The Role of the Gut Microbiota in the Relationship Between Diet and Human Health

Annual Review of Physiology, Год журнала: 2022, Номер 85(1), С. 449 - 468

Опубликована: Ноя. 14, 2022

The interplay between diet, the gut microbiome, and host health is complex. Diets associated with have many similarities: high fiber, unsaturated fatty acids, polyphenols while being low in saturated fats, sodium, refined carbohydrates. Over past several decades, dietary patterns changed significantly Westernized nations increased consumption of calorically dense ultraprocessed foods fiber salt, carbohydrates, leading to numerous negative consequences including obesity, metabolic syndrome, cardiovascular disease. microbiota an environmental factor that interacts diet may also impact on outcomes, which involve metabolites produced by from components can host. This review focuses our current understanding complex relationship microbiota, health, examples how support increase individual's risk for disease, be used as a therapy specific diseases.

Язык: Английский

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Celiac disease in children: A review of the literature

World Journal of Clinical Pediatrics, Год журнала: 2021, Номер 10(4), С. 53 - 71

Опубликована: Июль 5, 2021

Celiac disease is an immune-mediated systemic triggered by intake of gluten in genetically susceptible individuals. The prevalence celiac the general population estimated to be 1% world. Its differs depending on geographical and ethnic variations. has increased significantly last 30 years due knowledge awareness physicians widespread use highly sensitive specific diagnostic tests for disease. Despite about disease, up 95% patients still remain undiagnosed. presentations have changed few decades. Classical symptoms occur a minority patients, while older children either minimal or atypical symptoms. Serologic should done with unexplained chronic intermittent diarrhea, failure thrive, weight loss, delayed puberty, short stature, amenorrhea, iron deficiency anemia, nausea, vomiting, abdominal pain, distension, constipation, recurrent aphthous stomatitis, abnormal liver enzyme elevation, who belong groups at risk. Early diagnosis very important prevent long-term complications. Currently, only effective treatment lifelong gluten-free diet. In this review, we will discuss epidemiology, clinical findings, tests, light latest literature.

Язык: Английский

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Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

Nutrients, Год журнала: 2020, Номер 12(6), С. 1832 - 1832

Опубликована: Июнь 19, 2020

Celiac disease (CD) and non-celiac gluten/wheat sensitivity (NCG/WS) are the two most frequent conditions belonging to gluten-related disorders (GRDs). Both these diseases triggered worsened by gluten proteins ingestion, although other components, such as amylase/trypsin inhibitors (ATI) fermentable oligosaccharides, disaccharides, monosaccharides polyols (FODMAPs), seem be involved in NCG/WS onset. Therefore, only effective treatment date is long-life adherence a strictly gluten-free diet. Recently, increasing attention has been paid intestinal barrier, dynamic system comprising various which regulate delicate crosstalk between metabolic, motor, neuroendocrine immunological functions. Among elements characterizing microbiota plays key role, modulating gut integrity maintenance, immune response inflammation process, linked CD outbreak. This narrative review addresses recent findings on modulation induced diet (GFD) healthy, patients.

Язык: Английский

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The Gluten-Free Diet for Celiac Disease and Beyond

Nutrients, Год журнала: 2021, Номер 13(11), С. 3993 - 3993

Опубликована: Ноя. 9, 2021

The gluten-free diet (GFD) has gained popularity beyond its main medical indication as the treatment for gluten-induced immune-mediated disorders such celiac disease (CD), dermatitis herpetiformis, gluten ataxia, wheat allergy, and non-celiac sensitivity. However, carries some disadvantages elevated costs, nutritional deficiencies, social psychological barriers. present work aims to review indications, proven benefits, adverse events of a diet. Close follow-up with patients following is recommended. More data needed assess effectiveness in managing mental cognitive establish connection between brain gluten.

