover, factors such as saprophytic colonizers a lack baseline data healthy individuals make it difficult accurately assess role specific microbial pathogens in disease states. Emerging evidence field medicine suggests number human result from microbiome imbalance (or dysbiosis), questioning traditional view singular pathogenic agent. Here discuss possibility seen systems are, similarly, dysbiosis rise opportunistic or polymicrobial infections. Thus, understanding managing future require us also rethink definitions pathogenesis for systems. We suggest targeted, multidisciplinary approach addresses questions symbiosis both diseased states, at level holobiont, be key progress this area.

Язык: Английский

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Microbial evolution and transitions along the parasite–mutualist continuum

Nature Reviews Microbiology, Год журнала: 2021, Номер 19(10), С. 623 - 638

Опубликована: Апрель 19, 2021

Virtually all plants and animals, including humans, are home to symbiotic microorganisms. Symbiotic interactions can be neutral, harmful or have beneficial effects on the host organism. However, growing evidence suggests that microbial symbionts evolve rapidly, resulting in drastic transitions along parasite–mutualist continuum. In this Review, we integrate theoretical empirical findings discuss mechanisms underpinning these evolutionary shifts, as well ecological drivers why some host–microorganism may stuck at end of addition having biomedical consequences, understanding dynamic life microorganisms reveals how symbioses shape an organism's biology entire community, particularly a changing world. for organisms. Drew, Stevens King continuum, underlying changes, selective pressures involved common approaches studying them.

Язык: Английский

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CeMbio - TheCaenorhabditis elegansMicrobiome Resource

G3 Genes Genomes Genetics, Год журнала: 2020, Номер 10(9), С. 3025 - 3039

Опубликована: Июль 16, 2020

The study of microbiomes by sequencing has revealed a plethora correlations between microbial community composition and various life-history characteristics the corresponding host species. However, inferring causation from correlation is often hampered sheer compositional complexity microbiomes, even in simple organisms. Synthetic communities offer an effective approach to infer cause-effect relationships host-microbiome systems. Yet available suffer several drawbacks, such as artificial (thus non-natural) choice microbes, microbe-host mismatch (

Язык: Английский

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