Polymers,
Год журнала:
2022,
Номер
14(15), С. 3023 - 3023
Опубликована: Июль 26, 2022
Nowadays,
there
are
still
numerous
challenges
for
well-known
biomedical
applications,
such
as
tissue
engineering
(TE),
wound
healing
and
controlled
drug
delivery,
which
must
be
faced
solved.
Hydrogels
have
been
proposed
excellent
candidates
these
they
promising
properties
the
mentioned
including
biocompatibility,
biodegradability,
great
absorption
capacity
tunable
mechanical
properties.
However,
depending
on
material
or
manufacturing
method,
resulting
hydrogel
may
not
up
to
specific
task
it
is
designed,
thus
different
approaches
enhance
performance
requirements
of
application
in
question.
The
main
purpose
this
review
article
was
summarize
most
recent
trends
technology,
going
through
used
polymeric
materials
popular
synthesis
methods
years,
strategies
enhancing
hydrogels'
properties,
cross-linking
manufacture
composite
hydrogels.
In
addition,
secondary
objective
briefly
discuss
other
novel
applications
hydrogels
that
past
few
years
drawn
a
lot
attention.
Military Medical Research,
Год журнала:
2022,
Номер
9(1)
Опубликована: Ноя. 19, 2022
Abstract
Bone,
cartilage,
and
soft
tissue
regeneration
is
a
complex
spatiotemporal
process
recruiting
variety
of
cell
types,
whose
activity
interplay
must
be
precisely
mediated
for
effective
healing
post-injury.
Although
extensive
strides
have
been
made
in
the
understanding
immune
microenvironment
processes
governing
bone,
regeneration,
clinical
translation
these
mechanisms
remains
challenge.
Regulation
increasingly
becoming
favorable
target
regeneration;
therefore,
an
in-depth
communication
between
cells
functional
would
valuable.
Herein,
we
review
regulatory
role
promotion
maintenance
stem
states
context
repair
regeneration.
We
discuss
roles
various
subsets
introduce
novel
strategies,
example,
biomaterial-targeting
activity,
aimed
at
regulating
healing.
Understanding
crosstalk
pathways
may
shed
light
on
new
therapeutic
opportunities
enhancing
through
regulation
microenvironment.
Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Сен. 19, 2023
Abstract
Nanozymes,
as
one
of
the
most
efficient
reactive
oxygen
species
(ROS)‐scavenging
biomaterials,
are
receiving
wide
attention
in
promoting
diabetic
wound
healing.
Despite
recent
attempts
at
improving
catalytic
efficiency
Pt‐based
nanozymes
(e.g.,
PtCu,
best
systems),
they
still
display
quite
limited
ROS
scavenging
capacity
and
ROS‐dependent
antibacterial
effects
on
bacteria
or
immunocytes,
which
leads
to
uncontrolled
poor
Hence,
a
new
class
multifunctional
PtCuTe
nanosheets
with
excellent
catalytic,
ROS‐independent
antibacterial,
proangiogenic,
anti‐inflammatory,
immuno‐modulatory
properties
for
boosting
healing,
is
reported.
The
show
stronger
better
than
PtCu.
It
also
revealed
that
can
enhance
vascular
tube
formation,
stimulate
macrophage
polarization
toward
M2
phenotype
improve
fibroblast
mobility,
outperforming
conventional
Moreover,
promotes
crosstalk
between
different
cell
types
form
positive
feedback
loop.
Consequently,
stimulates
proregenerative
environment
relevant
populations
ensure
normal
tissue
repair.
Utilizing
mouse
model,
it
demonstrated
significantly
facilitated
regeneration
highly
vascularized
skin,
percentage
closure
being
over
90%
8th
day,
among
reported
comparable
biomaterials.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(10)
Опубликована: Янв. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
488, С. 150631 - 150631
Опубликована: Март 26, 2024
The
skeletal
system
is
essential
for
preserving
body
structure
and
facilitating
mobility;
however,
bone
diseases
frequently
result
in
significant
disabilities,
necessitating
the
investigation
into
biomaterials
restoration.
Nevertheless,
these
may
elicit
immune
reactions
that
obstruct
healing
process.
Macrophages
assume
a
pivotal
role
modulating
inflammation
sustaining
homeostasis
regeneration.
A
comprehensive
understanding
of
molecular
interactions
between
macrophages
imperative
development
sophisticated
designed
to
regulate
environment
promote
remodeling.
This
review
delves
generation,
polarization,
interaction
with
principal
cell
types
implicated
osteogenesis,
detailing
mechanisms
by
which
influence
repair
their
response
biomaterials.
Additionally,
it
discusses
strategies
precise
modulation
macrophage
functionality
via
intelligent
mechanisms,
outlines
challenges
constraints
designing
integrate
functions.
By
elucidating
challenges,
lays
groundwork
creation
advanced
endowed
smart
immunomodulatory
capabilities,
heralding
novel
approaches
treatment
defects
advancement
regeneration
therapies.
Abstract
Diabetes
mellitus,
a
pervasive
chronic
metabolic
disorder,
is
often
associated
with
complications
such
as
impaired
wound
healing.
Various
factors,
most
notably
vascular
deficiency,
govern
the
repair
process
in
diabetic
patients,
significantly
impeding
healing;
therefore,
angiogenesis
and
its
role
have
emerged
important
areas
of
research.
This
review
aims
to
delve
into
mechanisms
angiogenesis,
effects
diabetes
on
association
between
repair.
will
ultimately
offer
valuable
guidance
regarding
ideal
timing
treatment
clinical
setting.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Abstract
Successful
wound
healing
is
a
process
that
has
three
overlying
phases:
inflammatory,
proliferative
and
remodeling.
Chronic
wounds
are
characterized
by
perpetuated
inflammation
inhibits
the
remodeling
phases
impairs
healing.
Macrophages
key
modulators
of
process.
Initially,
they
responsible
for
cleaning
phagocytosis
pathogens
afterwards
lead
to
resolution
inflammatory
response
express
growth
factors
important
angiogenesis
cytokines
needed
cell
proliferation
deposition
extracellular
matrix.
The
phenotype
macrophage
changes
gradually
throughout
from
initial
M1
pro-inflammatory
characteristic
acute
M2
pro-regenerative
allows
an
accurate
tissue
repair.
In
chronic
wounds,
macrophages
persist
impair
As
such,
immunomodulatory
biomaterials
arise
as
promising
solutions
accelerate
this
review,
we
discuss
importance
their
polarization
different
healing;
dysfunction
in
use
overcome
critical
problem
wounds—the
continued
phase
