Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101616 - 101616
Published: Feb. 26, 2025
Language: Английский
Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6
Published: Oct. 11, 2024
Nanoparticulate delivery systems have been attracting attention in pharmaceutical sciences for enhanced drug bioavailability and targeted delivery. Specifically, these can enhance the solubility of poorly water-soluble drugs, protect therapeutic agents from degradation, prolong circulation time body, control release, facilitate precise targeting drugs to specific tissues or cells. However, once administered into nanoparticles often encounter significant challenges that affect their efficacy safety, such as issues with stability, biocompatibility, targeting. The surface properties are one most important features they greatly influence interactions between themselves biological targets. Key characteristics, charge, hydrophobicity, presence functional groups, determine how behave environments, thereby influencing cellular uptake, ability avoid immune clearance. Modification nanoparticle has shown be an effective approach modulate physicochemical nanoparticles, achieving desired vivo . This review aims summarize recent advances decoration emphasis on improved colloidal reduced toxicity, future perspectives modification approaches also discussed.
Language: Английский
Citations
13
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1059 - 1059
Published: Aug. 12, 2024
Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms enhancing drug effectiveness while mitigating side effects. Despite established success delivery oncology other disciplines, exploration inhaled therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout bronchial tree, offering targeted treatment respiratory diseases. This article conducts a comprehensive review applications medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented insights gleaned trials. Furthermore, examines current future prospects NP-based therapies. By synthesizing data perspectives, underscores transformative promise NP-mediated addressing chronic conditions such as obstructive pulmonary disease, pressing global health concern ranked third mortality rates. overview illuminates evolving landscape inhalation therapies, presenting optimistic avenues advancing medicine improving patient outcomes.
Language: Английский
Citations
11
Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 302, P. 102638 - 102638
Published: March 9, 2022
Language: Английский
Citations
32
Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11
Published: Sept. 28, 2023
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy infectious diseases holds tremendous potential. This innovative approach combines the advantages with protective properties biomaterials, enabling accurate and efficient editing while enhancing safety. Biomaterials play a vital role shielding components, such as lipid nanoparticles or viral vectors, from immunological processes degradation, extending their effectiveness. By utilizing flexibility tailored systems can be designed to address specific genetic diseases, paving way personalized therapeutics. Furthermore, this delivery method offers promising avenues combating illnesses by precisely modifying pathogen genomes, reducing pathogenicity. facilitate site-specific modifications, ensuring effective infected cells minimizing off-target effects. However, challenges remain, including optimizing efficiency, effects, long-term safety, establishing scalable production techniques. Thorough research, pre-clinical investigations, rigorous safety evaluations are imperative successful translation laboratory clinical applications. In review, we discussed how using revolutionizes disease treatment, offering precise safe capabilities potential significantly improve human health quality life.
Language: Английский
Citations
21
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(8)
Published: Nov. 20, 2023
Abstract Most nanomedicines require efficient in vivo delivery to elicit meaningful diagnostic and therapeutic effects. However, en route their intended tissues, systemically administered nanoparticles often encounter barriers. To describe these barriers, the term “nanoparticle blood removal pathways” (NBRP) is proposed, which summarizes interactions between body's various cell‐dependent cell‐independent clearance mechanisms. Nanoparticle design biological modulation strategies are reviewed mitigate nanoparticle‐NBRP interactions. As affect nanoparticle delivery, preclinical literature from 2011–2021 studied, circulation organ biodistribution data analyzed. The findings reveal that surface chemistry affects behavior more than other parameters. Combinatory biological‐PEG modification improves area under curve by ≈418%, with a decrease liver accumulation of up 47%. A greater understanding associated trends will provide new for safer, effective, nanomedicines.
Language: Английский
Citations
19
Small, Journal Year: 2023, Volume and Issue: 20(1)
Published: Aug. 31, 2023
Abstract Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies recently, combining with biomaterials and drug delivery system. A major advantage of MSCs applied system is that these enable specific targeting releasing cargos to the sites. However, potential tumor tropic effects raised concerns on biosafety. To solve this problem, there emerging methods isolating cell membranes developing nanoformulations perform delivery, which avoids biosafety without disturbing membrane functions polarizing locating. These cargoes so called “nanoghosts.” This review article summarizes current applications nanoghosts, promising be isolation nanoghost construction, possible approaches develop better harnessing from MSC ghost membranes.
Language: Английский
Citations
17
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100184 - 100184
Published: June 26, 2024
Polyphenol is a versatile green phytochemical vital in several biomedical applications with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The emergence of novel nanotechnology techniques, such as electrospinning, has proven to be an excellent option for nanotechnology, ensuring effective drug delivery system recognised medicinal plant extracts containing polyphenols electrospun nanofibers can provide the necessary environment encapsulation. Together, have shown promising usage wound healing. When are incorporated into nanofibrous scaffolds, their combined properties enhance cell attachment, proliferation, differentiation. This review explores potential polyphenol-loaded therapy, highlighting importance efficient systems polyphenols. It provides brief assessment specific (resveratrol, curcumin, thymol, quercetin, tannic acid, ferulic hesperidin, gallic kaempferol, chlorogenic acid) that been successfully encapsulated applied treatment. Despite ongoing research, certain carvacrol, oleuropein, kaempferol remain less explored. underscores need continued investigation these while recognising growing application healing more extensive therapeutic use.
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 131027 - 131027
Published: March 20, 2024
Language: Английский
Citations
6
Inflammation, Journal Year: 2022, Volume and Issue: 45(6), P. 2124 - 2141
Published: May 31, 2022
Language: Английский
Citations
23
Science Advances, Journal Year: 2024, Volume and Issue: 10(24)
Published: June 12, 2024
The stemness loss-associated dysregeneration of impaired alveolar type 2 epithelial (AT2) cells abolishes the reversible therapy idiopathic pulmonary fibrosis (IPF). We here report an inhalable mucus-penetrating lipid nanoparticle (LNP) for codelivering dual mRNAs, promoting realveolarization via restoring AT2 IPF treatment. Inhalable LNPs were first formulated with dipalmitoylphosphatidylcholine and our in-house-made ionizable lipids high-efficiency mucus penetration codelivery messenger RNAs (mRNAs), encoding cytochrome b5 reductase 3 bone morphogenetic protein 4, respectively. After being inhaled in a bleomycin model, reverses mitochondrial dysfunction through ameliorating nicotinamide adenine dinucleotide biosynthesis, which inhibits accelerated senescence cells. Concurrently, pathological remodeling fibroblast activation induced by are terminated, ultimately prompting regeneration. Our data demonstrated that mRNA-LNP system exhibited high expression lung cells, markedly extricated collapse prolonged survival mice, providing clinically viable strategy against IPF.
Language: Английский
Citations
5