Ageing Research Reviews,
Год журнала:
2023,
Номер
92, С. 102094 - 102094
Опубликована: Окт. 18, 2023
As
a
global
public
health
problem,
low
back
pain
(LBP)
caused
by
intervertebral
disc
degeneration
(IDD)
seriously
affects
patients'
quality
of
life.
In
addition,
the
prevalence
IDD
tends
to
be
younger,
which
brings
huge
burden
individuals
and
society
economically.
Current
treatments
do
not
delay
or
reverse
progression
IDD.
The
emergence
biologic
therapies
has
brought
new
hope
for
treatment
Among
them,
extracellular
vesicles
(EVs),
as
nanoscale
bioactive
substances
that
mediate
cellular
communication,
have
now
produced
many
surprising
results
in
research
This
article
reviews
mechanisms
roles
EVs
delaying
describes
prospects
challenges
EVs.
Intervertebral
disc
degeneration
(IVDD)-induced
lower
back
pain
(LBP)
is
a
common
problem
worldwide.
The
underlying
mechanism
partially
accredited
to
ferroptosis,
based
on
sequencing
analyses
of
IVDD
patients
from
the
gene
expression
omnibus
(GEO)
databases.
In
this
study,
it
shown
that
polydopamine
nanoparticles
(PDA
NPs)
inhibit
oxidative
stress-induced
ferroptosis
in
nucleus
pulposus
(NP)
cells
vitro.
PDA
NPs
scavenge
reactive
oxygen
species
(ROS),
chelate
Fe
Abstract
Preventing
and
treating
avascular
necrosis
at
the
distal
end
of
flaps
are
critical
to
surgery
success,
but
current
treatments
not
ideal.
A
recent
study
shows
that
apoptotic
bodies
(ABs)
generated
near
site
apoptosis
can
be
taken
up
promote
cell
proliferation.
The
reveals
ABs
derived
from
fibroblast‐like
cells
in
subcutaneous
connective
tissue
(FSCT
cells)
skin
promoted
ischaemic
flap
survival.
It
is
also
found
inhibited
death
oxidative
stress
M1‐to‐M2
polarization
macrophages.
Transcriptome
sequencing
protein
level
testing
demonstrated
survival
endothelial
macrophages
by
inhibiting
ferroptosis
via
KEAP1‐Nrf2
axis.
Furthermore,
microRNA
(miR)
data
vitro
vivo
experiments
KEAP1
delivering
miR‐339‐5p
exert
therapeutic
effects.
In
conclusion,
FSCT
cell‐derived
ferroptosis,
macrophage
transition
miR‐339‐5p/KEAP1/Nrf2
axis
These
results
provide
a
potential
strategy
administering
ABs.
Experimental Gerontology,
Год журнала:
2023,
Номер
177, С. 112181 - 112181
Опубликована: Апрель 24, 2023
Intervertebral
disc
degeneration
(IDD)
is
the
leading
cause
of
low
back
pain
(LBP)
and
disability
in
elderly,
imposing
significant
public
health
economic
burden
worldwide.
Meanwhile,
pathological
mechanisms
IDD
remain
complicated,
treatment
strategy
to
reverse
primarily
due
unclear
specific
lack
particular
effective
targets.
Interleukin-1β
(IL-1β),
one
most
important
members
IL-1
family,
can
induce
solid
pro-inflammatory
activity
by
stimulating
secretion
various
mediators
considered
key
mediator.
However,
recent
years,
IL-1β
be
able
regulate
IVD
cell
death
many
ways,
such
as
apoptosis,
pyroptosis,
ferroptosis,
so
on.
At
same
time,
numerous
studies
on
inhibitors
suggest
that
inhibition
may
a
promising
biological
therapy
for
IDD.
Many
have
been
investigated
through
pathogenic
mechanisms,
including
inhibiting
inflammatory
processes,
regulating
ECM
degradation,
more.
Therefore,
anti-IL-1β
effect
alleviating
degeneration.
This
article
mainly
reviews
functions
investigates
advances
biotherapeutic
approach
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Июль 27, 2023
Nucleus
pulposus,
annulus
fibrosus,
and
cartilage
endplate
constitute
an
avascular
intervertebral
disc
(IVD),
which
is
crucial
for
spinal
joint
mobility.
As
one
of
the
most
widespread
health
issues
worldwide,
degeneration
(IVDD)
recognized
as
a
key
contributor
to
back
neck
discomfort.
A
number
degenerative
disorders
have
strong
correlation
with
ferroptosis,
recently
identified
novel
regulated
cell
death
(RCD)
characterized
by
iron-dependent
mechanism
buildup
lipid
reactive
oxygen
species
(ROS).
