Engineered Regeneration,
Год журнала:
2022,
Номер
4(1), С. 55 - 67
Опубликована: Дек. 2, 2022
Lung
cancer
has
become
one
of
the
key
life-threatening
factors
and
is
most
common
type
tumor.
With
improvement
equipment
lung
awareness,
surgical
treatment
becoming
more
mature.
Surgery
can
provide
an
important
part
individualized
strategies
for
patients
with
different
stages
wishes.
In
addition,
concept
minimally
invasive,
precise,
intelligent
triggered
a
revolutionary
change
in
strategy
cancer.
Therefore,
this
review
focuses
on
development
surgery
history,
summarizing
era
from
traditional
to
invasive
thoracic
based
TV-assisted
surgery.
The
operating
methods
effects
are
comprehensively
introduced,
optimization
future
also
discussed.
Along
techniques,
there
explorations
nanotechnology
application
imaging,
combination
nanomedicine
effective
solution
today.
So,
summarizes
prospects
before,
during
after
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Май 4, 2023
Abstract
Pulmonary
fibrosis
results
from
dysregulated
lung
repair
and
involves
multiple
cell
types.
The
role
of
endothelial
cells
(EC)
in
is
poorly
understood.
Using
single
RNA-sequencing
we
identified
transcription
factors
involved
fibrogenesis,
including
FOXF1,
SMAD6,
ETV6
LEF1.
Focusing
on
found
that
FOXF1
decreased
EC
within
human
idiopathic
pulmonary
(IPF)
mouse
bleomycin-injured
lungs.
Endothelial-specific
Foxf1
inhibition
mice
increased
collagen
depositions,
promoted
inflammation,
impaired
R-Ras
signaling.
In
vitro,
FOXF1-deficient
proliferation,
invasion
activation
fibroblasts,
stimulated
macrophage
migration
by
secreting
IL-6,
TNFα,
CCL2
CXCL1.
inhibited
TNFα
through
direct
transcriptional
Rras
gene
promoter.
Transgenic
overexpression
or
endothelial-specific
nanoparticle
delivery
cDNA
mice.
Nanoparticle
can
be
considered
for
future
therapies
IPF.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(8), С. 1059 - 1059
Опубликована: Авг. 12, 2024
Inhaled
nanoparticle
(NP)
therapy
poses
intricate
challenges
in
clinical
and
pharmacodynamic
realms.
Recent
strides
have
revolutionized
NP
technology
by
enabling
the
incorporation
of
diverse
molecules,
thus
circumventing
systemic
clearance
mechanisms
enhancing
drug
effectiveness
while
mitigating
side
effects.
Despite
established
success
delivery
oncology
other
disciplines,
exploration
inhaled
therapies
remains
relatively
nascent.
NPs
loaded
with
bronchodilators
or
anti-inflammatory
agents
exhibit
promising
potential
for
precise
distribution
throughout
bronchial
tree,
offering
targeted
treatment
respiratory
diseases.
This
article
conducts
a
comprehensive
review
applications
medicine,
highlighting
their
merits,
ranging
from
heightened
stability
to
exacting
lung-specific
delivery.
It
also
explores
cutting-edge
technologies
optimizing
NP-loaded
aerosol
systems,
complemented
insights
gleaned
trials.
Furthermore,
examines
current
future
prospects
NP-based
therapies.
By
synthesizing
data
perspectives,
underscores
transformative
promise
NP-mediated
addressing
chronic
conditions
such
as
obstructive
pulmonary
disease,
pressing
global
health
concern
ranked
third
mortality
rates.
overview
illuminates
evolving
landscape
inhalation
therapies,
presenting
optimistic
avenues
advancing
medicine
improving
patient
outcomes.
European Journal of Medicinal Chemistry Reports,
Год журнала:
2024,
Номер
12, С. 100184 - 100184
Опубликована: Июнь 26, 2024
Polyphenol
is
a
versatile
green
phytochemical
vital
in
several
biomedical
applications
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
emergence
of
novel
nanotechnology
techniques,
such
as
electrospinning,
has
proven
to
be
an
excellent
option
for
nanotechnology,
ensuring
effective
drug
delivery
system
recognised
medicinal
plant
extracts
containing
polyphenols
electrospun
nanofibers
can
provide
the
necessary
environment
encapsulation.
