Trends in Immunology, Год журнала: 2023, Номер 44(11), С. 868 - 870
Опубликована: Окт. 6, 2023
Язык: Английский
Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(9), С. 583 - 603
Опубликована: Июнь 26, 2023
Язык: Английский
Процитировано
71
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июнь 18, 2024
Abstract Tumorigenesis is a multistep process, with oncogenic mutations in normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic and expansion tissues, their transformation into cancer remains rare event, indicating presence of additional driver events for progression to an irreversible, highly heterogeneous, invasive lesion. Recently, researchers are emphasizing mechanisms environmental tumor risk factors epigenetic alterations that profoundly influencing early malignant evolution, independently inducing mutations. Additionally, evolution tumorigenesis reflects multifaceted interplay between cell-intrinsic identities various cell-extrinsic exert selective pressures either restrain uncontrolled proliferation or allow specific clones progress tumors. by which induce both intrinsic cellular competency remodel stress facilitate not fully understood. In this review, we summarize genetic, epigenetic, external events, effects on co-evolution transformed cells ecosystem during initiation evolution. A deeper understanding earliest molecular holds promise translational applications, predicting individuals at high-risk developing strategies intercept transformation.
Язык: Английский
Процитировано
55
Nature Medicine, Год журнала: 2024, Номер 30(3), С. 785 - 796
Опубликована: Фев. 16, 2024
Abstract Multiple clinical trials targeting the gut microbiome are being conducted to optimize treatment outcomes for immune checkpoint blockade (ICB). To improve success of these interventions, understanding changes during ICB is urgently needed. Here through longitudinal profiling 175 patients treated with advanced melanoma, we show that several microbial species-level genome bins (SGBs) and pathways exhibit distinct patterns from baseline in achieving progression-free survival (PFS) 12 months or longer (PFS ≥12) versus PFS shorter than <12). Out 99 SGBs could discriminate between two groups, 20 were differentially abundant only at baseline, while 42 after initiation. We identify five four had consistently higher abundances ≥12 <12 months, respectively. Constructing a log ratio SGBs, find an association overall survival. Finally, different dynamics contexts including type regimen, development immune-related adverse events concomitant medication use. Insights into host factors regimens will be critical guiding rational microbiome-targeted therapies aimed enhancing efficacy.
Язык: Английский
Процитировано
50
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Май 18, 2024
Abstract Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis aging coincide because both are driven by time, irrespective of the precise causes, can be confronted with idea share common mechanistic grounds referred to as ‘hallmarks’. Indeed, several hallmarks also contribute carcinogenesis tumor progression, but some molecular cellular characteristics may reduce probability developing lethal cancer, perhaps explaining why very old age (> 90 years) is accompanied a reduced incidence neoplastic diseases. We discuss possibility process itself causes meaning time-dependent degradation supracellular functions accompanies produces byproduct or ‘age-associated disease’. Conversely, its treatment erode health drive process, has dramatically been documented for survivors diagnosed during childhood, adolescence, young adulthood. conclude connected superior including endogenous lifestyle factors, well bidirectional crosstalk, together render not only risk factor an important parameter must considered therapeutic decisions.
Язык: Английский
Процитировано
43
Nature Medicine, Год журнала: 2023, Номер 29(1), С. 59 - 74
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
35
Antioxidants, Год журнала: 2023, Номер 12(2), С. 428 - 428
Опубликована: Фев. 9, 2023
Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies
Язык: Английский
Процитировано
24
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Язык: Английский
Процитировано
13
Cellular and Molecular Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction patients are refractory to ICIs employed as standalone therapeutics, necessitating development combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest partners for ICIs, at least in part owing their ability initiate tumor-targeting adaptive response. However, compared either approach alone, regimens involving ICD and not always shown superior activity. Here, we discuss accumulating evidence on therapeutic interactions between oncological settings, identify key factors that may explain discrepancies preclinical findings, propose strategies address existing challenges increase efficacy these combinations cancer.
Язык: Английский
Процитировано
8
Water, Год журнала: 2024, Номер 16(19), С. 2710 - 2710
Опубликована: Сен. 24, 2024
Microalgae-based wastewater bioremediation has emerged as a promising and sustainable solution for water purification by harnessing the natural ability of microalgae to absorb transform pollutants. In literature, it is possible find diverse applications in treatment, highlighting their efficiency nutrient removal, heavy metal sequestration, overall quality enhancement. Although demonstrate remarkable potential there critical gap research concerning utilization biomass produced during treatment process, including large-scale harvesting methods, economic viability assessments, exploration innovative downstream applications. By shedding light on these deficiencies, aim this review encourage further development maximize removing pollution application derived from treatment. conclusion, not only underscores but also emphasizes necessity more comprehensive approach that considers full lifecycle microalgae, biomass, addressing both environmental concerns.
Язык: Английский
Процитировано
7
Cancers, Год журнала: 2022, Номер 14(21), С. 5402 - 5402
Опубликована: Ноя. 2, 2022
Multidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality life. Its impact important on factors that control tumor development, such immune system, inflammation, tissue perfusion, hypoxia, insulin resistance, metabolism, glucocorticoid levels, cachexia. An increasing amount research has been published in last years effects physical activity within framework oncology, marking appearance medical field, commonly known “exercise oncology”. This emerging field trying determine biological mechanisms by which, aerobic affects incidence cancer, progression and/or metastases. We propose an overview current state art interventions management cancer patients, including pragmatic perspective with tips for routine practice. then develop mechanistic views about their potential clinical applications. Moving toward more personalized, integrated, patient-centered, multidisciplinary management, understand different interactions between host, well disease treatments organs, this seems be most promising method care patients.
Язык: Английский
Процитировано
23