There
growing
interest
in
part
ferroptosis
plays
IVDD
pathophysiology.
Inhibiting
has
been
shown
control
development.
Several
studies
demonstrated
that
TBHP-induced
oxidative
stress
models,
changes
marker
protein
levels
increased
peroxidation
lead
cells,
subsequently
aggravates
IVDD.
Similarly,
significantly
relieved
use
inhibitors.
The
purpose
this
review
was
threefold:
1)
discuss
occurrence
IVDD;
2)
understand
its
role
pathophysiology;
3)
investigate
feasibility
prospect
treatment.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25251 - e25251
Опубликована: Фев. 1, 2024
This
review
discusses
recent
experimental
and
clinical
findings
related
to
ferroptosis,
with
a
focus
on
the
role
of
MSCs.
Therapeutic
efficacy
current
applications
MSC-based
ferroptosis
therapies
are
also
discussed.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 2, 2024
Abstract
Exosomes
are
nano-sized
membrane
extracellular
vesicles
which
can
be
released
from
various
types
of
cells.
originating
inflammatory
or
injured
cells
have
detrimental
effects
on
recipient
cells,
while
exosomes
derived
stem
not
only
facilitate
the
repair
and
regeneration
damaged
tissues
but
also
inhibit
inflammation
provide
protective
against
diseases,
suggesting
they
may
serve
as
an
alternative
strategy
transplantation.
a
fundamental
role
in
communication
between
through
transfer
proteins,
bioactive
lipids
nucleic
acids
(like
miRNAs
mRNAs)
This
significantly
impacts
both
physiological
pathological
functions
Nuclear
factor
erythroid
2–related
2
(Nrf2),
transcription
factor,
is
able
to
mitigate
damage
caused
by
oxidative
stress
signaling
pathways.
The
positive
resulting
activation
Nrf2
pathway
different
disorders
been
documented
literature.
Studies
confirmed
that
could
act
effective
agonists.
However,
limited
studies
explored
therapeutic
cell-derived
exosomes.
review
provides
comprehensive
overview
existing
knowledge
concerning
pathways
impact
exerted
cell
some
common
diseases.
Graphical
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 10, 2024
This
comprehensive
review
inspects
the
therapeutic
potential
of
mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
across
multiple
organ
systems.
Examining
their
impact
on
integumentary,
respiratory,
cardiovascular,
urinary,
and
skeletal
systems,
study
highlights
versatility
MSC-EVs
in
addressing
diverse
medical
conditions.
Key
pathways,
such
as
Nrf2/HO-1,
consistently
emerge
central
mediators
antioxidative
anti-inflammatory
effects.
From
expediting
diabetic
wound
healing
to
mitigating
oxidative
stress-induced
skin
injuries,
alleviating
acute
lung
even
offering
solutions
for
conditions
like
myocardial
infarction
renal
ischemia-reperfusion
injury,
demonstrate
promising
efficacy.
Their
adaptability
different
administration
routes
identifying
specific
factors
opens
avenues
innovative
regenerative
strategies.
positions
candidates
future
clinical
applications,
providing
a
overview
medicine.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Окт. 7, 2022
Intervertebral
disc
degeneration
(IVDD)
is
a
main
cause
of
lower
back
pain,
leading
to
psychological
and
economic
burdens
patients.
Physical
therapy
only
delays
pain
in
patients
but
cannot
eliminate
the
IVDD.
Surgery
required
when
patient
tolerate
or
has
severe
neurological
symptoms.
Although
surgical
resection
IVD
decompression
laminae
eliminates
diseased
segment,
it
damages
adjacent
normal
IVD.
There
also
risk
re-protrusion
after
removal.
Cell
played
crucial
role
development
regenerative
medicine.
transplantation
promotes
regeneration
degenerative
tissue.
However,
owing
lack
vascular
structure
IVD,
sufficient
nutrients
be
provided
for
transplanted
mesenchymal
stem
cells
(MSCs).
In
addition,
dead
release
harmful
substances
that
aggravate
Extracellular
vesicles
(EVs)
have
been
extensively
studied
as
an
emerging
therapeutic
approach.
EVs
generated
by
paracrine
MSCs
retain
potential
serve
carriers
deliver
their
contents
target
regulate
cell
activity.
Owing
double-layered
membrane
structure,
low
immunogenicity
no
immune
rejection.
Therefore,
are
considered
modality
they
limited
mass
production
loading
rates.
this
review,
advantages
introduced,
application
MSC-EVs
IVDD
discussed.
The
current
limitations
future
applications
described.