Язык: Английский

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Postbiotics as the new frontier in food and pharmaceutical research

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(26), С. 8375 - 8402

Опубликована: Март 29, 2022

Food is the essential need of human life and has nutrients that support growth health. Gastrointestinal tract microbiota involves valuable microorganisms develop therapeutic effects are characterized as probiotics. The investigations on appropriate probiotic strains have led to characterization specific metabolic byproducts probiotics named postbiotics. must maintain their survival against inappropriate lethal conditions processing, storage, distribution, preparation, digestion system so they can exhibit most health effects. Conversely, metabolites (postbiotics) successfully overcome these unfavorable may be an alternative Due chemical structure, safe profile, long shelf-life, fact contain various signaling molecules, postbiotics anti-inflammatory, immunomodulatory, antihypertensive properties, inhibiting abnormal cell proliferation antioxidative activities. Consequently, present scientific literature approves mimic fundamental clinical role probiotics, due unique characteristics, applied in oral delivery (pharmaceutical/functional foods), a preharvest food safety hurdle, promote shelf-life products novel functional foods or/and for developing benefits, aims. This review addresses latest postbiotic applications with regard pharmaceutical formulations commercial food-based products. Potential promotion host status, prevention disease, complementary treatment also reviewed.

Язык: Английский

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The global burden of coeliac disease: opportunities and challenges

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 19(5), С. 313 - 327

Опубликована: Янв. 3, 2022

Язык: Английский

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Fermented foods and gastrointestinal health: underlying mechanisms

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 21(4), С. 248 - 266

Опубликована: Дек. 11, 2023

Язык: Английский

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Global nutritional challenges and opportunities: Buckwheat, a potential bridge between nutrient deficiency and food security

Trends in Food Science & Technology, Год журнала: 2024, Номер 145, С. 104365 - 104365

Опубликована: Фев. 5, 2024

Язык: Английский

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Gluten-Free Diet and Other Celiac Disease Therapies: Current Understanding and Emerging Strategies

Nutrients, Год журнала: 2024, Номер 16(7), С. 1006 - 1006

Опубликована: Март 29, 2024

A lifelong gluten-free diet (GFD) is the only treatment for celiac disease and other gluten-related disorders. Nevertheless, strict adherence to GFD often challenging due concerns about social isolation, risk of gluten contaminations, high cost, poor quality taste products. Moreover, although effective in achieving mucosal healing, it may lead dietary imbalances nutrient deficiencies over a long period time. To overcome these issues, several wheat flours have been developed create products that closely resemble their gluten-containing counterparts. Furthermore, given critical importance adhering GFD, becomes essential promote monitor possible voluntary or involuntary transgressions. Various methods, including clinical assessment, questionnaires, serology disease, duodenal biopsies detection Gluten Immunogenic Peptides (GIPs) are employed this purpose, but none considered entirely satisfactory. Since poses challenges, alternative therapies should be implemented coming years improve efficacy life patients with disease. The aim narrative review explore current knowledge investigate its future perspectives, focusing on technology advancements, follow-up strategies insights into rapidly changing future.

Язык: Английский

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Celiac Disease: A Transitional Point of View

Nutrients, Год журнала: 2025, Номер 17(2), С. 234 - 234

Опубликована: Янв. 10, 2025

Celiac disease (CeD) is a chronic, lifelong, multifactorial, polygenic, and autoimmune disorder, characteristically triggered by exposure to the exogenous factor "gluten" in genetically predisposed individuals, with resulting duodenal inflammation enteropathy, as well heterogeneous multisystemic extraintestinal manifestations. The immunopathogenesis of CeD complex, favored peculiar human leukocyte antigen (HLA) genetic predisposition, leading gluten presentation antigen-presenting cells CD4+ T helper (Th) cells, cell-B cell interactions, production specific antibodies, immune-mediated killing enterocytes and, macroscopically, inflammation. Here, most relevant correlations between cellular molecular aspects clinical manifestations this complex are reviewed, final considerations on nutritional for management.

Язык: Английский

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