Together,
have
shown
promising
usage
wound
healing.
When
are
incorporated
into
nanofibrous
scaffolds,
their
combined
properties
enhance
cell
attachment,
proliferation,
differentiation.
This
review
explores
potential
polyphenol-loaded
therapy,
highlighting
importance
efficient
systems
polyphenols.
It
provides
brief
assessment
specific
(resveratrol,
curcumin,
thymol,
quercetin,
tannic
acid,
ferulic
hesperidin,
gallic
kaempferol,
chlorogenic
acid)
that
been
successfully
encapsulated
applied
treatment.
Despite
ongoing
research,
certain
carvacrol,
oleuropein,
kaempferol
remain
less
explored.
underscores
need
continued
investigation
these
while
recognising
growing
application
healing
more
extensive
therapeutic
use.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(8)
Опубликована: Ноя. 20, 2023
Abstract
Most
nanomedicines
require
efficient
in
vivo
delivery
to
elicit
meaningful
diagnostic
and
therapeutic
effects.
However,
en
route
their
intended
tissues,
systemically
administered
nanoparticles
often
encounter
barriers.
To
describe
these
barriers,
the
term
“nanoparticle
blood
removal
pathways”
(NBRP)
is
proposed,
which
summarizes
interactions
between
body's
various
cell‐dependent
cell‐independent
clearance
mechanisms.
Nanoparticle
design
biological
modulation
strategies
are
reviewed
mitigate
nanoparticle‐NBRP
interactions.
As
affect
nanoparticle
delivery,
preclinical
literature
from
2011–2021
studied,
circulation
organ
biodistribution
data
analyzed.
The
findings
reveal
that
surface
chemistry
affects
behavior
more
than
other
parameters.
Combinatory
biological‐PEG
modification
improves
area
under
curve
by
≈418%,
with
a
decrease
liver
accumulation
of
up
47%.
A
greater
understanding
associated
trends
will
provide
new
for
safer,
effective,
nanomedicines.
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Сен. 28, 2023
The
use
of
biomaterials
in
delivering
CRISPR/Cas9
for
gene
therapy
infectious
diseases
holds
tremendous
potential.
This
innovative
approach
combines
the
advantages
with
protective
properties
biomaterials,
enabling
accurate
and
efficient
editing
while
enhancing
safety.
Biomaterials
play
a
vital
role
shielding
components,
such
as
lipid
nanoparticles
or
viral
vectors,
from
immunological
processes
degradation,
extending
their
effectiveness.
By
utilizing
flexibility
tailored
systems
can
be
designed
to
address
specific
genetic
diseases,
paving
way
personalized
therapeutics.
Furthermore,
this
delivery
method
offers
promising
avenues
combating
illnesses
by
precisely
modifying
pathogen
genomes,
reducing
pathogenicity.
facilitate
site-specific
modifications,
ensuring
effective
infected
cells
minimizing
off-target
effects.
However,
challenges
remain,
including
optimizing
efficiency,
effects,
long-term
safety,
establishing
scalable
production
techniques.
Thorough
research,
pre-clinical
investigations,
rigorous
safety
evaluations
are
imperative
successful
translation
laboratory
clinical
applications.
In
review,
we
discussed
how
using
revolutionizes
disease
treatment,
offering
precise
safe
capabilities
potential
significantly
improve
human
health
quality
life.
Abstract
Mesenchymal
stem
cells
(MSCs)
are
becoming
hotspots
for
application
in
disease
therapies
recently,
combining
with
biomaterials
and
drug
delivery
system.
A
major
advantage
of
MSCs
applied
system
is
that
these
enable
specific
targeting
releasing
cargos
to
the
sites.
However,
potential
tumor
tropic
effects
raised
concerns
on
biosafety.
To
solve
this
problem,
there
emerging
methods
isolating
cell
membranes
developing
nanoformulations
perform
delivery,
which
avoids
biosafety
without
disturbing
membrane
functions
polarizing
locating.
These
cargoes
so
called
“nanoghosts.”
This
review
article
summarizes
current
applications
nanoghosts,
promising
be
isolation
nanoghost
construction,
possible
approaches
develop
better
harnessing
from
MSC
ghost
membranes.
