Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)

Опубликована: Июль 1, 2022

Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.

Язык: Английский

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Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy

Pharmacological Research, Год журнала: 2022, Номер 184, С. 106418 - 106418

Опубликована: Авг. 28, 2022

Язык: Английский

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(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(1)

Опубликована: Июнь 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Язык: Английский

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Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204

Опубликована: Янв. 4, 2023

Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective

Язык: Английский

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A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk

Pharmacological Research, Год журнала: 2023, Номер 194, С. 106822 - 106822

Опубликована: Июнь 17, 2023

Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year survival rate less than 10%, even in developed countries such as USA. The genomic profile alterations and dysregulated biological mechanisms commonly occur PC. Macroautophagy/autophagy cell death process that maintained at basal level physiological conditions, whereas its often changes during tumorigenesis. function of autophagy human cancers dual can be oncogenic onco-suppressor. Autophagy potent controller tumorigenesis supportive PC escalates growth cells suppression mediate death. also determines metastasis cells, it control EMT affecting migration. Moreover, starvation hypoxia stimulate glycolysis, glycolysis induction mediated by enhancing Furthermore, protective stimulates drug resistance gemcitabine inhibition enhance radiosensitivity. degrade MHC-I to immune evasion regulates polarization macrophages tumor microenvironment. Modulation activity provided silibinin, ursolic acid, chrysin huaier treatment Non-coding RNAs are controllers improve therapy response patients. mitophagy shows dysregulation PC, proliferation cells. Therefore, bioinformatics analysis demonstrates autophagy-related proteins genes biomarkers.

Язык: Английский

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microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3521 - 3521

Опубликована: Фев. 9, 2023

Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary brain tumor. GBM characterized by an infiltrating growth nature, abundant vascularization, and a rapid aggressive clinical course. For many years, standard treatment of gliomas has invariably been surgical supported radio- chemotherapy. Due to location significant resistance conventional therapies, prognosis glioblastoma patients very poor cure rate low. The search for new therapy targets effective therapeutic tools cancer current challenge medicine science. microRNAs (miRNAs) play key role in cellular processes, such as growth, differentiation, cell division, apoptosis, signaling. Their discovery was breakthrough diagnosis diseases. Understanding structure miRNAs may contribute understanding mechanisms regulation dependent on miRNA pathogenesis diseases underlying these short non-coding RNAs, including glial tumors. This paper provides detailed review latest reports relationship between changes expression individual formation development gliomas. use this also discussed.

Язык: Английский

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Paclitaxel and docetaxel resistance in prostate cancer: Molecular mechanisms and possible therapeutic strategies

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114392 - 114392

Опубликована: Фев. 15, 2023

Prostate cancer is among most malignant tumors around the world and this urological tumor can be developed as result of genomic mutations their accumulation during progression towards advanced stage. Due to lack specific symptoms in early stages prostate cancer, patients are diagnosed that cells display low response chemotherapy. Furthermore, enhance aggressiveness cells. Docetaxel paclitaxel suggested well-known compounds for chemotherapy they possess a similar function therapy based on inhibiting depolymerization microtubules, impairing balance microtubules subsequent delay cell cycle progression. The aim current review highlight mechanisms docetaxel resistance cancer. When oncogenic factors such CD133 upregulation PTEN tumor-suppressor shows decrease expression, malignancy enhances induce drug resistance. phytochemicals anti-tumor have been utilized suppressing chemoresistance Naringenin lovastatin used enhancing sensitivity. Moreover, nanostructures polymeric micelles nanobubbles delivery decreasing risk development. These subjects highlighted provide new insight reversing

Язык: Английский

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Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132579 - 132579

Опубликована: Май 23, 2024

Язык: Английский

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Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis

Journal of Cancer, Год журнала: 2024, Номер 15(7), С. 1916 - 1928

Опубликована: Янв. 1, 2024

Background: Accumulating evidence indicates that non-coding RNAs (ncRNA), including long (lncRNAs) and circular (circRNAs), can function as competitive endogenous (ceRNAs) by binding to microRNAs (miRNAs) regulating host gene expression at the transcriptional or post-transcriptional level.Dysregulation in ceRNA network regulation has been implicated occurrence development of cancer.However, lncRNA/circRNA-miRNA-mRNA regulatory is still lacking nasopharyngeal carcinoma (NPC).Methods: Differentially expressed genes (DEGs) were obtained from our previous sequencing data Gene Expression Omnibus (GEO).Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes pathway (KEGG) used explore biological functions these common DEGs.Through a series bioinformatic analyses, was established.In additional, external GSE102349 test prognostic value hub mRNAs through Kaplan-Meier method.Results: We successfully constructed NPC, consisting 16 lncRNAs, 6 miRNAs, 3 circRNAs 10 found three (TOP2A, ZWINT, TTK) significantly associated with overall survival time (OS) patients. Conclusion:The revealed this study may help comprehensively elucidate mechanisms driving provide novel candidate biomarkers for evaluating prognosis NPC.

Язык: Английский

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Complex roles of autophagy in cancer development, immune evasion, and drug resistance

Drug Resistance Updates, Год журнала: 2024, Номер 78, С. 101170 - 101170

Опубликована: Ноя. 15, 2024

Язык: Английский

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